“…To fight COVID-19, neither vaccines nor therapeutic treatments are currently available. Understanding the pathogenesis of the SARS-CoV-2 infection is key to maximize prevention and to develop therapeutic solutions, and this is possible through susceptible animal models such as non-human primates (cynomolgus (Macacca fascicularis) and rhesus (Macacca mulatta) macaques), cats, hamsters and ferrets (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)], being the two latest species the most economic and easiest to house and handle. To our knowledge, all ferrets and hamsters experimental infection studies (9,13),] published so far, apart from two studies (9,13),] were performed with high doses of SARS-CoV-2 (ranging from 8.10 4 TCID50 to 10 5.5 TCID50 or 10 6 pfu per animal), independently of animal weight and mainly with the objective of inducing severe infections.…”