Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors

Pilleron, Sophie; Maringe, Camille; Charvat, Hadrien; Atkinson, June; Morris, Eva; Sarfati, Diana

doi:10.1016/j.lungcan.2021.05.015

Cited by 19 publications

(26 citation statements)

References 37 publications

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“…Multivariable Cox regression analysis showed that seven clinical factors including age, gender, marital status, T stage, N stage, surgical type, and radiation were signi cantly associated with OS. Among them, patients aged >77 years presented a signi cantly higher risk of death than those aged <67, implying that age is a poor prognostic factor for lung squamous cell carcinoma, which is consistent with previous studies [29,30]. Many studies revealed sex differences existing in survival and female lung cancer patients have higher survival [31,32].…”

Section: Discussionsupporting

confidence: 86%

A nomogram for predicting postoperative overall survival of patients with lung squamous cell carcinoma: a SEER-based study

Rao

Zhang

et al. 2022

Preprint

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Background: Lung squamous cell carcinoma (LSCC) is a common subtype of non-small cell lung cancer. Our study aimed to construct and validate a nomogram for predicting overall survival (OS) for postoperative LSCC patients. Methods: A total of 8,078 patients eligible for recruitment between 2010 and 2015 were selected from the Surveillance, Epidemiology and End Results database. The study outcomes were 1-, 2-, and 3-year OS. Analyses performed included univariable and multivariable Cox regression, receiver the operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA), and Kaplan-Meier survival curves.Results: Seven variables were selected to establish the nomogram for LSCC. The area under the curve in ROC curve revealed 0.658, 0.651, and 0.647 in the training cohort and 0.673, 0.667, and 0.658 in the validation cohort at 1-, 2-, and 3-year survival. The calibration curves showed satisfactory consistencies between nomogram-predicted and observed survival probability. DCA showed great clinical net benefit. In risk stratification systems, patients were divided into three risk groups with a significant difference in OS in Kaplan-Meier curves (P＜0.001).Conclusions: A prognostic nomogram for OS of postoperative LSCC patients was developed and validated, which may assist clinicians in evaluating prognosis and providing highly individualized therapy.

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Section: Discussionsupporting

confidence: 86%

A nomogram for predicting postoperative overall survival of patients with lung squamous cell carcinoma: a SEER-based study

Rao

Zhang

et al. 2022

Preprint

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“…Women’s median survival time and 3-year, 5-year, and 10-year survival rates were more significant and growing faster than men’s. Pilleron et al 18 also found that gender was one of the most important factors influencing lung cancer survival time. The prognosis of female patients undergoing lobectomy/segmentectomy was significantly better than in male patients.…”

Section: Discussionmentioning

confidence: 97%

Prognosis and Survival Analysis of 922,317 Lung Cancer Patients from the US Based on the Most Recent Data from the SEER Database (April 15, 2021)

Sheng¹,

Zhang²,

Guo³

et al. 2021

IJGM

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Background On April 15, 2021, the Surveillance, Epidemiology, and End Results (SEER) database released the latest lung cancer follow-up data. We selected 922,317 lung cancer patients diagnosed from 2000 to 2017 for survival analysis to provide updated data for lung cancer researchers. Research Question This study explored the latest trends of survival time in terms of gender, race, nationality, age, income, address, histological type and primary site. Study Design and Methods The SEER database covers 27.8% of the US population. We used life table, Kaplan–Meier, log-rank, Breslow and Tarone-Ware tests to calculate survival rate, time, and curve and to compare differences in survival distribution. We performed univariate and multivariate Cox proportional hazards analyses. Results The median survival time of all lung cancer patients diagnosed in 2017 increased by 41.72% compared to 2000. Median survival time of female patients diagnosed in 2017 increased by 70.94% compared to 2000. Median survival time of those diagnosed in 2017 for different primary sites was as follows: right middle lobe was the longest, then left lower lobe, right upper lobe, right lower lobe, and left upper lobe. Lung cancer patients older than 75 years had a significantly shorter median survival time. Patients living in metropolitan areas of 250,000 to 1 million had a longer median survival time. Median survival time in the adenocarcinoma group was significantly greater than other patients. Median survival of Asian and other races diagnosed in 2017 was 97.87% higher than those diagnosed in 2000. Survival rate of lung cancer increased gradually with the year of diagnosis. Interpretation The rapid improvement of the prognosis of female and young lung cancer patients contributes to the improvement of the overall prognosis. Primary lung cancer in the right middle lobe has the best prognosis.

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“…Our results were highly consistent with previous results [ 15 ]. Previous research found that patients who were older at onset had more comorbidities, poorer performance status, lower tolerance of treatment and a worse prognosis [ 23 , 24 ]. Some studies have reported a worse prognosis in females than males [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Sublobar resection versus lobectomy for patients with stage T1-2N0M0 pulmonary typical carcinoid tumours: a population-based propensity score matching analysis

Yang

Mei

2022

Interactive CardioVascular and Thoracic Surgery

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Objectives It is widely accepted that surgical resection of localized pulmonary typical carcinoid (TC) tumours remains the primary curative modality. However, the optimal extent of resection remains controversial. This study aimed to investigate the survival rates of patients with stage T1-2N0M0 TC tumours who underwent sublobar resection or lobectomy. Methods We queried the Surveillance, Epidemiology, and End Results database for patients who underwent surgery after being diagnosed with stage T1-2N0M0 TCs from 2004 to 2016. Propensity score matching (PSM) analysis was used to equalize baseline characteristics between the sublobar resection group and the lobectomy group. Kaplan–Meier analysis and the Cox proportional hazard model were performed for survival analysis. Results Of the 2469 patients included, 658 (26.65%) underwent sublobar resection and 1811 (73.35%) underwent lobectomy. All 2469 patients were analysed with PSM and, following PSM, 812 patients were included in the final analysis, divided into two groups of 406 patients. In the matched cohort, Kaplan–Meier analysis demonstrated no significant difference in survival curves between the sublobar resection and lobectomy groups in patients with stage T1-2N0M0 TC tumours (5-year OS = 90.78% versus 93.30%; HR 1.18, 95% CI: 0.77–1.80; P = 0.505). Subgroup analysis by tumour size showed that the sublobar resection group was identical to the lobectomy group in overall survival (OS) for tumours ≤3.0 cm. In addition, no difference in OS between surgical groups was observed in any subgroups. In multivariable Cox analysis, age ≤ 65y, female sex, married status, and adequate lymph node assessment (≥5) were associated with improved OS, whereas the extent of resection was not. Conclusions Sublobar resection seems to be associated with similar survival to lobectomy for stage T1-2N0M0 TC tumours if lymph node assessment is performed adequately. This analysis suggests sublobar resection should be considered an appropriate alternative for stage T1-2N0M0 TC tumours. However, further validations are needed in large, multicentre prospective studies.

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Age disparities in lung cancer survival in New Zealand: The role of patient and clinical factors

Cited by 19 publications

References 37 publications

A nomogram for predicting postoperative overall survival of patients with lung squamous cell carcinoma: a SEER-based study

A nomogram for predicting postoperative overall survival of patients with lung squamous cell carcinoma: a SEER-based study

Prognosis and Survival Analysis of 922,317 Lung Cancer Patients from the US Based on the Most Recent Data from the SEER Database (April 15, 2021)

Sublobar resection versus lobectomy for patients with stage T1-2N0M0 pulmonary typical carcinoid tumours: a population-based propensity score matching analysis

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