Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women

Iki, Masayuki; Kajita, Etsuko; Dohi, Yoshiko; Nishino, Harumi; Kusaka, Yukinori; Tsuchida, Chika; Yamamoto, Kazutaka; Ishii, Yasushi

doi:10.1016/0378-5122(96)01042-0

Cited by 48 publications

(22 citation statements)

References 44 publications

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“…On ISS, average bone mineral density is lost at an average rate of about 0.9% per month in the lumbar spine and 1.4% per month in the femoral neck [12]. For comparison, a postmenopausal woman experiences losses of bone mineral on the order of 1% per year (e.g., [50]). The study has also shown regions of greatest bone mass loss during a mission and different rates of loss in different parts of the bone [12].…”

Section: Sub-regional Assessment Of Bone Loss In the Axial Skeleton Imentioning

confidence: 99%

Recent research accomplishments on the International Space Station

Robinson

Rhatigan

Baumann

2005

2005 IEEE Aerospace Conference

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This paper addresses the recent research results and accomplishments; and discusses the unique challenges faced in these early years of ISS assembly, including the methods for conduct of research while the Space Shuttle is unavailable as a resource for deploying and returning experiments for the ISS. We also discuss how the research portfolio is being realigned to support the use of ISS to enable NASA's Exploration Mission.

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Section: Sub-regional Assessment Of Bone Loss In the Axial Skeleton Imentioning

confidence: 99%

Recent research accomplishments on the International Space Station

Robinson

Rhatigan

Baumann

2005

2005 IEEE Aerospace Conference

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“…The absorptiometer was calibrated regularly as previously described. (17) The long-term precision of our measurement system in vitro is expressed by a coefficient of variation of 0.39%, and the short-term precision in vivo by 1.01%.…”

Section: Subjectsmentioning

confidence: 99%

“…Biochemical analyses of serum bone alkaline phosphatase (BAP), serum intact osteocalcin (BGP by enzyme-linked immunosorbent assay; Teijinn Co., Ltd., Tokyo, Japan), urinary pyridinolin, deoxypyridinolin (Pyr and DPyr by high performance liquid chromatography), hydroxyproline (HOP), and serum Ca and phosphorus were performed as previously described. (17) Bone mass measurement…”

Section: Subjectsmentioning

confidence: 99%

A Novel Polymorphism in the Promoter Region for the Human Osteocalcin Gene: The Possibility of a Correlation with Bone Mineral Density in Postmenopausal Japanese Women

Dohi

Iki

Ohgushi

et al. 1998

Journal of Bone and Mineral Research

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We present a polymorphism of the human osteocalcin gene (also known as BGP, for bone Gla protein) due to a 1 base pair (bp) substitution from cytosine to thymine at position 298 nucleotides (nt), which is at position 198 nt upstream from the BGP exon 1. This mutation was detected by single-strand conformation polymorphism analysis after polymerase chain reaction for the osteocalcin gene fragment (326 bp) and sequencing analysis. The cytosine/thymine polymorphism can be defined by restriction fragment length polymorphism analysis using a modified primer pair and the restriction endonuclease HindIII. The osteocalcin genotype was determined in 160 postmenopausal Japanese women (age 48 -80 years). Osteocalcin alleles were designated according to the absence (H) or presence (h) of the HindIII restriction site. There were 12 HH, 49 Hh, and 99 hh individuals, and the allele frequencies were 22.8% for H and 77.2% for h. To determine if genetic variation influences bone mineral density (BMD) and thus can be a determinant of susceptibility to osteoporosis in older women, we examined the association of BMD with the osteocalcin genotypes found in the present study. The subjects with genotype HH had the smallest BMD and those with hh had the greatest BMD among subjects, but these differences did not reach statistical significance. The HindIII genotype showed a significant effect on the prevalence of osteopenia in the subjects, that is, women with genotype HH had a 5.74 times greater risk for osteopenia (p < 0.05) and those with genotype Hh had a 1.59 times greater risk than women with genotype hh. We identified the osteocalcin gene polymorphism, detected with the HindIII genotype, which was suggested to influence bone density and is a possible genetic marker for bone metabolism. (J Bone Miner Res 1998;13:1633-1639)

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“…These include induced endothelial cell proliferation and capillary formation, which are integral to angiogenesis in the revascularization of healing bone fractures. 16 Hydroxyapatite [HAp; Ca 10 (PO4) 6 -(OH) 2 ] nanoparticles are chemically similar to the mineral component of bones and hard tissues in mammals. It is one of the few materials that are classified as bioactive, which means that it will support bone growth and osteointegration when used in orthopedics.…”

Section: Dovepressmentioning

confidence: 99%

“…which adapts to the new environment by shedding calcium 1 at a rate that is almost 10 times greater than that in a postmenopausal women 2,3 and loss of bone mineral density (BMD). [4][5][6] Microgravity changes the metabolic environment of bone leading to site-specific alterations in bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

Synergistic role of hydroxyapatite nanoparticles and pulsed electromagnetic field therapy to prevent bone loss in rats following exposure to simulated microgravity

Prakash

Behari²

2009

IJN

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Abstract:The purpose of the present study was to use capacitive coupling of pulsed electromagnetic field (CC-PEMF) and hydroxyapatite nanoparticles (HAp) as a countermeasure to prevent osteoporosis induced by simulated microgravity. We used the hind-limb suspension (HLS) rat model to simulate microgravity-induced bone losses for 45 days. In order to compare the resulting changes, mineralogical (bone mineral density [BMD], calcium [Ca], and phosphorus [P]), biochemical (osteocalcin, alkaline phosphatase [ALP], and type I collagen), and histological (scanning electron microscopy) parameters were adopted. As a countermeasure to the above, the effect of PEMF and HAp application were examined. Three-month-old female Wistar rats were randomly divided into control (n = 8), HLS (n = 8), HLS with PEMF (n = 8), HLS with HAp nanoparticles (n = 8), and HLS with HAp and PEMF (n = 8). We observed: 1) significant decrease (p  0.01) in BMD, Ca, P, type I collagen, and ALP activity in femur and tibia in hind-limb bone and serum osteocalcin in HLS rats as compared with the ground control. 2) Nonsignificant increase in BMD (p  0.1), Ca (p  0.1), P (p  0.5), type I collagen (p  0.1), and ALP activity (p  0.5) in femur and tibia in hind-limb bone and serum osteocalcin (p  0.5) in HLS + PEMF rats compared with HLS rats. 3) Significant increase in BMD (p  0.02), Ca (p  0.05), P (p  0.05), type I collagen (p  0.02), and ALP activity (p  0.02) in femur and tibia in hind-limb bone with a nonsignificant increase in serum osteocalcin (p  0.1) in HLS + HAp rats compared to HLS rats. 4) Significant increase in BMD (p  0.01). Ca (p  0.01). P (p  0.01). type I collagen (p  0.01). and ALP activity (p  0.01) in femur and tibia in hind-limb bone and serum osteocalcin (p  0.02) were also observed. Results suggest that a combination of low level PEMF and Hap nanoparticles has potential to control bone loss induced by simulated microgravity.

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Age, menopause, bone turnover markers and lumbar bone loss in healthy Japanese women

Cited by 48 publications

References 44 publications

Recent research accomplishments on the International Space Station

Recent research accomplishments on the International Space Station

A Novel Polymorphism in the Promoter Region for the Human Osteocalcin Gene: The Possibility of a Correlation with Bone Mineral Density in Postmenopausal Japanese Women

Synergistic role of hydroxyapatite nanoparticles and pulsed electromagnetic field therapy to prevent bone loss in rats following exposure to simulated microgravity

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