Age‐related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging

Yabluchanskiy, Andriy; Nyúl‐Tóth, Ádám; Csiszár, Anna; Gulej, Rafał; Saunders, Debra; Towner, Rheal A.; Turner, Monroe P.; Zhao, Yuguang; Abdelkari, Dema; Tarantini, Stefano

doi:10.1111/psyp.13718

Cited by 32 publications

(37 citation statements)

References 263 publications

(268 reference statements)

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“…Therefore, our own hypothesis is that an individual's cognitive ability is better predicted by the neurovascular coupling ratio than by ΔCBF, ΔCMRO 2 , or BOLD alone (see Abdelkarim at al., 2019). Early results, showing highly demand‐dependent coupling in younger adults and demand‐independent coupling in older adults, are supportive of our hypotheses (see Yabluchanskiy et al., 2020).…”

Section: A General Model Of Neural Vascular and Cognitive Agingsupporting

confidence: 88%

The neural–vascular basis of age‐related processing speed decline

et al. 2021

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Most studies examining neurocognitive aging are based on the blood‐oxygen level‐dependent signal obtained during functional magnetic resonance imaging (fMRI). The physiological basis of this signal is neural–vascular coupling, the process by which neurons signal cerebrovasculature to dilate in response to an increase in active neural metabolism due to stimulation. These fMRI studies of aging rely on the hemodynamic equivalence assumption that this process is not disrupted by physiologic deterioration associated with aging. Studies of neural–vascular coupling challenge this assumption and show that neural–vascular coupling is closely related to cognition. In this review, we put forward a theory of processing speed decline in aging and how it is related to age‐related neural–vascular coupling changes based on the results of studies elucidating the relationships between cognition, cerebrovascular dynamics, and aging.

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Section: A General Model Of Neural Vascular and Cognitive Agingsupporting

confidence: 88%

The neural–vascular basis of age‐related processing speed decline

et al. 2021

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“…This result blurs the interpretation of age‐related BOLD signal changes, a measurement often used experimentally to theorize about the mechanisms of age‐related cognitive change. The varying vascular phenomena that may specifically contribute to BOLD signal changes are explicated in detail by Yabluchanskiy et al (2021)…”

Section: Methodological Considerations In Neurocognitive Aging Researchmentioning

confidence: 99%

“…The mechanisms controlling the vasomotility at the core of the vascular response are complex and multi‐faceted, and the role of changes in cerebrovascular reactivity in cognitive aging is a subject of intense study and debate, in part due to the profound implications for the interpretation of human neuroimaging in aging research (Abdelkarim et al., 2019). Mounting evidence points to a role for reduced cerebrovascular reactivity in age‐related cognitive decline (Abdelkarim et al., 2019; Fabiani, Gordon, et al., 2014; Hutchison et al., 2013; Tarantini et al., 2015; Tarantini, Yabluchanksiy, et al., 2017; Toth et al., 2017; Yabluchanskiy et al., 2021).…”

Section: How Does the Cerebrovasculature Affect Neural Function?mentioning

confidence: 99%

“…Clearly, the control of CVR is multi‐faceted and complex. This complexity has made it difficult to reach a clear consensus regarding how much CVR changes with age, a topic covered in depth by Yabluchanskiy et al (2021). Some age‐related changes induce more vasodilation, while others induce vasoconstriction, while still others disrupt signaling over space (Figure 4).…”

Section: How Does the Cerebrovasculature Change With Age?mentioning

confidence: 99%

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Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review

et al. 2021

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The process of aging includes changes in cellular biology that affect local interactions between cells and their environments and eventually propagate to systemic levels. In the brain, where neurons critically depend on an efficient and dynamic supply of oxygen and glucose, age‐related changes in the complex interaction between the brain parenchyma and the cerebrovasculature have effects on health and functioning that negatively impact cognition and play a role in pathology. Thus, cerebrovascular health is considered one of the main mechanisms by which a healthy lifestyle, such as habitual cardiorespiratory exercise and a healthful diet, could lead to improved cognitive outcomes with aging. This review aims at detailing how the physiology of the cerebral vascular system changes with age and how these changes lead to differential trajectories of cognitive maintenance or decline. This provides a framework for generating specific mechanistic hypotheses about the efficacy of proposed interventions and lifestyle covariates that contribute to enhanced cognitive well‐being. Finally, we discuss the methodological implications of age‐related changes in the cerebral vasculature for human cognitive neuroscience research and propose directions for future experiments aimed at investigating age‐related changes in the relationship between physiology and cognitive mechanisms.

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“…The second part of this special issue focuses on how age‐related changes in the cerebral vasculature and neurovascular unit can manifest as alterations in cerebrovascular reactivity and neurovascular coupling. It opens with a comprehensive review of neurovascular coupling by Yabluchanskiy and colleagues (2021). Focusing on animal research, these authors review the effects of age‐related pathophysiological phenomena on the integrity of the microvasculature, and on microcirculation, which lead to changes in reactivity and coupling.…”

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confidence: 99%