Age differences in the pulmonary and vascular pathophysiologic processes after long-term real-time exposure to particulate matter in rats

Xiao, Xue; Tong, Yao; Du, Shuaishuai; Zhang, Junxia; Huang, Tingting; Lei, Yali; Cao, Lei; Shen, Zhenxing; Cao, Ricardo

doi:10.1016/j.chemosphere.2020.127710

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Specifically, it may include PM 2.5 accumulation in the kidneys, endothelial dysfunction, renin-angiotensin system (RAS) abnormalities, and immune complex deposition. 13,30 PM 2.5 is mainly inhaled by the respiratory tract. Smaller particulate matter in PM 2.5 crosses the blood gas barrier, then transfers to the kidneys through the blood circulation, and accumulates in the kidneys.…”

Section: The Pathways Of Pm 25 Affecting Kidneymentioning

confidence: 99%

“…31 Accumulation of cadmium and chromium also occurred in the kidneys of mice exposed to PM 2.5 plus PM 10. 13 Although there is ample evidence for accumulation of PM 2.5 components in the kidney, how they enter the kidney remains to be further explored. It may be that macrophages endocytose PM 2.5 , which allows PM 2.5 to cross the blood gas barrier and eventually reach the kidneys.…”

Section: The Pathways Of Pm 25 Affecting Kidneymentioning

confidence: 99%

“…Specifically, it may include PM 2.5 accumulation in the kidneys, endothelial dysfunction, renin-angiotensin system (RAS) abnormalities, and immune complex deposition. 13,30…”

Section: Pm25 and Renal Injurymentioning

confidence: 99%

“…The deposition of particulate matter and its components in the body cause a systemic inflammatory response and vasodilation disorder. 13 Organophosphate esters (OPEs) are found in PM 2.5 . However, little is known about their toxic potentials on kidney, except adverse effects on renal proximal tubule cells.…”

Section: Introductionmentioning

confidence: 99%

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The influence of PM_2.5 exposure on kidney diseases

Wang

Jiang

et al. 2022

Hum Exp Toxicol

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The harm of air pollution to public health has become a research hotspot, especially atmospheric fine-particulate matter (PM2.5). In recent years, epidemiological investigations have confirmed that PM2.5 is closely related to chronic kidney disease and membranous nephropathy Basic research has demonstrated that PM2.5 has an impact on the normal function of the kidneys through accumulation in the kidney, endothelial dysfunction, abnormal renin-angiotensin system, and immune complex deposition. Moreover, the mechanism of PM2.5 damage to the kidney involves inflammation, oxidative stress, apoptosis, DNA damage, and autophagy. In this review, we summarized the latest developments in the effects of PM2.5 on kidney disease in human and animal studies, so as to provide new ideas for the prevention and treatment of kidney disease.

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Section: The Pathways Of Pm 25 Affecting Kidneymentioning

confidence: 99%

Section: The Pathways Of Pm 25 Affecting Kidneymentioning

confidence: 99%

“…Specifically, it may include PM 2.5 accumulation in the kidneys, endothelial dysfunction, renin-angiotensin system (RAS) abnormalities, and immune complex deposition. 13,30…”

Section: Pm25 and Renal Injurymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of PM_2.5 exposure on kidney diseases

Wang

Jiang

et al. 2022

Hum Exp Toxicol

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“…In addition, some epidemiological studies have demonstrated an association between PM 2.5 exposure and elevated blood pressure [ 9 , 10 ] and pulmonary arterial pressure [ 11 , 12 ]. Animal studies have reported that exposure to PM increased blood pressure [ 13 , 14 ]. Therefore, we hypothesized that vascular cells are targets of PM.…”

Section: Introductionmentioning

confidence: 99%

Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-κB Dependent and Independent Pathways: Protective Effects of Polyphenols

Chen

Tsai

et al. 2021

Antioxidants

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Epidemiological studies have demonstrated an association between ambient particulate matter (PM) exposure and vascular diseases. Here, we observed that treatment with ambient PM increased cell migration ability in vascular smooth muscle cells (VSMCs) and pulmonary arterial SMCs (PASMCs). These results suggest that VSMCs and PASMCs transitioned from a differentiated to a synthetic phenotype after PM exposure. Furthermore, treatment with PM increased intracellular reactive oxygen species (ROS), activated the NF-κB signaling pathway, and increased the expression of proinflammatory cytokines in VSMCs. Using specific inhibitors, we demonstrated that PM increased the migration ability of VSMCs via the nicotinamide–adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX1)/ROS-dependent NF-κB signaling pathway, which also partially involved in the induction of proinflammatory cytokines. Finally, we investigated whether nature polyphenolic compounds prevent PM-induced migration and proinflammatory cytokines secretion in VSMCs. Curcumin, resveratrol, and gallic acid prevented PM2.5-induced migration via the ROS-dependent NF-κB signaling pathway. However, honokiol did not prevent PM2.5-induced migration or activation of the ROS-dependent NF-κB signaling pathway. On the other hand, all polyphenols prevented PM2.5-induced cytokines secretion. These data indicated that polyphenols prevented PM-induced migration and cytokine secretion via blocking the ROS-dependent NF-κB signaling pathway in VSMCs. However, other mechanisms may also contribute to PM-induced cytokine secretion.

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Advances in the Toxicological Studies of Atmospheric Particulate Matter

et al. 2022

Advances in Toxicology and Risk Assessment of Nanomaterials and Emerging Contaminants

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Age differences in the pulmonary and vascular pathophysiologic processes after long-term real-time exposure to particulate matter in rats

Cited by 12 publications

References 22 publications

The influence of PM_2.5 exposure on kidney diseases

The influence of PM_2.5 exposure on kidney diseases

Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-κB Dependent and Independent Pathways: Protective Effects of Polyphenols

Advances in the Toxicological Studies of Atmospheric Particulate Matter

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Age differences in the pulmonary and vascular pathophysiologic processes after long-term real-time exposure to particulate matter in rats

Cited by 12 publications

References 22 publications

The influence of PM2.5 exposure on kidney diseases

The influence of PM2.5 exposure on kidney diseases

Ambient Particulate Matter Induces Vascular Smooth Muscle Cell Phenotypic Changes via NOX1/ROS/NF-κB Dependent and Independent Pathways: Protective Effects of Polyphenols

Advances in the Toxicological Studies of Atmospheric Particulate Matter

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The influence of PM_2.5 exposure on kidney diseases

The influence of PM_2.5 exposure on kidney diseases