Age of Rats Seriously Affects the Degree of Retinal Damage Induced by Acute High Intraocular Pressure

Tan, Chang; Hu, Tu; Peng, Mingchao; Liu, Shuli; Tong, Jianbin; Ouyang, Wen; Le, Yuan

doi:10.3109/02713683.2014.922194

Cited by 13 publications

(15 citation statements)

References 40 publications

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“…Rejuvenation of aged BM by reconstitution with young Sca‐1 + cells reduced the functional deterioration following retinal injury. Pressure injury stimulates the release of neurotransmitters which contribute to apoptosis of neuronal cells and active BMSCs protect them from retinal apoptosis . These studies provide preliminary evidence for a new treatment strategy to mitigate the effects of increased intraocular pressure injury.…”

Section: Discussionmentioning

confidence: 76%

“…All of these responses contributed to the neuroprotective effects following increased intraocular pressure‐induced retinal ischaemic injury and improved healing of the injured retina. The retinal and optic nerve damage associated with I/R is markedly worse in older individuals . These investigations suggest that the loss of BM stem cell function with age could contribute to the impairment in retina repair and regeneration after injury.…”

Section: Discussionmentioning

confidence: 79%

“…In the current study, we investigated the effects of young BM- 20 These studies provide preliminary evidence for a new treatment strategy to mitigate the effects of increased intraocular pressure injury.…”

Section: Discussionmentioning

confidence: 99%

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Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Shao

et al. 2018

J Cellular Molecular Medi

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Retinal ganglion cell apoptosis and optic nerve degeneration are prevalent in aged patients, which may be related to the decrease in bone marrow (BM) stem cell number/function because of the possible cross‐talk between the two organs. This pathological process is accelerated by retinal ischaemia‐reperfusion (I/R) injury. This study investigated whether young BM stem cells can regenerate and repair the aged retina after acute I/R injury. Young BM stem cell antigen 1 positive (Sca‐1+) or Sca‐1− cells were transplanted into lethally irradiated aged recipient mice to generate Sca‐1+ and Sca‐1− chimaeras, respectively. The animals were housed for 3 months to allow the young Sca‐1 cells to repopulate in the BM of aged mice. Retinal I/R was then induced by elevation of intraocular pressure. Better preservation of visual function was found in Sca‐1+ than Sca‐1− chimaeras 7 days after injury. More Sca‐1+ cells homed to the retina than Sca‐1− cells and more cells differentiated into glial and microglial cells in the Sca‐1+ chimaeras. After injury, Sca‐1+ cells in the retina reduced host cellular apoptosis, which was associated with higher expression of fibroblast growth factor 2 (FGF2) in the Sca‐1+ chimaeras. Young Sca‐1+ cells repopulated the stem cells in the aged retina and diminished cellular apoptosis after acute I/R injury through FGF2 and Akt signalling pathways.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 79%

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Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Shao

et al. 2018

J Cellular Molecular Medi

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“…In line with this, an age‐related susceptibility of the rat retina to increased IOP has been demonstrated (Tan et al . ). Experimental glaucoma induced by CS provoked a progressive deficit in CTB transport from the retina to the LGN (which lies anterior to the SC, i.e., more proximal to the eye) that was also diminished at an early stage of glaucoma.…”

Section: Discussionmentioning

confidence: 97%

Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma

Bordone

Fleitas

Pasquini

et al. 2017

Journal of Neurochemistry

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Glaucoma is a leading cause of blindness, characterized by retinal ganglion cell (RGC) loss and optic nerve (ON) damage. Cumulative evidence suggests glial cell involvement in the degeneration of the ON and RGCs. We analyzed the contribution of microglial reactivity to early axoglial alterations of the ON in an induced model of ocular hypertension. For this purpose, vehicle or chondroitin sulfate (CS) were weekly injected into the eye anterior chamber from Wistar rats for different intervals. The amount of Brn3a(+) RGC significantly decreased in CS-injected eyes for 10 and 15 (but not 6) weeks. A reduction in anterograde transport of β-subunit cholera toxin was observed in the superior colliculus and the lateral geniculate nucleus contralateral to CS-injected eyes for 6 and 15 weeks. A disruption of cholera toxin β-subunit transport was observed at the proximal myelinated ON. A significant decrease in phosphorylated neurofilament heavy chain immunoreactivity, an increase in ionized calcium-binding adaptor molecule 1(+), ED1(+) (microglial markers), and glial fibrillary acidic protein (astrocytes) (+) area, and decreased luxol fast blue staining were observed in the ON at 6 and 15 weeks of ocular hypertension. Microglial reactivity involvement was examined through a daily treatment with minocycline (30 mg/kg, i.p.) for 2 weeks, after 4 weeks of ocular hypertension. Minocycline prevented the increase in ionized calcium-binding adaptor molecule 1(+), ED-1(+), and glial fibrillary acidic protein(+) area, the decrease in phosphorylated neurofilament heavy-chain immunoreactivity and luxol fast blue staining, and the deficit in anterograde transport induced by 6 weeks of ocular hypertension. Thus, targeting microglial reactivity might prevent early axoglial alterations in the glaucomatous ON. Cover Image for this issue: doi: 10.1111/jnc.13807.

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“…Alternatively, older patients may have a smaller neuronal reserve, allowing progressive changes to be detected earlier. 29 – 31 Myopic changes in older patients increase their vulnerability to glaucoma. Myopic changes are usually stable after aldolescence; however, they can impact glaucoma throughout life.…”

Section: Discussionmentioning

confidence: 99%

Impact of Age and Myopia on the Rate of Visual Field Progression in Glaucoma Patients

2016

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Myopia is rapidly increasing in young populations and patients with glaucoma associated with myopia are reported to be young aged in East Asia. These young patients have a longer life expectancy, which increases their risk of end-of-life visual disabilities. There is a need to understand the clinical course of myopic glaucoma patients, which may be important for the care of these myopic populations. In this study, we evaluated the relationship between the age at presentation and the rate of glaucoma progression in the visual field (VF) according to the presence of myopia. The study was conducted as a prospective observational study including 179 patients with open-angle glaucoma who had undergone at least 5 VF examinations with a follow-up of at least 5 years. The progression rate of the mean deviation (MD) and the pattern standard deviation (PSD) are expressed as change in decibels (dB) per year. The slopes of the MD and PSD were calculated by linear regression analyses. Factors related to the slope of VF MD changes were analyzed with correlation and regression analyses. The slope of the linear fit line plotted against age at presentation and the rate of change in the VF MD was −0.026 (P < 0.001) in the myopic group and −0.008 (P = 0.167) in the nonmyopic group; the relationship was more prominent in the myopic group than the nonmyopic group. In the myopic group, age (β = −0.417; 95% confidence intervals (CI), −0.651 to −0.200; P = 0.050) and baseline untreated intraocular pressure (β = −0.179; 95% CI, −0.331 to −0.028; P = 0.022) were significantly related to the rate of change in the MD, which was only the presence of disc hemorrhage (β = −0.335; 95% CI, −0.568 to −0.018; P = 0.022) in the nonmyopic group. Age at presentation was significantly related to the rate of change in the VF in glaucomatous eyes with myopia compared to eyes without myopia. Older age was significantly related to the rate of change in the VF only in myopic glaucomatous eyes.

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Age of Rats Seriously Affects the Degree of Retinal Damage Induced by Acute High Intraocular Pressure

Abstract: Our data suggest there exists an age-related susceptibility of rat retina to the increased IOP. Therefore, the effect of ages should be considered at glaucoma study of rat models.

Cited by 13 publications

References 40 publications

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2

Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma

Impact of Age and Myopia on the Rate of Visual Field Progression in Glaucoma Patients

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