Research on non-governmental organizations (NGOs) largely focuses on the actions taken towards contributing to social change in communities and has characterized them into a typology of resisters or cooperators. Using extensive qualitative data, I use this case study to illustrate that NGOs use multiple repertoires of strategies that range from low to high risk. In this article, I show how and why NGO leaders in Monterrey, Mexico, choose their strategies based on their interpretation of the local sociopolitical environment and their assessment of how politically challenging a goal is within that context. By setting aside the dichotomy of NGOs as cooperators or resisters, I demonstrate the connection between strategies, goals, and the local sociopolitical context that is largely missing in our theorizing of NGOs (and other forms of collective action). These findings have implications for understanding how NGOs, as social actors, participate in an increasingly complex and interconnected global space.