Age differences in cholinergic airway responsiveness in relation with muscarinic receptor subtypes

Lee, Hye Kyung; Lim, Mi Young; Bok, Se-Mi; Cho, Eui-Sic; Lee, Eun Mi; Kim, Seung Whan; Kim, Young-Hoon; Kim, Hae Won

doi:10.1016/j.lfs.2007.05.002

Cited by 7 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there is little research on whether the expression of muscarinic receptors changes with age in asthma. Lee et al33 observed that airway smooth muscle is more sensitive to acetylcholine in vivo and in vitro in young rats than in older rats, possibly because of greater expression of M2 and M3 muscarinic receptors in smooth muscle in young rats. By contrast, the present study showed an increased expression of M3 subtype and a decreased expression of M2 subtype in the lung tissue from older OVA mice compared with young OVA mice, although only M3 expression in the 9-month-old OVA group had a statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model

Kang¹,

Lee²,

Rhee³

et al. 2013

CIA

View full text Add to dashboard Cite

Background and objectivesThe influence of aging on the development of asthma has not been studied thoroughly. The aim of this study was to investigate age-related airway responses involving lung histology and expression of muscarinic receptors in a murine model of acute asthma.MethodsFemale BALB/c mice at the ages of 6 weeks and 6, 9, and 12 months were sensitized and challenged with ovalbumin (OVA) for 1 month (n = 8–12 per group). We analyzed inflammatory cells and T-helper (Th)2 cytokines in bronchoalveolar lavage (BAL) fluid and parameters of airway remodeling and expression of muscarinic receptors in lung tissue.ResultsAmong the OVA groups, total cell and eosinophil numbers in BAL fluid were significantly higher in the older (6-, 9-, and 12-month-old) mice than in the young (6-week-old) mice. Interleukin (IL) 4 (IL-4) concentration increased, but IL-5 and IL-13 concentrations showed a decreased tendency, with age. IL-17 concentration tended to increase with age, which did not reach statistical significance. Periodic acid-Schiff (PAS) staining area, peribronchial collagen deposition, and area of α-smooth muscle staining were significantly higher in the 6-month older OVA group than in the young OVA group. The expression of the M3 and M2 muscarinic receptors tended to increase and decrease, respectively, with age.ConclusionThe aged mice showed an active and unique pattern not only on airway inflammation, but also on airway remodeling and expression of the muscarinic receptors during the development of acute asthma compared with the young mice. These findings suggest that the aging process affects the pathogenesis of acute asthma and age-specific approach might be more appropriate for better asthma control in a clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model

Kang¹,

Lee²,

Rhee³

et al. 2013

CIA

View full text Add to dashboard Cite

show abstract

“…Finally, airway hyperreactivity has been universally found to be greater in young versus aged animals. [226][227][228][229]231 The mechanisms might be complex, including both an altered key cytokine milieu and alterations in muscle function at the muscarinic receptor level. [231][232][233]…”

Section: Areas Of Research Experimental Approachesmentioning

confidence: 99%

Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop

Hanania

King

Braman

et al. 2011

Journal of Allergy and Clinical Immunology

215

198

View full text Add to dashboard Cite

Asthma in the elderly (AIE) is under diagnosed and under treated and there is a paucity of knowledge. The National Institute on Aging convened this workshop to identify what is known, what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of AIE. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger individuals but co-morbid illnesses and the psychosocial effects of aging may affect the diagnosis, clinical presentation and care of asthma in this population. At least two phenotypes exist among elderly asthma; those with long-standing asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiological mechanisms of AIE are likely to be different from those seen in young asthmatics and these differences may influence the clinical course and outcomes of asthma in this population.

show abstract

“…There was a change in the muscarinic receptor subtypes and receptor coupling to G proteins with senescence [49]. Lee et al [50] found that the airway smooth muscle in young rats was more sensitive to cholinergic stimulation in vivo and in vitro compared to older rats, likely due to a higher expression of M 2 and M 3 muscarinic receptors in airway smooth muscle. Data on the effects of tiotropium in human older adults are not available.…”

Section: Age-related Pharmacodynamic Changesmentioning

confidence: 99%

Do We Need Different Treatments for Very Elderly COPD Patients?

Valente¹,

Pasciuto²,

Bernabei³

et al. 2010

Respiration

View full text Add to dashboard Cite

Population ageing is a new challenge for physicians because of the clinical complexity of the elderly. Although geriatric pharmacology is an emerging issue, very little is known and the choice of different treatments for the very elderly is still an important question. Chronic obstructive pulmonary disease is one of the most common chronic diseases throughout the world affecting prevalently older people. Despite the increasing burden of chronic obstructive pulmonary disease in older people, underdiagnosis and undertreatment in this age group are still common problems. Some patients are frail as they have impaired homeostatic mechanisms, deteriorated physiological systems, and limited functional reserve. Pharmacotherapeutic decisions should be combined with a careful assessment of comorbidity, polypharmacy, and age-related changes in pharmacokinetics and pharmacodynamics in order to minimize adverse drug events, drug-drug or drug-disease interactions, and nonadherence to treatment. There are few studies that specifically examine age as a factor influencing the pharmacokinetics and pharmacodynamics of inhaled therapies, the cornerstone of treatment for chronic obstructive pulmonary disease. This review provides a summary of age-related physiological changes and their impact on pharmacokinetics and pharmacodynamics, with particular regard to the drugs implicated in chronic obstructive pulmonary disease treatment, in order to optimize drug therapy.

show abstract

Age differences in cholinergic airway responsiveness in relation with muscarinic receptor subtypes

Cited by 7 publications

References 40 publications

Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model

Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model

Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop

Do We Need Different Treatments for Very Elderly COPD Patients?

Contact Info

Product

Resources

About