Age patterns of immunoglobulins G, A & M in healthy children and the influence of breast feeding and vaccination status

Abstract

Serum levels of immunoglobulins G, A and M were determined by nephelometry in 414 infants and children aged 1 month to 14 years. The children were admitted to "Aghia Sophia" Teaching Hospital for Children for surgical corrections of minor anatomical abnormalities, but they were otherwise healthy. Statistical analysis was performed through multiple regression after logarithmic transformation of the immunoglobulin values. Immunoglobulin G (IgG) levels increased significantly by 18% per year until the age of 5 years and by 2% per year thereafter. Among children less than 5 years old, IgG levels tended to increase significantly with the number of doses of either DTP or Sabin vaccine. Immunoglobulin A (IgA) levels increased significantly by 27% until the age of 7 years and by 4% thereafter. Among children less than 7 years old, history of breast feeding was significantly associated with higher levels of IgA. Vaccination with either DTP or Sabin was associated with elevation of IgA levels among younger and, to a lesser extent, older children, but the elevations did not reach statistical significance. Immunoglobulin M (IgM) levels increased rapidly during the first 12 months of life and very slowly thereafter and they were significantly higher among girls. Among children less than one year old, there was evidence that vaccination with either DTP or Sabin was associated with elevated IgM levels, although the differences were not statistically significant possibly because of small numbers of infants in the study sample.(ABSTRACT TRUNCATED AT 250 WORDS)

Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects

“…The diagnosis of immunodeficiency was primarily based on reductions of serum IgG, IgG subclasses, IgA and/or IgM levels compared to age-matched controls. 10 Agammaglobulinemia was defined as a decrease of IgG level below 2.5 g/l. Special attention was drawn to frequency and type of infections, and laboratory results reflecting the immunological status.…”

Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants

“…In a secondary analysis, models were also adjusted for breastfeeding duration (months), since breastfeeding is associated with higher immunoglobulin A and E concentrations in the infant (Kanariou et al, 1995; Grandjean et al, 2010) as well as increased PCB concentrations in the infant. However, no noteworthy associations after adjustment for this potential confounder were observed.…”

Reference distributions for immunoglobulins A, G, and M: A comparison of a large cohort to the world's literature

“…Less than a third of these papers stratified their results by gender. Only nine (15,60,61,68,72,76,83,107,111) were included in the IgM analysis (Fig. 1C).…”

“…1C). In a separate analysis of reference range width (Figures 2A, 2B, 2C), 14 studies were available for comparison (15,17,46,56,60,68,76,83,85,90,91,94,107,111).…”