Age‐dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double‐positive CD4+ CD8+ cells and B220+ T cells, in mice

Ishimoto, Yuiko; Tomiyama-Miyaji, Chikako; Watanabe, Hirotaka; Yokoyama, Hisashi; Ebe, Kazuto; Tsubata, Shunsuke; Aoyagi, Yoshinobu; Abo, Toru

doi:10.1111/j.1365-2567.2004.01961.x

Cited by 54 publications

(39 citation statements)

References 25 publications

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“…However, since the COPD patients were older than the control subjects (smokers or nonsmokers), it is unlikely that this difference might have influenced the proximal airway inflammation despite some data obtained in rodents showing an increase in CD45R0 cells with ageing [32]. The contribution of proximal airways to COPD was associated with the chronic bronchitis phenotype.…”

Section: Discussionmentioning

confidence: 97%

Does leptin play a cytokine-like role within the airways of COPD patients?

Bruno¹,

Chanez²,

Chiappara³

et al. 2005

Eur Respir J

100

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The leptin-leptin receptor system might be up-regulated in the airways of chronic obstructive pulmonary disease (COPD). In bronchial biopsies obtained from normal subjects and smokers, with and without COPD, the present study examined leptin and leptin-receptor expression and their co-localisation in airway and inflammatory cells.Combining immunohistochemistry with terminal deoxynucleotidyl transferase dUTP nick endlabelling techniques, apoptosis in airway and inflammatory cells and in leptin and leptin-receptor expressing cells was investigated. In the epithelial cells both leptin and leptin-receptor expression was higher in normal subjects than in smokers and COPD subjects. By contrast, in the submucosa, leptin was over-expressed in COPD when compared with normal subjects and smokers. Leptin and its receptor were co-localised, mainly with activated T cells (CD45R0) and CD8 + T lymphocytes. In smokers, apoptosis was found in some inflammatory cells, whereas in COPD inflammatory cells, leptin and leptin-receptor positive cells were not apoptotic. Leptin expression was related to COPD severity and assessed using the Global initiative for Chronic Obstructive Lung Disease classification.In conclusion, the present study shows an increased leptin expression in bronchial mucosa of chronic obstructive pulmonary disease patients, associated with airway inflammation and airflow obstruction.

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Section: Discussionmentioning

confidence: 97%

Does leptin play a cytokine-like role within the airways of COPD patients?

Bruno¹,

Chanez²,

Chiappara³

et al. 2005

Eur Respir J

100

View full text Add to dashboard Cite

show abstract

“…suspicion that NKT cells play a role in the risk to develop of UC ( 45 ). It should be pointed out, however, that a recent clinical trial in which IL-13 was blocked in patients with UC has been convincingly negative ( 46 ).…”

Section: The Red Sectionmentioning

confidence: 97%

The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms

Sahami

Kooij

Meijer

et al. 2016

American Journal of Gastroenterology

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The human appendix has long been considered as a vestigial organ, an organ that has lost its function during evolution. In recent years, however, reports have emerged that link the appendix to numerous immunological functions in humans. Evidence has been presented for an important role of the appendix in maintaining intestinal health. This theory suggests that the appendix may be a reservoir or 'safe house' from which the commensal gut flora can rapidly be reestablished if it is eradicated from the colon. However, the appendix may also have a role in the development of inflammatory bowel disease (IBD). Several large epidemiological cohort studies have demonstrated the preventive effect of appendectomy on the development of ulcerative colitis, a finding that has been confirmed in murine colitis models. In addition, current studies are examining the possible therapeutic effect of an appendectomy to modulate disease course in patients with ulcerative colitis. This literature review assesses the current knowledge about the clinical and immunological aspects of the vermiform appendix in IBD and suggests that the idea of the appendix as a vestigial remnant should be discarded.

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“…Few studies of NKT cells in the elderly have been carried out and their numbers may increase during ageing (Dubey et al, 2000;Faunce et al, 2005;Ishimoto et al, 2004). This may be attributed to a longer life span (Berzins et al, 2006) rather than an increased proliferative capacity (DelaRosa et al, 2002;Peralbo et al, 2007;Peralbo et al, 2006).…”

Section: Nk Cells In Ageingmentioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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Age‐dependent variation in the proportion and number of intestinal lymphocyte subsets, especially natural killer T cells, double‐positive CD4⁺ CD8⁺ cells and B220⁺ T cells, in mice

Cited by 54 publications

References 25 publications

Does leptin play a cytokine-like role within the airways of COPD patients?

Does leptin play a cytokine-like role within the airways of COPD patients?

The Link between the Appendix and Ulcerative Colitis: Clinical Relevance and Potential Immunological Mechanisms

Nutrition, diet and immunosenescence

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