1981
DOI: 10.1016/0022-2828(81)90329-1
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Age-related alterations in cardiac protein turnover

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Cited by 30 publications
(8 citation statements)
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“…Cardiac Ks showed no age-related change in the dwarf mice, and very little change in the normal animals. The observations were made over a relatively short time-period, however, and a longer period may be required to observe decreases similar to those which occur in rats over a 1-to 2-year period (Crie, Millward, Bates et al 1981). The rise in KRNA in heart, as opposed to the fall in skeletal muscle, may reflect the fact that heart contains a large proportion of connective tissue cells (Grove, Nair & Zak, 1969) which could contain ribosomes which are relatively inactive.…”
Section: Millward Unpublished Results)mentioning
confidence: 94%
“…Cardiac Ks showed no age-related change in the dwarf mice, and very little change in the normal animals. The observations were made over a relatively short time-period, however, and a longer period may be required to observe decreases similar to those which occur in rats over a 1-to 2-year period (Crie, Millward, Bates et al 1981). The rise in KRNA in heart, as opposed to the fall in skeletal muscle, may reflect the fact that heart contains a large proportion of connective tissue cells (Grove, Nair & Zak, 1969) which could contain ribosomes which are relatively inactive.…”
Section: Millward Unpublished Results)mentioning
confidence: 94%
“…These results indicated that other individual proteins (e.g., contractile proteins, membrane proteins and additional extracellular proteins) were likely decreased. Based on previous measurements on collagen RNA and protein turnover rates during aging (Meerson et al 1978;Crie et al 1981), the increase in total collagen is likely a reflection of increased synthesis and/or decreased turnover rather than increased mRNA levels.…”
Section: Discussionmentioning
confidence: 94%
“…Semsei et a1 (343) Zs.-Nagy and Semsei (443) In vivo -50 Meerson et al (240) Nuclei -37 Liang et al (201) Haji et al (131) Nuclei -25 to -50 In vivo Increase in most tissues Kanungo et al (166) In vivo - 70 Tonna and Singh (396) Fibroblasts - 50 Chen et al (55) Again, one must be concerned with the accuracy in measuring RNA synthesis in the in vivo studies because the specific activities of the precursor pools were not measured. Figure 9.2 shows the effect of age on the synthesis of RNA by cultured fibroblasts isolated from the skin of human subjects over a wide spectrum of ages.…”
Section: Rna Synthesismentioning
confidence: 99%