Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Chronic Pain

Boyd, Taylor; Chibueze, Joseph; Pester, Bethany D.; Saini, Rhea; Bar, Nir; Edwards, Robert R.; Adams, Meredith C.B.; Silver, Julie K.; Meints, Samantha M.; Burton-Murray, Helen

doi:10.1016/j.jpain.2024.03.007

The Journal of Pain

2024

DOI: 10.1016/j.jpain.2024.03.007

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Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Chronic Pain

Taylor Boyd,

Joseph Chibueze,

Bethany D. Pester

et al.

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Cited by 3 publications

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Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults

Langford,

Schneider,

Reeve

et al. 2024

Drugs Aging

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Approximately one in three older adults (aged 65 years and over) experience pain, negatively impacting their quality of life. Opioid analgesics are commonly prescribed to manage pain; however, balancing the benefits and harms of these high-risk analgesics can be challenging for both healthcare professionals and patients. This is particularly true for older adults, as factors such as polypharmacy, age-related physiological changes and cognitive decline may impact upon opioid safety and efficacy. Deprescribing is the patient-centred process of reducing or discontinuing a medication that is no longer appropriate, or where the risks of continuation are deemed to outweigh the anticipated benefits. Opioid deprescribing has been proposed as a mechanism to reduce individual and societal opioid-related harm; however, to date, research has predominantly focused on the general adult population, rather than older adults. This current opinion aims to summarise the existing opioid deprescribing literature, discussing its applicability for older adults. Drawing on a non-systematic review of the literature, it identifies unique challenges and considerations for this population, highlights international initiatives to enhance opioid deprescribing in clinical practice and proposes future directions to advance the field.

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Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults

Langford,

Schneider,

Reeve

et al. 2024

Drugs Aging

View full text Add to dashboard Cite

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Psychologically Informed Physical Therapy Management of Chronic Musculoskeletal Pain in Culturally Diverse Populations: An Intervention Logic Model

Monroe,

Archer,

Wegener

et al. 2025

The Journal of Pain

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Chronic Pain Management in an Aging Population: Current Challenges and Policy-Based Solutions

LaRowe,

Patidar,

Goetzinger

et al. 2024

Policy Insights from the Behavioral and Brain Sciences

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Chronic pain in older adults is highly prevalent and often more complex to manage. Despite some recent successes in improving chronic pain management in this population, critical challenges and policy barriers remain: (1) healthcare professionals do not have enough training, education or experience; (2) treatments are too focused on biological causes of pain; (3) opioid regulations have had unintended consequences; (4) there are barriers to nonopioid and non-drug chronic pain treatments; and (5) age-related stigma and discrimination make it more difficult to detect and treat chronic pain. To more effectively assess and manage chronic pain in older adults, a comprehensive, bipartisan approach must include: (1) teaching healthcare professionals about chronic pain in older adults; (2) assessing and addressing chronic pain through a biopsychosocial lens, (3) improving implementation of evidence-based clinical practice guidelines for opioid use, (4) increasing access to nonopioid and non-drug chronic pain treatments, and (5) strengthening programs to reduce ageism.

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Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Chronic Pain

Cited by 3 publications

References 38 publications

Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults

Minimising Harm and Managing Pain: Deprescribing Opioids in Older Adults

Psychologically Informed Physical Therapy Management of Chronic Musculoskeletal Pain in Culturally Diverse Populations: An Intervention Logic Model

Chronic Pain Management in an Aging Population: Current Challenges and Policy-Based Solutions

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