Age of onset of heaviest use of cannabis or alcohol in persons with severe opioid or cocaine use disorders

Butelman, Eduardo R.; Chen, Carina Y.; Brown, Kate; Lake, Kimberly J.; Kreek, Mary Jeanne

doi:10.1016/j.drugalcdep.2021.108834

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…[20][21][22][23][24] There is also an increased risk of SU disorders, psychiatric disorders and mortality with SU at a younger age. [25][26][27] Overcoming these barriers is key to improving life expectancy, HIV-related disabilities and quality of life. 28 29 Given the strong evidence for the influence of MH and SU on worsening HIV health outcomes, there is a clear need for increased access to and provision of MH and SU services.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

iVY: protocol for a randomised clinical trial to test the effect of a technology-based intervention to improve virological suppression among young adults with HIV in the USA

Saberi,

Stoner,

McCuistian

et al. 2023

BMJ Open

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IntroductionYoung adults with HIV (YWH) experience worse clinical outcomes than adults and have high rates of substance use (SU) and mental illness that impact their engagement in care and adherence to antiretroviral therapy (ART). The intervention for Virologic Suppression in Youth (iVY) aims to address treatment engagement/adherence, mental health (MH) and SU in a tailored manner using a differentiated care approach that is youth friendly. Findings will provide information about the impact of iVY on HIV virological suppression, MH and SU among YWH who are disproportionately impacted by HIV and at elevated risk for poor health outcomes.Methods and analysisThe iVY study will test the effect of a technology-based intervention with differing levels of resource requirements (ie, financial and personnel time) in a randomised clinical trial with an adaptive treatment strategy among 200 YWH (18–29 years old). The primary outcome is HIV virological suppression measured via dried blood spot. This piloted and protocolised intervention combines: (1) brief weekly sessions with a counsellor via a video-chat platform (video-counselling) to discuss MH, SU, HIV care engagement/adherence and other barriers to care; and (2) a mobile health app to address barriers such as ART forgetfulness, and social isolation. iVY has the potential to address important, distinct and changing barriers to HIV care engagement (eg, MH, SU) to increase virological suppression among YWH at elevated risk for poor health outcomes.Ethics and disseminationThis study and its protocols have been approved by the University of California, San Francisco Institutional Review Board. Study staff will work with a Youth Advisory Panel to disseminate results to YWH, participants and the academic community.Trial registration numberNCT05877729.

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