Age-related auditory pathology in the CBA/J mouse

Sha, Su Hua; Kanicki, Ariane; Dootz, Gary A.; Talaska, Andra E.; Hälsey, Karin; Dolan, David F.; Altschuler, Richard A.; Schacht, Jochen

doi:10.1016/j.heares.2008.06.001

Cited by 105 publications

(107 citation statements)

References 30 publications

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“…ABR and DPOAE findings here are consistent with reports of progressive age-related decreases in both inner and outer hair cell densities (Spongr et al 1997), loss of spiral ganglion fibers (Ohlemiller and Gagnon 2004), and confirm and extend previous studies of age related changes in auditory function reported for the CBA/CaJ mouse strain (Guimaraes et al 2004;Henry 2004;Sha et al 2008).…”

Section: Discussionsupporting

confidence: 91%

“…The EP is inherently difficult to measure and varies by measurement site, species, and genetic strain. For example, in gerbils and BALB/cJ mice, the EP has been shown to decline as a function of age (Gratton et al 1996), whereas the C57BL/6 J and CBA/CaJ mouse strains show no change or limited change in the EP (Lang et al 2002;Ohlemiller et al 2006;Wu and Marcus 2003;Sha et al 2008). The finding that the EP does not decrease with age in the CBA/CaJ strain makes it unlikely that this is the underlying basis for the decreased cochlear sensitivities seen here with aging.…”

Section: Discussionmentioning

confidence: 99%

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Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Mock

Jones

2010

JARO

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The CBA/CaJ mouse strain is commonly used as a control as it has no known genetic mutations affecting the inner ear, maintains hearing sensitivity throughout life, and serves as a background for creating new genetic strains. The purpose of the present study was to characterize the effects of age and gender on gravity receptor function and compare functional changes between auditory and vestibular modalities. Vestibular-evoked potentials (VsEPs), auditory brainstem responses (ABRs), and distortion product otoacoustic emissions were measured in 131 mice. VsEP thresholds deteriorated an average of 0.39 dB re: 1.0 g/ms per month and at the oldest ages (18-23 months old) showed an average loss of 49% of VsEP dynamic range. No significant gender differences were found for VsEPs. ABR thresholds increased by an average of 1.35, 1.38, and 1.15 dB pe SPL per month for ABR stimulus frequencies of 8, 16, and 32 kHz, respectively, demonstrating an average decrease in auditory dynamic range of 25-35% at advanced ages. Both modalities declined with age. Age-related decreases in gravity receptor sensitivity should be considered when using the CBA/CaJ strain for vestibular studies.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Mock

Jones

2010

JARO

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“…Because the Cdh23 753A mutation is known to promote early onset of AHL in C57BL/6J mice (4-6, 8, 9), it is possible that hair cells in mice carrying the Cdh23 753A mutation are more susceptible to oxidative stress and apoptosis, thereby limiting the general implication of our findings. However, the C57BL/6J strain displays the classic pattern of AHL (4, 5, 7), similar to that reported in humans (1,38) and in the CBA/J mouse strain that does not possess the Cdh23 753A mutation and displays late onset of AHL by 18 months of age (4,7,39). In both strains, the onset of AHL begins in the high-frequency region and spreads toward the low frequencies with age, and the loss of hair cells and neurons begins in the base and spreads toward the apex of the cochlea with age (4,5,7,39).…”

Section: Discussionsupporting

confidence: 80%

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

Someya

Kondo

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

290

304

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Age-related hearing loss (AHL), known as presbycusis, is a universal feature of mammalian aging and is the most common sensory disorder in the elderly population. The molecular mechanisms underlying AHL are unknown, and currently there is no treatment for the disorder. Here we report that C57BL/6J mice with a deletion of the mitochondrial pro-apoptotic gene Bak exhibit reduced age-related apoptotic cell death of spiral ganglion neurons and hair cells in the cochlea, and prevention of AHL. Oxidative stress induces Bak expression in primary cochlear cells, and Bak deficiency prevents apoptotic cell death. Furthermore, a mitochondrially targeted catalase transgene suppresses Bak expression in the cochlea, reduces cochlear cell death, and prevents AHL. Oral supplementation with the mitochondrial antioxidants ␣-lipoic acid and coenzyme Q 10 also suppresses Bak expression in the cochlea, reduces cochlear cell death, and prevents AHL. Thus, induction of a Bak-dependent mitochondrial apoptosis program in response to oxidative stress is a key mechanism of AHL in C57BL/6J mice.aging ͉ antioxidant ͉ cochlea ͉ oxidative stress ͉ presbycusis A ge-related hearing loss (AHL), also known as presbycusis, is characterized by an age-dependent decline of auditory function associated with loss of sensory hair cells, spiral ganglion (SG) neurons, and stria vascularis cells in the cochlea of the inner ear (1, 2). Hair cells and SG neurons do not regenerate in mammals, and loss of these long-lived cochlear cells leads to permanent hearing impairment. AHL affects more than 40% of people greater than 65 years of age in the United States (1, 2) and is projected to afflict more than 28 million Americans by 2030 (1, 3

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“…7,8 This is similar to presbyacusis, that affects higher frequencies first. 9,10 Sensory hair cell loss and cochlea neuron loss at the basal turns are thought to be responsible for presbyacusis. 11 Nakae et al made similar observations in an animal model of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors influencing sensorineural hearing loss among type II diabetes mellitus patients

2018

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Background: The typical hearing loss described among diabetes patients is progressive, bilateral, sensorineural deafness of gradual onset that predominantly affects the higher frequencies. Although there is mounting evidence for a relationship between diabetes and hearing impairment the awareness of auditory organ involvement in the course of diabetes is still not widespread among healthcare providers involved in diabetes care. Objective of present study was to assess the prevalence and the factors influencing sensorineural deafness among the patients with type II diabetes mellitus.Methods: A cross-sectional study was conducted at our hospital for a period of 6 months. All type II diabetes patients without any other major systemic illness (CVA, coronary artery disease, thyroid disorders) were included for the study. A total of 300 patients were included in our study and the informed consent was obtained from all the study participants. A detailed history related to hearing loss and diabetes status was elicited from all the patients. All basic blood investigations along with HbA1c was performed on all the patients. All the patients were subjected to pure tone audiometry and it was performed using a pure tone audiometer model AUL 12096 audiometer of Labat company in a sound proof room.Results: The total prevalence of sensori-neural deafness among the study subjects was found to be 51.3% with majority of them having mild to moderate degree of sensori-neural deafness. Increase in age, female gender, longer duration of diabetes and higher HbA1C levels are the factors which had influenced the state of sensorineural deafness among the study subjects.Conclusions: The use of audiological test at primary care level should be made mandate for screening all the diabetes patients for hearing loss such a way the quality of life can be improved for patients requiring therapeutic interventions for their hearing improvement.

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Age-related auditory pathology in the CBA/J mouse

Cited by 105 publications

References 30 publications

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis

Prevalence and factors influencing sensorineural hearing loss among type II diabetes mellitus patients

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