Age differences in drug binding by plasma proteins: Studies on human foetuses, neonates and adults

Ehrnebo, M.; Agurell, Stig; Jalling, Birgitta; Boréus, L. O.

doi:10.1007/bf00565004

Cited by 261 publications

(83 citation statements)

References 11 publications

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“…For example, Nau et al reported that the elevations in free fatty acids shortly after birth result in increased free fractions of diazepam and its main metabolite 27 . Ehrnebo et al reported that hyperbilirubinemia reduced the binding of a number of acidic drugs 26 . Elevated free fatty acids and bilirubin may explain some of the intersubject variance for a given drug within a population of infants, but these factors do not appear to be a global factor in the present analysis.…”

Section: Discussionmentioning

confidence: 99%

Protein binding predictions in infants

2002

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Section: Discussionmentioning

confidence: 99%

Protein binding predictions in infants

2002

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“…Plasma binding of propranolol was determined by equilibrium dialysis according to Ehrnebo et al (1971). Buffer (5 ,ul) containing 1.0 uCi [3H]-propranolol (10.8 ng) (Amersham) with a specific activity of 24 Ci/mmol was added to 1 ml of plasma.…”

Section: Plasma Binding Ofpropranololmentioning

confidence: 99%

Exercise‐induced increments in plasma levels of propranolol and noradrenaline.

Hurwitz¹,

Webb²,

Walle³

et al. 1983

Brit J Clinical Pharma

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Exercise‐induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise‐induced increments of 13 +/‐ 4% at 4 h after the last dose, 18 +/‐ 7% at 9 h and 41 +/‐ 5% at 16 h. Exercise‐induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise‐ induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action.

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“…activity in open-field behavior (DeLima and Neto,1980) . PUT given to mothers has been found to pass rapidly the placenta into the fetal circulation (Asoo, 1976) , and fetuses could be exposed to a higher concentration of free PHT (Ehrnebo et al, 1971) . Therefore, PHT given to the pregnant rats could affect the functional development of the fetal brain even when any morphological changes were not detected.…”

Section: Methodsmentioning

confidence: 99%