Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise

Luo, Lan; Li, Rui; Wang, Guiping; Chen, Jingsi; Chen, Liangkai; Qin, Li–Qiang; Yu, Zengli; Wan, Zhongxiao

doi:10.1039/d1fo03241k

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…Allobaculum , which is involved in butyric acid production [ 48 , 49 ], increases following the consumption of a high fat diet in rodents that produces cognitive impairments [ 38 , 50 , 51 ]. While this suggest that increased levels of Allobaculum may be related to suboptimal health, other studies have reported that voluntary exercise can lead to enhanced abundance of Allobaculum [ 52 , 53 ]. Thus, future studies should attempt to manipulate Allobaculum abundance directly to examine the impact on cognitive function and metabolic health.…”

Section: Discussionmentioning

confidence: 98%

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

et al. 2022

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Declining health, gut dysbiosis, and cognitive impairments are hallmarks of advanced age. While caloric restriction is known to robustly extend the healthspan and alter gut microbiome composition, it is difficult maintain. Time-restricted feeding or changes in dietary macronutrient composition could be feasible alternatives for enhancing late life cognitive and physical health that are easier to comply with for extended periods of time. To investigate this possibility, 8-month-old rats were placed on time-restricted feeding with a ketogenic or micronutrient- and calorically matched control diet for 13 months. A third group of rats was permitted to eat standard chow ad libitum during this time. At 22 months, all rats were tested on a biconditional association task and fecal samples were collected for microbiome composition analysis. Regardless of dietary composition, time-restricted-fed rats had better cognitive performance than ad libitum-fed rats. This observation could not be accounted for by differences in motivation, procedural or sensorimotor impairments. Additionally, there were significant differences in gut microbiome diversity and composition between all diet conditions. Allobaculum abundance was associated with cognitive task performance, indicating a link between gut health and cognitive outcomes in aged subjects. Overall, time restricted feeding had the largest influence on cognitive performance in aged rats.

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Section: Discussionmentioning

confidence: 98%

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

et al. 2022

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“…Our results show that several of these SCFA-producing families allow performance prediction according to the GEE models, such as Coriobacteriaceae and Bifidobacteriaceae , from PC1, Erysipelotrichaceae from PC2, and Sutterellaceae from PC3. These families have previously been described as associated with improved physical performance and exercise-related health status in mouse and human studies [ 27 , 28 ]. Thus, Coriobacteriaceae abundance has been described as a biomarker linking physical exercise with improved health status, probably via diverse catabolic pathways, such as secondary bile acids and aldosterone 18-glucuronide metabolism, involved in sodium homeostasis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Dynamics of Gut Microbiota and Short-Chain Fatty Acids during a Cycling Grand Tour Are Related to Exercise Performance and Modulated by Dietary Intake

Fernandez-Sanjurjo,

Fernandez,

Martinez-Camblor

et al. 2024

Nutrients

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Background: Regular exercise has been described to modify both the diversity and the relative abundance of certain bacterial taxa. To our knowledge, the effect of a cycling stage race, which entails extreme physiological and metabolic demands, on the gut microbiota composition and its metabolic activity has not been analysed. Objective: The aim of this cohort study was to analyse the dynamics of faecal microbiota composition and short-chain fatty acids (SCFAs) content of professional cyclists over a Grand Tour and their relationship with performance and dietary intake. Methods: 16 professional cyclists competing in La Vuelta 2019 were recruited. Faecal samples were collected at four time points: the day before the first stage (A); after 9 stages (B); after 15 stages (C); and on the last stage (D). Faecal microbiota populations and SCFA content were analysed using 16S rRNA sequencing and gas chromatography, respectively. A principal component analysis (PCA) followed by Generalised Estimating Equation (GEE) models were carried out to explore the dynamics of microbiota and SCFAs and their relationship with performance. Results: Bifidobacteriaceae, Coriobacteriaceae, Erysipelotrichaceae, and Sutterellaceae dynamics showed a strong final performance predictive value (r = 0.83, ranking, and r = 0.81, accumulated time). Positive correlations were observed between Coriobacteriaceae with acetate (r = 0.530) and isovalerate (r = 0.664) and between Bifidobacteriaceae with isobutyrate (r = 0.682). No relationship was observed between SCFAs and performance. The abundance of Erysipelotrichaceae at the beginning of La Vuelta was directly related to the previous intake of complex-carbohydrate-rich foods (r = 0.956), while during the competition, the abundance of Bifidobacteriaceae was negatively affected by the intake of simple carbohydrates from supplements (r = −0.650). Conclusions: An ecological perspective represents more realistically the relationship between gut microbiota composition and performance compared to single-taxon approaches. The composition and periodisation of diet and supplementation during a Grand Tour, particularly carbohydrates, could be designed to modulate gut microbiota composition to allow better performance.

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“…At present, most studies used heat‐treated foods for feeding mice to study the effects of dietary AGEs intake on organismal health (Luo, Li, et al, 2022; Roncero‐Ramos et al, 2013). However, extensive heat processing foods contain various antinutritional and toxic compounds derived from the Maillard reaction (e.g., acrylamide [Quan et al, 2022], heterocyclic aromatic amines [Dong et al, 2020], and 5‐hydroxymethylfurfural [Han et al, 2019; Pérez‐Burillo et al, 2019]).…”

Section: Introductionmentioning

confidence: 99%

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

Wen

Zhang

Xia

et al. 2023

eFood

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This study evaluated the biological effects of exogenous advanced glycation end products (AGEs) on the induction of chronic kidney disease and the dose‐effect relationship. Male C57BL/6 mice were placed on four diets, including saline and three other diets differing only in AGEs content (low‐AGEs [LA], medium‐AGEs [MA], and high‐AGEs [HA] ratio, 1:3:5) for 4 weeks. With the increasing intake of AGEs, mice developed a significant increase in blood glucose and lipid levels, the fluorescence intensity of AGEs, Nε‐(carboxymethyl)‐lysine, Nε‐(carboxyethyl)‐lysine, and malondialdehyde levels, whereas their superoxide dismutase activity and glutathione levels were decreased significantly. HA had the highest urinary protein levels and the lowest creatinine clearance compared to the other groups. These suggested that AGEs are an essential contributor to increasing oxidative stress levels and intake of high‐level AGEs induces more severe kidney function impairment. Meanwhile, the AGEs intake damaged the kidney structure in a dose‐dependent manner, as evidenced by granular degeneration of kidney tubular epithelial cells and inflammatory cell infiltration. These findings shed light on the detrimental impacts of AGEs on human kidneys, which also will help reveal a dose‐effect relationship of AGEs.

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Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise

Abstract: To determine whether high fat diet (HFD) combined with advanced glycation end products (AGEs) diet will induce worse cognitive impairment than HFD per se, and whether voluntary exercise is capable...

Cited by 7 publications

References 48 publications

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

Dynamics of Gut Microbiota and Short-Chain Fatty Acids during a Cycling Grand Tour Are Related to Exercise Performance and Modulated by Dietary Intake

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

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