Age effect on the default mode network, inner thoughts, and cognitive abilities

Mevel, Katell; Landeau, Brigitte; Fouquet, Marine; Joie, Renaud La; Villain, Nicolas; Mézenge, Florence; Perrotin, Audrey; Eustache, Francis; Desgranges, Béatrice; Chételat, Gaël

doi:10.1016/j.neurobiolaging.2012.08.018

Cited by 115 publications

(99 citation statements)

References 40 publications

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“…Reduced connectivity of mPFC node from temporal and posterior parts of DMN in aged subjects was evident even with a relatively low number of subjects (in sample 2 ). Group comparisons suggested that the most significant effect of age was present in the coupling between mPFC and posterior midline structures, in agreement with other studies (Andrews-Hanna et al, 2007; Tomasi and Volkow, 2012; Campbell et al, 2013; Mevel et al, 2013). These areas form the nucleus of DMN which is composed by other several subsystems (Laird et al, 2009) involving temporal, superior frontal and lateral parietal cortices.…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, age-related reductions in DMN nodes seems to involve coupling between mPFC and posterior midline structures in particular, which are the key nodes of the DMN (Andrews-Hanna et al, 2007; Bluhm et al, 2008; Biswal et al, 2010; Campbell et al, 2013; Mevel et al, 2013). Default Mode Network rs-fMRI connectivity predicts cognitive and behavioral measures, especially memory function, both in different populations including healthy young subjects (Sala-Llonch et al, 2012) and healthy elders (Andrews-Hanna et al, 2007; Damoiseaux et al, 2008; Wang et al, 2010; He et al, 2012; Mevel et al, 2013; Razlighi et al, 2014). Alterations in the DMN, a core brain network, have been attributed to inefficient reallocation of resources, though the exact causes of decreased DMN are still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes

Vidal-Piñeiro

Valls-Pedret

Fernández-Cabello

et al. 2014

Front. Aging Neurosci.

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Ageing entails cognitive and motor decline as well as brain changes such as loss of gray (GM) and white matter (WM) integrity, neurovascular and functional connectivity alterations. Regarding connectivity, reduced resting-state fMRI connectivity between anterior and posterior nodes of the Default Mode Network (DMN) relates to cognitive function and has been postulated to be a hallmark of ageing. However, the relationship between age-related connectivity changes and other neuroimaging-based measures in ageing is fragmentarily investigated. In a sample of 116 healthy elders we aimed to study the relationship between antero-posterior DMN connectivity and measures of WM integrity, GM integrity and cerebral blood flow (CBF), assessed with an arterial spin labeling sequence. First, we replicated previous findings demonstrating DMN connectivity decreases in ageing and an association between antero-posterior DMN connectivity and memory scores. The results showed that the functional connectivity between posterior midline structures and the medial prefrontal cortex was related to measures of WM and GM integrity but not to CBF. Gray and WM correlates of anterio-posterior DMN connectivity included, but were not limited to, DMN areas and cingulum bundle. These results resembled patterns of age-related vulnerability which was studied by comparing the correlates of antero-posterior DMN with age-effect maps. These age-effect maps were obtained after performing an independent analysis with a second sample including both young and old subjects. We argue that antero-posterior connectivity might be a sensitive measure of brain ageing over the brain. By using a comprehensive approach, the results provide valuable knowledge that may shed further light on DMN connectivity dysfunctions in ageing.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes

Vidal-Piñeiro

Valls-Pedret

Fernández-Cabello

et al. 2014

Front. Aging Neurosci.

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“…In accordance with previous work on the relation between cognitive capacity and the negative BOLD response in DMN, for example studies on normal aging [43,44], we suggest that insufficient suppression of DMN is related to the language impairment that was observed in GE participants in the present study.…”

Section: Inadequate Negative Bold Responsesupporting

confidence: 93%

“…However, it is not only the presence of correlated, task-positive brain networks that governs performance. Increasing evidence supports the hypothesis that anti-correlated networks are as important for human brain function as correlated networks [20,43,44].…”

Section: Inadequate Negative Bold Responsementioning

confidence: 87%

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Gauffin¹,

Ettinger-Veenstra²,

Landtblom³

et al. 2013

Epilepsy & Behavior

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We aimed to study the effect of a potential default mode network (DMN) dysfunction on language performance in epilepsy. Language dysfunction in focal epilepsy has previously been connected to brain damage in language associated cortical areas. In this work, we studied generalized epilepsy (GE) without focal brain damage, to see if the language function was impaired.We used functional magnetic resonance imaging (fMRI) to investigate if the DMN was involved. Eleven persons with GE and 28 healthy controls were examined with fMRI during a sentence reading task. We could demonstrate impaired language function, reduced suppression of DMN, and, specifically, an inadequate suppression of activation in the left anterior temporal lobe and the posterior cingulate cortex, as well as an aberrant activation in the right hippocampal formation. Our results highlight the presence of language decline in people with epilepsy of not only focal, but also generalized origin.

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“…During normal aging (i.e., in the absence of neurodegenerative disease), individuals with marked reductions in DMN connectivity also show significant cognitive decline relative to age-matched subjects with stronger FC (7)(8)(9). This relationship appears particularly robust for associative memory (10)(11)(12), where the strength of temporal coherence between the hippocampus and posteriomedial areas of the DMN (i.e., the precuneus and cingulate cortex) predicts face-name memory performance (12). Although rs-dynamics are also disrupted in a number of other conditions (for a review, see ref.…”

mentioning

confidence: 99%

Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats

Ash

Taxier

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Changes in the functional connectivity (FC) of large-scale brain networks are a prominent feature of brain aging, but defining their relationship to variability along the continuum of normal and pathological cognitive outcomes has proved challenging. Here we took advantage of a well-characterized rat model that displays substantial individual differences in hippocampal memory during aging, uncontaminated by slowly progressive, spontaneous neurodegenerative disease. By this approach, we aimed to interrogate the underlying neural network substrates that mediate aging as a uniquely permissive condition and the primary risk for neurodegeneration. Using resting state (rs) blood oxygenation level-dependent fMRI and a restrosplenial/posterior cingulate cortex seed, aged rats demonstrated a large-scale network that had a spatial distribution similar to the default mode network (DMN) in humans, consistent with earlier findings in younger animals. Between-group whole brain contrasts revealed that aged subjects with documented deficits in memory (aged impaired) displayed widespread reductions in cortical FC, prominently including many areas outside the DMN, relative to both young adults (Y) and aged rats with preserved memory (aged unimpaired, AU). Whereas functional connectivity was relatively preserved in AU rats, they exhibited a qualitatively distinct network signature, comprising the loss of an anticorrelated network observed in Y adults. Together the findings demonstrate that changes in rs-FC are specifically coupled to variability in the cognitive outcome of aging, and that successful neurocognitive aging is associated with adaptive remodeling, not simply the persistence of youthful network dynamics.resting-state fMRI | default mode network | functional connectivity | neurocognitive aging | rat model F unctional MRI (fMRI) has revealed a number of functionally interconnected brain networks. One prominent example, termed the default mode network (DMN), shows prominent temporally coherent activity under wakeful, spontaneous, and undirected conditions (i.e., "resting"), and decreased coherence in response to active cognitive engagement (1-3). Functional connectivity (FC) assessed from the blood oxygenation level-dependent (BOLD) signal provides a measure of these coincident fluctuations across brain areas (2, 4), where positive correlations are thought to reflect simultaneous neuronal activity between regions, and negative or "anticorrelations" arise from inverse, antiphase fluctuations. In this way, resting-state FC (rs-FC) maps the temporal and spatial organization of large-scale neural network dynamics.Recent studies indicate that variability in DMN FC is linked to individual differences in cognition and behavior (e.g., refs. 5 and 6), including differential trajectories of cognitive aging. For example, the strength of FC between anterior and posterior components of the DMN across the lifespan is directly related to performance on tasks measuring executive function, memory, and processing speed (7). During normal ag...

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Age effect on the default mode network, inner thoughts, and cognitive abilities

Cited by 115 publications

References 40 publications

Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes

Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes

Impaired language function in generalized epilepsy: Inadequate suppression of the default mode network

Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats

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