Age differences in renal response to atrial natriuretic peptide in rabbits

Semmekrot, B.A.; Wiesel, Paul; Monnens, L.A.H.; Guignard, Jean‐Pierre

doi:10.1016/0024-3205(90)90114-7

Cited by 22 publications

(12 citation statements)

References 21 publications

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“…This suggestion has been confirmed by Nushiro et al (1987), Seino et al (1988), who studied adult rabbits, and Kimura et al (1986), who experimented on adult dogs, and who have demonstrated that intravenously administered exogenous ANP triggers a growth in ERBF (ERPF). Using a similar experimental design, Eiskjaer et al (1996) and Janssen et al (1994) in adult humans, as well as Semmekrot et al (1990) in rabbits, observed these indices to decrease. On the other hand, no changes in renal blood (plasma) flow were found by Brown and Corr (1987) in humans, and by Dunn et al (1986) and Garcia-Estan and Roman (1990) in adult rats.…”

Section: Discussionmentioning

confidence: 83%

“…According to Dunn et al (1986) and Marin-Grez et al (1986), enhanced GFR may be a result of haemodynamics changes in the blood vessels of the glomeruli which lead to elevated glomerular filtration pressure. Conversely, Semmekrot et al (1990) observed decreasing GFR in young (4 -11 days old) and adult rabbits.…”

Section: Discussionmentioning

confidence: 88%

“…So far, it has not been clearly established whether and how atrial natriuretic peptide affects renal plasma filtration (Abu-Amarah and Balment 1999;Bidiville et al 1988;Chevalier et al 1988;Garcia-Estan and Roman 1990;Janssen et al 1994;Robillard et al 1988;Seino et al 1988;Semmekrot et al 1990). In our experiment, a lack of relationship was demonstrated between changes in ANP concentration in blood and glomerular filtration rate (coefficient of correlation non-significant at p ≤ 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…It has been recognised that ANP, through influence on glomerular afferent and efferent arterioles, may also affect renal blood (and plasma) flow and glomerular filtration rate (Dunn et al 1986;MarinGrez et al 1986). However, the literature provides discrepant information on the influence of ANP on renal haemodynamics (Abu-Amarah and Balment 1999; Eiskjaer et al 1996;Garcia-Estan and Roman 1990;Janssen et al 1994;Semmekrot et al 1990). It has also been published that an effect of exogenous ANP on renal blood (and plasma) flow and glomerular filtration rate may depend on the age of the examined individuals (Chevalier et al 1988;Robillard et al 1988;Semmekrot et al 1990).…”

mentioning

confidence: 99%

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Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves

Dratwa

2006

Acta Vet. Brno

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Dratwa A.: Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves. Acta Vet. Brno 2006, 75: 477-483.The study was aimed to provide information on the dynamics of changes in the concentration of ANP in blood plasma of calves during the first seven days of their life and to find any association between blood plasma ANP concentration and effective renal blood (ERBF) and plasma flow (ERPF) and glomerular filtration rate (GFR). The experiment was carried out on 10 clinically healthy Black and White calves during the first seven days of postnatal life. The concentration of atrial natriuretic peptide (ANP) in blood plasma was determined with radioimmunoassay. The kidney function was assessed by clearance methods, using para-aminohippuric acid and inulin. The blood plasma ANP concentration increased with age. On the first day the mean concentration of ANP was 5.72 ± 1.34 pmol/l, on the 7 th day it was 14.34 ± 2.09 pmol/l. The ERBF and ERPF during the first week of life showed variations, mean ERBF ranging within 280.22 ± 10.30 ml/min/m 2 (1 st day) and 338.25 ± 13.72 ml/min/m 2 (7 th day) and ERPF ranging between 179.77 ± 8.27 ml/min/m 2 (1 st day) and 245.22 ± 9.86 ml/min/m 2 (7 th day). The mean GFR on the first day was 35.68 ± 2.10 ml/min/m 2 and significantly (p ≤ 0.01) increased on the second day 49.97 ± 1.76 ml/min/m 2 , subsequently GFR remained on a stabile level average 51.06 ml/min/m 2 . The studies showed no correlations between plasma ANP concentration and ERPF (ERBF) and GFR. These data indicate that in calves during the first seven days of postnatal life endogenous ANP did not change the effective renal blood (plasma) flow and glomerular filtration rate.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves

Dratwa

2006

Acta Vet. Brno

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“…Endothelin, a potent vasoconstrictor peptide, has been recently isolated from cultured porcine endothelial cells (2). This peptide is approximately 100 times more potent than noradrenaline and 1000 times more active than neuropeptide Y on a molar basis in the rabbit microvasculature system (3).…”

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confidence: 99%

Effects of Endothelin on Renal Function in Newborn Rabbits

Thonney

et al. 1993

Pediatr Res

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ABSTRACT. The renal effects of endothelin-1 were investigated in 16 anesthetized and mechanically ventilated newborn rabbits. Renal blood flow and glomerular filtration rate were determined by the clearance of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In eight newborn rabbits, a bolus injection of 5 nmol.kg-' of endothelin-1 caused an initial fall in mean arterial blood pressure followed by a gradual, significant increase in mean arterial blood pressure that lasted for 45 min. The dramatic increase in renal vascular resistance (+28 f 4%) induced by endothelin led to a fall in glomerular filtration rate (-12 + 4%) and renal blood flow (-16 + 3%). In spite of the reduction of glomerular filtration rate and renal blood flow, urine flow and sodium excretion rates increased significantly (+20 f 5% and +49 f 9%, respectively). In eight additional newborn rabbits, a bolus injection of 1 nmol. kg-' of endothelin-a dose that usually induces marked renal and systemic vasoconstriction in adult models-did not affect systemic or renal hemodynamics. In conclusion, endothelin induces renal and systemic vasoconstriction and affects water and sodium homeostasis during the neonatal period. These effects occur under higher doses than those used in adult animals. This age difference in systemic and renal responsiveness is probably mediated by receptor immaturity and/or interference of high levels of counteracting hormones present during the neonatal period. (Pediatr Res 34: 120-123, 1993) Abbreviations CFR, glomerular filtration rate RBF, renal blood flow RPF, renal plasma flow FF, filtration fraction MBP, mean blood pressure RVR, renal vascular resistance PAH, paraaminohippuric acid V, urine flow rate UNaV, urinary sodium excretionThe immature kidney is exposed to various vasoactive systems such as the renin-angiotensin system, intrarenal adenosine, the prostaglandins, and atrial natriuretic peptide, which are hyper-

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Postnatal Renal Maturation

Baum

Anslow

2022

Pediatric Nephrology

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Age differences in renal response to atrial natriuretic peptide in rabbits

Cited by 22 publications

References 21 publications

Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves

Atrial Natriuretic Peptide and Renal Haemodynamics in Newborn Calves

Effects of Endothelin on Renal Function in Newborn Rabbits

Postnatal Renal Maturation

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