Age Effect upon Cementum Width of Albino Rat: A Histometric Study

Louridis, O; Bazopoulou-Kyrkanidou, Euterpe; Demetriou, Nlkitas

doi:10.1902/jop.1972.43.9.533

Cited by 25 publications

(12 citation statements)

References 13 publications

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“…load-bearing organs well into function), extraneous loads and significant deviations from physiological threshold limits could affect the form or shape of load bearing functional units [37]. Age-related changes in organ biomechanics, were related to the changes in PDL mechanical properties, turnover rate, PDL-width and density [38], along with increased cementum apposition [39]. However, the common denominator for all developed periodontal tissues is functional load.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Adaptation of Bone-PDL-Tooth Complex: Rattus-Norvegicus as a Model System

et al. 2012

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Functional loads on an organ induce tissue adaptations by converting mechanical energy into chemical energy at a cell-level. The transducing capacity of cells alters physico-chemical properties of tissues, developing a positive feedback commonly recognized as the form-function relationship. In this study, organ and tissue adaptations were mapped in the bone-tooth complex by identifying and correlating biomolecular expressions to physico-chemical properties in rats from 1.5 to 15 months. However, future research using hard and soft chow over relevant age groups would decouple the function related effects from aging affects. Progressive curvature in the distal root with increased root resorption was observed using micro X-ray computed tomography. Resorption was correlated to the increased activity of multinucleated osteoclasts on the distal side of the molars until 6 months using tartrate resistant acid phosphatase (TRAP). Interestingly, mononucleated TRAP positive cells within PDL vasculature were observed in older rats. Higher levels of glycosaminoglycans were identified at PDL-bone and PDL-cementum entheses using alcian blue stain. Decreasing biochemical gradients from coronal to apical zones, specifically biomolecules that can induce osteogenic (biglycan) and fibrogenic (fibromodulin, decorin) phenotypes, and PDL-specific negative regulator of mineralization (asporin) were observed using immunohistochemistry. Heterogeneous distribution of Ca and P in alveolar bone, and relatively lower contents at the entheses, were observed using energy dispersive X-ray analysis. No correlation between age and microhardness of alveolar bone (0.7±0.1 to 0.9±0.2 GPa) and cementum (0.6±0.1 to 0.8±0.3 GPa) was observed using a microindenter. However, hardness of cementum and alveolar bone at any given age were significantly different (P<0.05). These observations should be taken into account as baseline parameters, during development (1.5 to 4 months), growth (4 to 10 months), followed by a senescent phase (10 to 15 months), from which deviations due to experimentally induced perturbations can be effectively investigated.

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Section: Introductionmentioning

confidence: 99%

Age-Related Adaptation of Bone-PDL-Tooth Complex: Rattus-Norvegicus as a Model System

et al. 2012

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“…In rats, as in man, apposition of cementum continues throughout life, the rate of increase in tissue width being greater in younger animals [Louridis et al, 1972], In the present study of 3-week-old rats, the fluoride distribution was examined in the cementum formed during the experi mental period. The fluoride concentration in the outer most layer of cementum tended to fluctuate because of the rough surface of the tissue and the presence of peri odontal ligaments.…”

Section: Discussionmentioning

confidence: 90%

Influence of Occlusion on the Fluoride Distribution in Rat Molar Cementum

Kato

Nakagaki²,

Okumura³

et al. 1992

Caries Res

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This study was undertaken to examine the influence of occlusion on the fluoride distribution in cementum following an experiment in which the occlusion in rats was locally altered by extracting the upper left molar. These and control rats with normal occlusion were given water containing 0 or 100 ppm fluoride for 12 weeks. The fluoride distributions in cementum from both first lower molars of the same animal were compared. The fluoride concentrations had increased throughout the tissue as a result of increased fluoride administration, irrespective of any changes in occlusion. They were, as usual, generally highest at or near the cementum surface and decrease towards the interior of the tissue. Where there had been a change in occlusion, the thickness of cementum was less than that of the contralateral tooth, but, despite this, the fluoride profiles in contralateral teeth were similar in both experimental and control rats. In the experimental rats, on the other hand, the total fluoride tended to be lower, and the mean fluoride tended to be higher in left molars without antagonists. These findings were never seen in the control rats. It was concluded that the alteration in occlusion influenced the fluoride distribution in the cementum through its effect on the rate of cementum formation.

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“…Mesial or distal sites were not used for evaluating the thickness of cementum as it has been found that the mean cementum width on the mesial side of the root is slightly less than on the distal side which seems to represent a functional effect related to mesioocclusal migration of the teeth. [14] Rate of development of extrinsic cementum at distal sites has been shown to be three times than at mesial sites. [15] Thus, the thickness of cementum was assessed only on the labial aspect of tooth.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of thickness of cementum of periodontally diseased teeth of non-diabetic and type 2 diabetic patients: A scanning electron microscopy study

Gupta¹,

Galgali²,

Bavle³

et al. 2013

J Indian Soc Periodontol

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Background:It is suggested that diabetes plays an important role in tooth loss. The periodontal structure and alveolar bone architecture in diabetics have revealed alterations. However, changes in cementum of diabetics with periodontal disease have not been evaluated adequately. Thus, the aim of the study is to evaluate and compare the thickness of cementum in diseased and healthy areas of roots of teeth with chronic periodontitis from non-diabetic (group I) and type 2 diabetic patients (group II).Materials and Methods:Thirty incisors indicated for extraction as a result of chronic periodontitis from group I and group II were selected. Measurements of Probing Depth (PD) and Clinical Attachment Loss (CAL) were taken prior to extractions. Area of the root surface above the CAL (notch) was designated as diseased, while the area below the CAL (notch) was designated as healthy. The extracted tooth samples were sectioned longitudinally and were evaluated by scanning electron microscopy (SEM). Descriptive statistical analysis was performed. Results of continuous measurements were presented as Mean ± SD.Results:The results showed that in both groups the thickness of cementum in diseased areas was lower in comparison to the thickness in healthy areas. The mean thickness of cementum in both healthy and diseased areas was higher in group II compared to group I, though the differences in both were not statistically significant.Conclusion:Within the limits of the present study, group II showed greater mean thickness of cementum in both healthy and diseased areas compared to group I, though the differences were not statistically significant.

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Age Effect upon Cementum Width of Albino Rat: A Histometric Study

Cited by 25 publications

References 13 publications

Age-Related Adaptation of Bone-PDL-Tooth Complex: Rattus-Norvegicus as a Model System

Age-Related Adaptation of Bone-PDL-Tooth Complex: Rattus-Norvegicus as a Model System

Influence of Occlusion on the Fluoride Distribution in Rat Molar Cementum

Evaluation of thickness of cementum of periodontally diseased teeth of non-diabetic and type 2 diabetic patients: A scanning electron microscopy study

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