Age Distribution of Patients Presenting With Typhoid and Paratyphoid Fever in Kathmandu, Nepal

Abstract

Background: Enteric fever is a significant cause of morbidity in Nepal. In the past, Salmonella entericaserovar Typhi (S. Typhi) was the major causative organism of enteric fever. However, more recently, Salmonella entericaserovar Paratyphi (S.Paratyphi) A has been isolated from most patients presenting with enteric fever in various regions of Nepal. This study aimed to evaluate age differences in patients presenting with typhoid and paratyphoid fever.Materials & Methods: Between December 2014 and October 2015, 186 patients presented with enteric fever to the Civil Service Hospital in Kathmandu. S. Typhi and S.Paratyphi A were isolated from blood cultures in 48.4% and 51.6% of the cases, respectively. Age groups of the patients infected with either serovar were compared.Results: The mean age of patients from whom S. Typhi was isolated was 19.3 years, while the mean age of patients from whom S. Paratyphi A was isolated was 25.2 years; p=0.025.Conclusion: Our study shows that age is an important factor in having either typhoid or paratyphoid fever. This will help in the prevention of typhoid and paratyphoid fever in various age groups.Journal of Nobel Medical CollegeVolume 6, Number 2, Issue 11 (July-December, 2017) Page:25-28

Antimicrobial Resistance in Salmonella Typhi Isolated From a Referral Hospital of Kathmandu, Nepal

“…34 In this study, it was found that majority of typhoid fever cases accounted to the age-group of 11 to 30 years as revealed by various other studies from Nepal. [35][36][37][38] Even though more than half of the blood cultures were obtained from patients >30 years of age, S. Typhi was not found to be culture positive from this age-group. Persons of age group 15 to 30 are often engaged in outdoor activities and are more inclined to consumption of foods from street or local vendors which can significantly contribute to higher incidence of typhoid fever.…”