Age‐related change and sex difference over 60s in disc‐fovea angle in Japanese population: the Nagahama Study

Miyata, Manabu; Yoshikawa, Munemitsu; Ohtsuki, Hiroshi; Muraoka, Yuki; Hata, Masaharu; Yokota, Satoshi; Fujimoto, Masahiro; Miyake, Masahiro; Tabara, Yasuharu; Matsuda, Fumihiko; Yoshimura, Nagahisa

doi:10.1111/aos.13642

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…This nding is consistent with the earlier studies that reported that the population is greater in excyclodeviation than incyclodeviation. 3,7,32 Therefore, we consider that it may better to apply our model only to the excyclodeviation until enough subjects with incyclodeviation are accumulated. Our model can detect between excyclodeviation and incyclodeviation from the plus and minus signs calculated from the difference between the fovea and ONH.…”

Section: Discussionmentioning

confidence: 99%

Automatic Estimation of Objective Cyclodeviation in Fundus Image Using Machine Learning

Hirota

Fukushima

Sasaki

et al. 2022

Preprint

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Calculating the angle of objective cyclodeviation has been based on the difference between the fovea and center of the optic nerve head (ONH) in fundus images. An examiner defines the location of the fovea and center of ONH manually; thus, there is an influence of bias, and the analysis time per fundus image is long. Therefore, in this study, we developed a machine learning-based model for automatic cyclodeviation estimation using fundus images. Our model is divided into two steps: detecting macular and ONH regions using the single shot multibox detector (SSD) and estimating cyclodeviaiton using gradient boosting on decision trees of CatBoost. The SSD detected the macular and ONH with a 75% average precision of 99.7% and 99.4%. Then, CatBoost estimated the objective manual cyclodeviation with a mean absolute error of 0.804. These findings suggest that the machine learning-based algorithm estimate cyclodeviation with the same accuracy as a human from fundus images.

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Section: Discussionmentioning

confidence: 99%

Automatic Estimation of Objective Cyclodeviation in Fundus Image Using Machine Learning

Hirota

Fukushima

Sasaki

et al. 2022

Preprint

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“…First, the study was only performed in participants aged around 20 years. Miyata et al 16 evaluated the age-related changes in DFA in the Nagahama study and reported that older people had larger DFA than younger people and tended to exhibit exocyclic rotation according to age. Further studies are warranted among participants with various ages and glaucoma patients to examine the incidence of cyclodeviation.…”

Section: Discussionmentioning

confidence: 99%

“…Several methods have been used for measuring the objective cyclodeviation including artificial markers such as physical markers, corneal tattoo, scleral markings, 6 7 search coil, 8 tracking system on an excimer laser, 9 the iris pattern imaging 10 and fundus imaging. [11][12][13][14][15][16][17][18][19] In this study, we used fundus photography to reproduce the conditions similar to that during OCT. Thereby, we aimed to assess the differences and variations in the angle of cyclodeviation under binocular opening situation and monocular occlusion.…”

Section: Open Accessmentioning

confidence: 99%

“…In this study, we did not measure the absolute angle because we focused only on the changes in the angle of cyclodeviation under the two conditions. Therefore, we did not measure the disc-foveal angle, [14][15][16][17][18][19] which required identification of the centre of the optic disc. Instead, the narrowest and clearest vessels on the optic disc margin were selected for each participant, and a straight line was drawn at the intersection (triangle) and fovea (asterisk) between the vessel and papillary limbus.…”

Section: Data Processingmentioning

confidence: 99%

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Assessment of objective ocular cyclodeviation under monocular condition and binocular condition using fundus photography

et al. 2020

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ObjectiveThe relationship between retinal structure and function of glaucomatous eyes has attracted a great deal of research attention. However, visual field tests are conducted under monocular condition, and ophthalmic imaging was performed in patients without occlusion. We aimed to assess the objective ocular cyclodeviation between monocular occlusion and binocular conditions using fundus photography.Methods and analysisThis study included 76 healthy participants. We obtained six photos of the right eye of each patient using fundus photography. Three of the photographs were taken under monocular conditions, and the other three, under binocular conditions. We measured the optic disc margin-fovea angle (MFA) of the line connecting one point of the disc limbus and the fovea. One-way repeated analysis of variance was used to compare the angles under both conditions. We also examined the direction of ocular rotation under the binocular condition regarding the monocular condition.ResultsThe MFAs were 12.12°±3.83° and 12.19°±3.95° under the monocular and binocular conditions, respectively. There was no significant difference in both MFAs (F=1.19, p=0.28). The mean cyclodeviation was 0.07°±0.80° (range: −2.40° to +2.75°). A total of 38 eyes showed excycloduction, while another 38 showed incycloduction.ConclusionSignificant cyclodeviation did not occur regardless of the existence of an occlusion. When examining the relationship between retinal structure and function, the difference in rotation angle under both conditions need not be taken into consideration if the other disease did not cause pathological cyclodeviation.

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“…The inter-eye difference of the fovea–to-disc angle in normal subjects was observed previously in a range of 0.0° to 4.4° based on fundus photographs by Bixenman and von Noorden [ 20 ], and more recently as a mean of 1.15° ± 1.39° by Jethani et al [ 22 ]. The fovea-to-disc angle followed a normal distribution in a population-based study [ 23 ]. Therefore, we used a range covering approximately 95% of the data which falls within two standard deviations of the mean of normal subjects reported by Jethani et al as a reference value (3.93°) for determining whether the fundus excyclotorsion was symmetric or asymmetric.…”

Section: Methodsmentioning

confidence: 99%

Bilateral Fundus Excyclotorsion in Unilateral Superior Oblique Palsy Confirmed by MR Imaging

Hong

Yang

Kim

et al. 2020

JCM

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Purpose: To determine whether bilateral fundus excyclotorsion is helpful in distinguishing bilateral superior oblique palsy (SOP) from unilateral SOP by investigating bilateral fundus excyclotorsion in unilateral SOP and comparing the features with bilateral SOP using fundus photographs. Methods: This retrospective cohort study included a total of 212 subjects who were diagnosed with unilateral SOP with hypoplasia of a single superior oblique (SO) muscle and 7 subjects with clinically diagnosed bilateral SOP. Fundus excyclotorsion measured by modified fovea–disc angles and inter-eye differences in cyclotorsion angles (the difference in fundus excyclotorsion angles: paretic eye or hypertropic eye in primary gaze–fellow eye), and subjective cyclotorsion were compared between groups of unilateral SOP with bilateral fundus excyclotorsion (SOPBE) and bilateral SOP. Results: Bilateral fundus excyclotorsion was found in 18 out of 212 patients (8.5%) in the unilateral SOP group, and 7 out of 7 patients (100%) in the bilateral SOP group. Among the 25 patients with bilateral fundus excyclotorsion, the mean angle of excyclotorsion (5.7° ± 4.7° vs. 7.6° ± 4.3°, p = 0.125) and the inter-eye differences (0.7° ± 3.6° vs. 0.5° ± 5.8°, p = 0.615) were not significantly different between the unilateral SOPBE and bilateral SOP groups. The degree of subjective excyclotorsion was significantly larger in the bilateral SOP group compared with the unilateral SOPBE group (16.0 ± 5.5 vs. 4.6 ± 4.3, p = 0.002). Conclusion: Bilateral fundus excyclotorsion was demonstrated not only in bilateral SOP, but also in unilateral SOP at a rate of 8.5%. Bilateral fundus excyclotorsion alone did not prove to be a specific sign in distinguishing bilateral SOP from unilateral SOP.

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Age‐related change and sex difference over 60s in disc‐fovea angle in Japanese population: the Nagahama Study

Abstract: Larger DFA in women than in men in their 60s and 70s suggests the possibility that age-related excyclo-shift occurs more easily in postmenopausal women compared to men of the same age.

Cited by 11 publications

References 37 publications

Automatic Estimation of Objective Cyclodeviation in Fundus Image Using Machine Learning

Automatic Estimation of Objective Cyclodeviation in Fundus Image Using Machine Learning

Assessment of objective ocular cyclodeviation under monocular condition and binocular condition using fundus photography

Bilateral Fundus Excyclotorsion in Unilateral Superior Oblique Palsy Confirmed by MR Imaging

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