Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry

Li, Yangjiani; Hall, Nathan; Pershing, Suzann; Hyman, Leslie; Haller, Julia A.; Lee, Aaron; Lee, Cecilia S.; Chiang, Michael F.; Lum, Flora; Miller, Joan W.; Lorch, Alice C.; Elze, Tobias

doi:10.1016/j.oret.2021.05.004

Cited by 32 publications

(24 citation statements)

References 43 publications

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“…We found that the SHAP values suggested that ocular laterality was a prominent factor in the predictive model, particularly that derived from the arterial system, it could be hypothesized that hemodynamic phenomena depend on physiologically inherent asymmetry in vascular dynamics play an important role in the optimization of cardiovascular functions [ 116 , 117 ]. Recent studies have demonstrated the association between ocular laterality on retinal vascular occlusions [ 118 , 119 ]. Although there are anatomic reasons for retinal arterial occlusions pertaining to embolic etiologies, the reason why asymmetry plays a role in the arterial rather than the venous system remains unclear.…”

Section: Discussionmentioning

confidence: 99%

A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography

Abdul-Rahman

Morgan

2022

PLoS ONE

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The ideal Intracranial pressure (ICP) estimation method should be accurate, reliable, cost-effective, compact, and associated with minimal morbidity/mortality. To this end several described non-invasive methods in ICP estimation have yielded promising results, however the reliability of these techniques have yet to supersede invasive methods of ICP measurement. Over several publications, we described a novel imaging method of Modified Photoplethysmography in the evaluation of the retinal vascular pulse parameters decomposed in the Fourier domain, which enables computationally efficient information filtering of the retinal vascular pulse wave. We applied this method in a population of 21 subjects undergoing lumbar puncture manometry. A regression model was derived by applying an Extreme Gradient Boost (XGB) machine learning algorithm using retinal vascular pulse harmonic regression waveform amplitude (HRWa), first and second harmonic cosine and sine coefficients (an1,2, bn1,2) among other features. Gain and SHapley Additive exPlanation (SHAP) values ranked feature importance in the model. Agreement between the predicted ICP mean, median and peak density with measured ICP was assessed using Bland-Altman bias±standard error. Feature gain of intraocular pressure (IOPi) (arterial = 0.6092, venous = 0.5476), and of the Fourier coefficients, an1 (arterial = 0.1000, venous = 0.1024) ranked highest in the XGB model for both vascular systems. The arterial model SHAP values demonstrated the importance of the laterality of the tested eye (1.2477), which was less prominent in the venous model (0.8710). External validation was achieved using seven hold-out test cases, where the median venous predicted ICP showed better agreement with measured ICP. Although the Bland-Altman bias from the venous model (0.034±1.8013 cm water (p<0.99)) was lower compared to that of the arterial model (0.139±1.6545 cm water (p<0.94)), the arterial model provided a potential avenue for internal validation of the prediction. This approach can potentially be integrated into a neurological clinical decision algorithm to evaluate the indication for lumbar puncture.

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Section: Discussionmentioning

confidence: 99%

A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography

Abdul-Rahman

Morgan

2022

PLoS ONE

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“…29 The resultants ocular diseases were with higher incidence than in the normal population which focuses the cause on the COVID-19 infection. 30,31 Some reports suggested the occurrence of endogenous endophthalmitis postcovid. 32 Some reported ocular surface abnormalities after a COVID-19 infection, such as the occurrence of dryness and alternation in the osmolarity of the tears.…”

Section: Discussionmentioning

confidence: 99%

Ocular Manifestations of Post-Acute COVID-19 Syndrome, Upper Egypt Early Report

Tohamy¹,

Sharaf²,

Abdelazeem³

et al. 2021

JMDH

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Purpose To evaluate the ocular manifestations of post-acute COVID-19 syndrome. Methods A retrospective, comparative study included 100 patients who had recovered from COVID-19 and 100 controls who were recruited by stratified randomization from hospital registration system and analyzed regarding history, full ophthalmological examination, general examination including internal medicine and neurological evaluation. Laboratory tests were done. Results Mean±SD of age were 55.5 ± 6.2 in COVID group vs 56.5 ± 5.8 in control group; P value = 0.7. In COVID group, 57 patients (57%) were males vs 51 patients (51%) in control group (P value = 0.39), the other compared parameters including history and risk factors showed non-significant difference except for ESR and D-dimer which were elevated in COVID group. In COVID group, 5 patients (5%) were having retinal vascular occlusion, 2 patients (2%) were having anterior ischemic optic neuropathy AION, 3 patients (3%) were having uveitis and 2 patients (2%) were having central serous chorioretinopathy CSCR. While in control group, 2 patients (2%) were having retinal vascular occlusion, and none had AION, uveitis or CSCR (P value = 0.006). Conclusion Post-acute COVID-19 syndrome could affect the eyes in the form of coagulation problems, neurological morbidities, and other manifestations. This necessitates meticulous follow-up of recovered patients from COVID-19.

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“…Another recent study of CRVO in Japan also showed that the prevalence was higher in men (64.7%) than women (35.3%) [ 19 ], whereas global epidemiological studies have shown that the prevalence of CRVO did not differ significantly between the sexes [ 5 , 7 ]. Real-world reports of CRVO in the USA [ 15 ], UK [ 26 ], and Germany [ 13 ] also reported no significant difference in the prevalence of CRVO between men and women, although recent results of the IRIS registry reported that the prevalence of CRVO was slightly, but significantly, higher in men (50.4%) than women (49.6%) [ 28 ]. We assume that the higher prevalence of CRVO in men in Japan may be related to the higher prevalence of hypertension and smoking in men in Japan [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…We need to consider the possibility that the poor initial BCVA in the right eye might be just a simple coincidence due to the small sample size. However, the results of the recent IRIS Registry demonstrated that there was a significant laterality between the right and left eyes in CRVO [ 28 ]. For example, the incidence of CRVO was not the same between the right and left eye, but was significantly higher in the left eye (49.1% vs. 50.9%).…”

Section: Discussionmentioning

confidence: 99%

Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan

Kondo

Noma

Shimura

et al. 2021

JCM

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Purpose: To determine the baseline characteristics of patients with central retinal vein occlusion (CRVO) that were significantly associated with the best-corrected visual acuity (BCVA) at the initial examination. Methods: This was a retrospective multicenter study using the medical records registered in 17 ophthalmological institutions in Japan. Patients with untreated CRVO (≥20-years-of-age) who were initially examined between January 2013 and December 2017 were studied. The patients’ baseline factors that were significantly associated with the BCVA at the initial examination were determined by univariate and multivariate linear regression analyses. Results: Data from 517 eyes of 517 patients were analyzed. Univariate analyses showed that an older age (r = 0.194, p < 0.001) and the right eye (r = −0.103, p < 0.019) were significantly associated with poorer BCVA at the initial visit. Multivariate analyses also showed that an older age (β = 0.191, p < 0.001) and the right eye (β = −0.089, p = 0.041) were significantly associated with poorer BCVA at the initial visit. Conclusions: The results indicate that an older age, a known strong factor, and the right eye were significantly associated with poorer BCVA at the initial visit to the hospital. These results suggest that functional and/or anatomical differences between the right and left eyes may be involved in these results.

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Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry

Cited by 32 publications

References 43 publications

A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography

A machine learning approach in the non-invasive prediction of intracranial pressure using Modified Photoplethysmography

Ocular Manifestations of Post-Acute COVID-19 Syndrome, Upper Egypt Early Report

Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan

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