Age-Related Association of Calcitonin with Parameters of Anthropometry, Bone and Calcium Metabolism during Childhood

Sonntag, Juliane; Vogel, Mandy; Geserick, Mandy; Eckelt, Felix; Körner, Antje; Raue, Friedhelm; Kieß, Wieland; Kratzsch, Jürgen

doi:10.1159/000512107

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…In this study, serum calcium levels tended to be stable and there was no significant correlation with 25(OH)D levels, which was consistent with most survey results. 31 Considering that human serum calcium levels play an important role in the body, such as in the activity of nerves and muscles, blood calcium should be maintained at a stable concentration. Although serum calcium is positively correlated with bone mineral density, it does not directly reflect calcium deficiency and bone abnormality.…”

Section: Discussionmentioning

confidence: 99%

Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

Che

Guo

et al. 2022

J Int Med Res

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Objective Research is limited regarding biochemical markers of bone metabolism among children with cow’s milk protein allergy (CMPA). We aimed to determine differences in vitamin D and bone metabolism markers between infants with CMPA and healthy infants and explore relationships between these in a cross-sectional study. Methods In total, we included 41 children diagnosed with CMPA and under systematic medical and nutritional care at our center, and 50 healthy children as a control group. We reviewed demographic and clinical characteristics and measured serum biomarkers. Results We found that serum 25-hydroxyvitamin D (25(OH)D) levels among infants in the CMPA group were significantly lower than those in the control group, and levels of bone-specific alkaline phosphatase (BALP), serum phosphorus, and serum calcitonin were reduced. Pearson correlation analysis showed that serum 25(OH)D concentrations in the CMPA group were negatively correlated with parathyroid hormone but not significantly correlated with calcitonin and BALP. Logistic regression showed that CMPA was a risk factor for vitamin D deficiency. Conclusions Our study indicated that CMPA was associated with disturbances in bone metabolism. Levels of vitamin D in children with CMPA were lower than those in healthy children. CMPA was a risk factor for vitamin D deficiency.

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Section: Discussionmentioning

confidence: 99%

Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

Che

Guo

et al. 2022

J Int Med Res

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“…In summary, the blood vessels in the thyroid play a vital role in supporting the thyroid gland's function, ensuring the proper distribution and production of thyroid hormones. To a lesser extent, the parafollicular C cells produce calcitonin, which, together with the parathyroid hormone produced in the parathyroid, acts on calcium metabolism [30][31][32]. The main functional part of this gland is the thyroid follicle, which is widely distributed along the thyroid and is supported by loose connective tissue.…”

Section: Thyroid Morphophysiology: An Overviewmentioning

confidence: 99%

Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic–Pituitary–Thyroid Axis

Azeredo,

de Sousa Anselmo,

Soares

et al. 2023

IJMS

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Parabens are classified as endocrine-disrupting chemicals (EDCs) capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (THs), which is controlled by the hypothalamic–pituitary–thyroid axis (HPT). Given the crucial role of these hormones in health and the growing evidence of diseases related to thyroid dysfunction, this review looks at the effects of paraben exposure on the thyroid. In this study, we considered research carried out in vitro and in vivo and epidemiological studies published between 1951 and 2023, which demonstrated an association between exposure to parabens and dysfunctions of the HPT axis. In humans, exposure to parabens increases thyroid-stimulating hormone (TSH) levels, while exposure decreases TSH levels in rodents. The effects on THs levels are also poorly described, as well as peripheral metabolism. Regardless, recent studies have shown different actions between different subtypes of parabens on the HPT axis, which allows us to speculate that the mechanism of action of these parabens is different. Furthermore, studies of exposure to parabens are more evident in women than in men. Therefore, future studies are needed to clarify the effects of exposure to parabens and their mechanisms of action on this axis.

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“…The thyroid tissue is composed of several follicles and a large amount of blood vessels, responsible for the distribution of hormones to the body. To a lesser extent, the parafollicular C cells produce calcitonin, which, together with the parathyroid hormone produced in the parathyroid, acts on calcium metabolism 30,31,32 . The main functional part of this gland is the thyroid follicle, which is widely distributed along the thyroid and is supported by loose connective tissue.…”

Section: Thyroid Morphophysiology: An Overviewmentioning

confidence: 99%

Environmental Endocrinology: Parabens Hazardous Effects on HPT Axis

Azeredo,

Anselmo,

Soares

et al. 2023

Preprint

View full text Add to dashboard Cite

Parabens are classified as endocrine disrupting compounds (EDCs), capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (TH) which is controlled by hypothalamic-pituitary-thyroid axis (HPT). Given the crucial role of these hormones in health and the growing evidence of diseases related to thyroid dysfunction, this review looks at the effects of paraben exposure on the thyroid. In this study, we considered research carried out in vitro, in vivo, and epidemiological studies published between 1951 and 2023, which demonstrated an association between exposure to parabens and dysfunctions of the HPT axis. In humans, exposure to parabens appears to increase thyroid-stimulating hormone (TSH) levels, while in rodents, exposure decreases TSH levels. The effects on HT levels are also poorly described, as well as peripheral metabolism. Regardless, recent studies have shown different actions between different subtypes of parabens on the HPT axis, which allows us to speculate that the mechanism of action of these parabens is different. Furthermore, studies of exposure to parabens are more evident in women than in men. Therefore, future studies are needed to clarify the effects of exposure to parabens and their mechanisms of action on this axis.

show abstract

Age-Related Association of Calcitonin with Parameters of Anthropometry, Bone and Calcium Metabolism during Childhood

Cited by 5 publications

References 48 publications

Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

Correlation between vitamin D levels and bone metabolism in children with cow’s milk allergy

Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic–Pituitary–Thyroid Axis

Environmental Endocrinology: Parabens Hazardous Effects on HPT Axis

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