Age-related alterations in the lacrimal gland of adult albino rat: A light and electron microscopic study

El-Fadaly, Amina B.; El-Shaarawy, Ehab Aa; Rizk, A.; Nasralla, Mogeda M.; Shuaib, Doaa

doi:10.1016/j.aanat.2014.06.005

Cited by 26 publications

(30 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In senile rats, numerous lipid droplets are located in the cytoplasm of the LG acini (EL-FADALY et al 2014), as in the European bison. Also MARTIN et al (1988) observed lipid droplets in the canine LG.…”

Section: Discussionmentioning

confidence: 99%

“…The mucoserous granules have a dense core embedded in matrix, which was previously described by GARGIULO et al (1999). EL-FADALY et al (2014) & ALDANA MARCOS et al (2002 demonstrated the presence of electron-dense and moderately electron-dense secretory granules in acinar cells of the LG. The nuclei of these cells have a widely dispersed chromatin and prominent nucleoli.…”

Section: Discussionmentioning

confidence: 99%

“…For histomorphometric study of capsule thickness, diameters of alveoli, acini and tubules and interlobares septa thickness, the method described by EL-FADALY et al (2014) was used. Measurement was performed on the HG, LG and SGTE.…”

Section: Histomorphometric Study In Hande Stained Sectionsmentioning

confidence: 99%

See 2 more Smart Citations

Histology, histochemistry and fine structure of the Harderian gland, lacrimal gland and superficial gland of the third eyelid of the European bison, Bison bonasus bonasus (Artiodactyla: Bovidae)

Klećkowska‐Nawrot¹,

Nowaczyk²,

Goździewska‐Harłajczuk³

et al. 2015

Zoologia (Curitiba)

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histology, histochemistry and fine structure of the Harderian gland, lacrimal gland and superficial gland of the third eyelid of the European bison, Bison bonasus bonasus (Artiodactyla: Bovidae)

Klećkowska‐Nawrot¹,

Nowaczyk²,

Goździewska‐Harłajczuk³

et al. 2015

Zoologia (Curitiba)

View full text Add to dashboard Cite

“…In a rat model, the lacrimal glands of older animals revealed acinar, stromal, and ductal changes on light microscopy (e.g. acini: degeneration, decreased density, nuclear changes, lipofuscin-like inclusions; stroma: increased collagen, ducts; dilation) [12]. Interestingly, these changes were more prominent in older female rats compared to males [12].…”

Section: Dry Eye and Agingmentioning

confidence: 99%

“…acini: degeneration, decreased density, nuclear changes, lipofuscin-like inclusions; stroma: increased collagen, ducts; dilation) [12]. Interestingly, these changes were more prominent in older female rats compared to males [12]. Older lacrimal glands were also found to synthesize less protein and secrete less fluid after stimulation with substance P, vasoactive intestinal peptide and 5-hydroxytryptamine [15].…”

Section: Dry Eye and Agingmentioning

confidence: 99%

Therapeutic Strategies to Treat Dry Eye in an Aging Population

Ezuddin

Alawa

2015

Drugs Aging

View full text Add to dashboard Cite

Dry eye (DE) is a prevalent ocular disease that primarily affects the elderly. Affecting up to 30% of adults aged 50 years and older, dry eye affects both visual function and quality of life. Symptoms of dry eye which include ocular pain (aching, burning), visual disturbances, and tearing can be addressed with therapeutic agents that target dysfunction of the meibomian glands, lacrimal glands, goblet cells, ocular surface and/or neural network. This review provides an overview of the efficacy, use, and limitations of current therapeutic interventions being used to treat DE.

show abstract

Does Menopausal Status Affect Dry Eye Disease Treatment Outcomes with OC-01 (Varenicline Solution) Nasal Spray? A Post Hoc Analysis of ONSET-1 and ONSET-2 Clinical Trials

Nijm

Zhu

Hemphill³

et al. 2022

Ophthalmol Ther

View full text Add to dashboard Cite

Introduction This study sought to compare the efficacy of OC-01 (varenicline solution) nasal spray for treatment of dry eye disease (DED) in postmenopausal women (PM+) versus women who were not postmenopausal (PM−). Methods This was a post hoc subgroup analysis of data integrated from two prior randomized controlled clinical trials, ONSET-1 and ONSET-2. Women randomized to treatment with OC-01 (varenicline solution) nasal spray 0.03 mg or vehicle control (VC) whose self-reported menopausal status (PM+ versus PM−) was known were included. Outcomes included the treatment difference (the OC-01 [varenicline solution] nasal spray change from baseline [CFB] minus VC CFB) in Schirmer test score (STS, mm) with anesthesia and the eye dryness score (EDS) measured on a 100-mm visual analog scale (0 = no discomfort, 100 = maximal discomfort). Least-squares mean treatment differences were derived from analysis of covariance (ANCOVA) models. Results Overall, 449 female participants in the ONSET-1 and ONSET-2 trials randomized to the OC-01 (varenicline solution) nasal spray 0.03 mg or VC groups were included in this analysis. The treatment–menopausal status interaction terms in the STS and EDS ANCOVA and logistic regression models were not statistically significant ( p > 0.05), indicating consistency of treatment effect between the PM− and PM+ groups. The treatment difference in STS was similar in the PM− and PM+ groups (6.7 and 5.5 mm, respectively). The treatment difference in EDS was similar in the PM− and PM+ groups (− 5.5 and − 4.1, respectively). Conclusions OC-01 (varenicline solution) nasal spray demonstrated similar efficacy in promoting natural tear production and improving symptoms in both PM− and PM+ groups. As menopausal-related hormonal changes may be associated with more severe DED, these results may support OC-01 (varenicline solution) nasal spray as an effective treatment for DED in women regardless of presenting menopausal status. Trial Registration Post hoc subgroup analysis of data integrated from ONSET-1 (ClinicalTrials.gov identifier NCT03636061) and ONSET-2 (ClinicalTrials.gov identifier NCT04036292).

show abstract

Age-related alterations in the lacrimal gland of adult albino rat: A light and electron microscopic study

Cited by 26 publications

References 23 publications

Histology, histochemistry and fine structure of the Harderian gland, lacrimal gland and superficial gland of the third eyelid of the European bison, Bison bonasus bonasus (Artiodactyla: Bovidae)

Histology, histochemistry and fine structure of the Harderian gland, lacrimal gland and superficial gland of the third eyelid of the European bison, Bison bonasus bonasus (Artiodactyla: Bovidae)

Therapeutic Strategies to Treat Dry Eye in an Aging Population

Does Menopausal Status Affect Dry Eye Disease Treatment Outcomes with OC-01 (Varenicline Solution) Nasal Spray? A Post Hoc Analysis of ONSET-1 and ONSET-2 Clinical Trials

Contact Info

Product

Resources

About