Age‐related antinuclear factors: Immunologic characteristics and associated clinical aspects

Svec, Kathryn H.; Veit, Bruce C.

doi:10.1002/art.1780100604

Cited by 52 publications

(15 citation statements)

References 23 publications

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“…Such an association has been reported by Moskowitz and Katz (7), but in their patients, the predominant symptomatology was related to the basic rheumatoid disease rather than to the chondrocalcinosis. The presence of a transiently positive antinuclear factor in our patient lends some support to the possibility of underlying connective tissue disease; however, it is known that up to 207& of healthy women over the age of 60 may have positive tests for antinuclear factor (8). The cystic erosions as seen in the wrists and shoulders, while suggestive of rheumatoid arthritis, have also been reported to occur in both idiopathic chondrocalcinosis and chondrocalcinosis associated with hemochromatosis (9).…”

Section: Electron Microscopy and Electron Diffraction Studiessupporting

confidence: 60%

Chronic Synovitis as a Manifestation of Calcium Crystal Deposition Disease

Moskowitz

Harris

Schwartz

et al. 1971

Arthritis & Rheumatism

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A 67-year-old woman had an 8jear history of chronic polyarthritis associated with extensive chondrocalcinosis. Synovial biopsy on two occasions showed crystalline material in the synovium, associated with chronic granulomatous reaction. Polarizing microscopy studies suggested the presetnce of both calcium pyrophosphate dihydrate and dicalcium phosphate dihydrate crystals. Electron diffraction studies were also consistent with the presence of a mixed crystal population. The chronic arthritis seen appears to be the result of chronic synovial inflammation induced by calcium crystal deposits.

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Section: Electron Microscopy and Electron Diffraction Studiessupporting

confidence: 60%

Chronic Synovitis as a Manifestation of Calcium Crystal Deposition Disease

Moskowitz

Harris

Schwartz

et al. 1971

Arthritis & Rheumatism

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“…The incidence of IgG, IgM, and IgA * ANF in OA sera correspond closely to that of age and sex matched controls. Earlier data indicate that ANF -* occurs with increasing frequency in older persons, 64 >64 expecially women (Svec and Veit, 1967;Willkens, Whitaker, Anderson, and Berven, 1967). Accorpolymorphonu-dingly the rather high prevalence of ANF in the kG GS-ANF in controls and the OA patients can probably be asfindings in one cribed to their age and sex.…”

Section: Resultsmentioning

confidence: 87%

Granulocyte-specific antinuclear factors in synovial fluids and sera from patients with rheumatoid arthritis.

Wiik¹,

Jensen²,

Friis³

1974

Annals of the Rheumatic Diseases

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The prevalence of antinuclear factors (ANF) found in sera and synovial fluids (SF) of patients with rheumatoid arthritis (RA) varies from one study to another, chiefly according to the technique used. The importance of sensitivity has been emphasized by Ritchie who found ANF in 89 % of undiluted RA sera, employing rat liver as nuclear substrate and an antihuman immunoglobulin conjugate detecting the three main classes of immunoglobulins (Ig) (Ritchie, 1967). As 61 % of normal control sera contained low titres of ANF (<16) a titre of 16 was selected as the upper normal limit. Titres above 16 were found in 32 % of the RA sera.

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“…An increased occurrence of such factors with advancing age has been noted as well (7). Unfortunately, despite the reliance often placed on the fluorescent antinuclear antibody test, statistical analysis has demonstrated that a correct interpretation of this test often depends upon the overall clinical picture of each patient (8).…”

Section: Brief Report Secondary Syphilis Mimicking Systemic Lupus Erymentioning

confidence: 99%

Secondary syphilis mimicking systemic lupus erythematosus

Skillrud

Bunch

1983

Arthritis & Rheumatism

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The broad spectrum of clinical manifestations seen in certain infectious diseases often mimics the protean aspects of chronic inflammatory disorders. The frequent lack of specific clinical and laboratory features of a rheumatic disease, such as systemic lupus erythematosus (SLE), may cause confusion in the diagnostic process. We describe a patient who has secondary syphilis and shows signs and symptoms compatible with SLE.Case report. A 36-year-old white man presented with complaints of fevers and arthralgias of 2 months' duration. He noted a sore throat, low-grade fever, and low backache at the onset of symptoms. His private physician performed a throat culture the results of which were negative for P-streptococcus, and aspirin was prescribed.Over the intervening 2 months, the patient noted persistent diffuse arthralgias which were maximal in the wrists and knees and accompanied by morning stiffness. Intermittent fever to 39°C ensued. Small scales developed on the scalp, followed by patchy hair loss. Several small circular breaks in the skin were noted, as were two sores on the inner lower lip and gum. He reconsulted his private physician who performed laboratory tests that showed erythrocyte sedimentation rate (ESR) > 100 mm/hour and antinu- clear antibodies positive at 1 :80. A diagnosis of systemic lupus erythematosus was made, and conservative therapy with salicylates was begun.Because of his subsequent failure to improve while on this regimen, the patient was referred to Mayo Clinic by his local physician for consideration of additional treatment. Review of his history revealed an episode of hepatitis with jaundice. There was no history of pleurisy, photosensitivity, or Raynaud's phenomenon. Sexual preference was homosexual with several partners. He denied having previous genital lesions or known venereal disease.At the time of physical examination he was afebrile. Patchy hair loss was seen on the scalp ( Figure 1) along with alopecia of the pubis. Small ulcers were noted inside the lips. Scattered cervical, postauricular, and inguinal nodes were palpable. No active synovitis or splenomegaly was evident, and genital examination was unremarkable.Blood tests revealed hemoglobin of 10.8 gm/dl (mean cell volume 88.0p3), white blood cell count of 4,3OO/pl, and ESR 108 mm/hour. A peripheral smear showed mild aniswytosis and rouleaux formation. Serum protein electrophoresis included a gamma globulin count of 2.33 gm/dl. A blood chemistry profile, complement studies, fluorescent antinuclear antibody, anti-native DNA antibody, and test for rheumatoid factor were negative or normal. However, the hepatitis B surface antigen test was positive, and the syphilis serology test using the ART system (Technicon Instrument Corp., Tarrytown, NY) was reactive at 1:64 dilution.The diagnosis of syphilis was suspected, and a fluorescent treponemal antibody absorption (FTA-ABS) test for syphilis was 4 + reactive. Oral, rectal,

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Age‐related antinuclear factors: Immunologic characteristics and associated clinical aspects

Cited by 52 publications

References 23 publications

Chronic Synovitis as a Manifestation of Calcium Crystal Deposition Disease

Chronic Synovitis as a Manifestation of Calcium Crystal Deposition Disease

Granulocyte-specific antinuclear factors in synovial fluids and sera from patients with rheumatoid arthritis.

Secondary syphilis mimicking systemic lupus erythematosus

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