Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

Chen, Chiao Nan; Liao, Yi Hung; Tsai, Shau‐Wei; Thompson, La Dora V.

doi:10.1007/s11357-019-00109-8

Cited by 35 publications

(37 citation statements)

References 56 publications

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“…CR inhibited mTORC1 expression in the liver of BMAL1- or CRY-deficient mice but enhanced mTORC2 capability only in the liver of CRY-deficient mice [ 186 ]. CR also protected the skeletal muscle mass in middle-aged rats by regulating mTOR signaling and the ubiquitin-proteasome pathway [ 187 ]. Ten months of CR protected against neuronal loss caused by aging and injury and improved learning and memory via the mTOR pathway [ 188 ].…”

Section: Mtor Signalingmentioning

confidence: 99%

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Zhang

Wang

et al. 2021

Cells

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Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.

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Section: Mtor Signalingmentioning

confidence: 99%

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Zhang

Wang

et al. 2021

Cells

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“…However, iron metabolism is not the only player affecting muscle performance. Due to the complexity of muscle physiology, other factors can have a decisive influence on skeletal muscle, such as age, lipotoxicity, muscle stiffness, and the role of caloric restriction in muscle health [ 54 , 55 , 56 ]. In this way, sarcopenia is the age-associated loss of muscle mass and function.…”

Section: Potential Application and Future Prospects Of Black Peppementioning

confidence: 99%

“…Moreover, histopathological muscle changes as a result of the pathways triggered by sarcopenia, which affect muscle performance, are changes in muscle fiber size and number, causing mass muscle reduction with age and selective atrophy of muscle fibers [ 54 , 56 ]. In addition, another factor to consider in performance and muscle function is caloric restriction (CR) [ 55 ]. CR-induced effects are related to aging in skeletal muscle.…”

Section: Potential Application and Future Prospects Of Black Peppementioning

confidence: 99%

“…CR-induced effects are related to aging in skeletal muscle. In an animal model, Chen et al [ 55 ] observed that CR modulates mTOR signaling and the ubiquitin-proteasome pathway (UPP). CR did not alter mTOR signaling and UPP in the soleus muscles of young and adult rats, whereas CR altered the pathways in middle-aged rats, stimulating muscle protein degradation [ 55 ].…”

Section: Potential Application and Future Prospects Of Black Peppementioning

confidence: 99%

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Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications

et al. 2020

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Black pepper (Piper nigrum L.) has been employed in medicine (epilepsy, headaches, and diabetes), where its effects are mainly attributed to a nitrogen alkaloid called piperidine (1-(1-[1,3-benzodioxol-5-yl]-1-oxo-2,4 pentenyl) piperidine). Piperine co-administered with vitamins and minerals has improved its absorption. Therefore, this study aimed to describe the impact of the joint administration of iron (Fe) plus black pepper in physically active healthy individuals. Fe is a micronutrient that aids athletic performance by influencing the physiological functions involved in endurance sports by improving the transport, storage, and utilization of oxygen. Consequently, athletes have risk factors for Fe depletion, Fe deficiency, and eventually, anemia, mainly from mechanical hemolysis, gastrointestinal disturbances, and loss of Fe through excessive sweating. Declines in Fe stores have been reported to negatively alter physical capacities such as aerobic capacity, strength, and skeletal muscle recovery in elite athletes. Thus, there is a need to maintain Fe storage, even if Fe intake meets the recommended daily allowance (RDA), and Fe supplementation may be justified in physically active individuals, in states of Fe deficiency, with or without anemia. Females, in particular, should monitor their Fe hematological profile. The recommended oral Fe supplements are ferrous or ferric salts, sulfate, fumarate, and gluconate. These preparations constitute the first line of treatment; however, the high doses administered have gastrointestinal side effects that reduce tolerance and adherence to treatment. Thus, a strategy to counteract these adverse effects is to improve the bioavailability of Fe. Therefore, piperine may benefit the absorption of Fe through its bioavailability enhancement properties. Three research studies of Fe associated with black pepper have reported improvements in parameters related to the metabolism of Fe, without adverse effects. Although more research is needed, this could represent an advance in oral Fe supplementation for physically active individuals.

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“…As a family of stress-induced proteins, Sestrins are involved in the maintenance of cellular homeostasis, as well as in tumorigenesis by regulating various downstream molecules of mTOR signaling pathway ( Wang et al, 2019 ). Emerging studies have shown that mTOR-associated pathways are closely related to cell growth and metabolism in different human disorders, including cancers ( Chen et al, 2019 ; Chung et al, 2019 ; Garcia et al, 2019 ). l -Leucine is an amino acid that plays an important role in the protein synthesis ( Vago et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling

Guo¹,

Zhu²,

Wang³

et al. 2020

Front. Pharmacol.

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The mTOR signaling pathway is abnormally activated in pancreatic cancer and is related to tumor glucose metabolism. However, its specific regulation mechanism is still unclear. Therefore, this study aims to investigate whether Sestrin2 affects the glucose metabolism of pancreatic cancer by modulating mTOR signal and then affects its biological behavior. We have observed that l-leucine can promote the proliferation of pancreatic cancer cells and increase the expression of Sestrin2 and p-mTOR proteins. In order to further study the role of Sestrin2 and mTOR signaling in pancreatic cancer, we conducted Sestrin2 overexpression and mTOR pharmacological inhibition experiments. We found that Sestrin2 overexpression can increase glycolysis of pancreatic cancer cells and promote their proliferation. This effect can be eliminated by mTOR inhibitors. Finally, we found that Sestrin2 knockdown could inhibit the growth of pancreatic cancer in vivo. In conclusion, these findings suggest that Sestrin2 may promote the occurrence and development of pancreatic cancer through mTOR signaling.

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Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

Cited by 35 publications

References 56 publications

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Iron and Physical Activity: Bioavailability Enhancers, Properties of Black Pepper (Bioperine®) and Potential Applications

CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling

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