Age-related change in kidney function, its influencing factors, and association with asymptomatic carotid atherosclerosis in healthy individuals—A 5-year follow-up study

Jiang, Shimin; Sun, Xuefeng; Gu, Huijie; Chen, Yunshuang; Xi, Chunsheng; Qiao, Xi; Chen, Xiangmei

doi:10.1016/j.maturitas.2012.07.014

Cited by 25 publications

(23 citation statements)

References 30 publications

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“…The GFR loss rate is tripled in subjects over 40 as compared with those under 40 in the Baltimore study [ 58 ]. A more recent study in healthy Chinese people described similar results [ 59 ].…”

Section: Aging and Aki: Causessupporting

confidence: 70%

The Aging Kidney: Increased Susceptibility to Nephrotoxicity

Wang

Bonventre

Parrish

2014

IJMS

105

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Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair.

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Section: Aging and Aki: Causessupporting

confidence: 70%

The Aging Kidney: Increased Susceptibility to Nephrotoxicity

Wang

Bonventre

Parrish

2014

IJMS

105

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“…This could be contributed by longer exposure to higher blood pressure in men throughout adulthood. The change in eGFR has been shown to be negatively associated with systolic BP, smoking, fibrinogen, and albumin/creatinine ratio [24,25]. On the other hand, high alcohol consumption in men and high physical activity in women were positively associated with eGFR.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Changes in the Cardiometabolic Profiles in Singapore Resident Adult Population: Findings from the National Health Survey 2010

Loh

Heng

et al. 2016

PLoS ONE

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We describe the centile trends of the blood pressure, glycemia and lipid profiles as well as renal function of a representative population who participated in the Singapore National Health Survey in 2010. Representative survey population was sampled in two phases, first using geographical/ residential dwelling type stratification, followed up ethnicity. 2,407 survey participants without any self-reported medical or medication history for diabetes mellitus, hypertension and dyslipidemia were included in this analysis. All biochemistry analyses were performed on Roche platforms. After excluding outliers using Tukey's criteria, the results of the remaining participants were subjected to lambda-mu-sigma (LMS) analysis. In men, systolic blood pressure increased linearly with age. By contrast, an upward inflection around late 40s was seen in women. The diastolic blood pressure was highest in men in the late 30s-50s age group, and in women in the late 50s-60s age group. All glycemia-related parameters, i.e. fasting and 2-hour plasma glucose and HbA1c concentrations increased with age, although the rate of increase differed between the tests. Total cholesterol and LDL-cholesterol concentrations increased with age, which became attenuated between the early 30s and late 50s in men, and declined thereafter. In women, total cholesterol and LDL-cholesterol concentrations gradually increased with age until late 30s, when there is an upward inflection, plateauing after late 50s. Our findings indicate that diagnostic performance of laboratory tests for diabetes may be age-sensitive. Unfavourable age-related cardiovascular risk profiles suggest that the burden of cardiovascular disease in this population will increase with aging population.

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“… 39 , 40 This difference may stem from the fact that patients with CrCl levels of <50 mL/min were excluded from the 2 phase 3 studies of G-GR and only the phase 4 study included exclusion criteria limited to the product label (patients with CrCl levels of <30 mL/min were excluded). Although kidney function generally declines with increasing age, 41 it does not appear that older patients were excluded from the studies as 64.4% of patients were older than 65 years and 29.3% were 75 years and older of age. However, findings of the current study may only apply to older adults with good kidney function, and thus age may not show as a significant factor.…”

Section: Discussionmentioning

confidence: 99%

Relationships Among Adverse Events, Disease Characteristics, and Demographics in Treatment of Postherpetic Neuralgia With Gastroretentive Gabapentin

Shaparin

Slattum

Bucior

et al. 2015

The Clinical Journal of Pain

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Objectives:To characterize risk factors for occurrence of adverse events (AEs) and treatment discontinuations due to AEs for improving safety and tolerability of treatment of postherpetic neuralgia (PHN).Methods:Patients with PHN (n=556) received 1800 mg once-daily gastroretentive gabapentin (G-GR) in 2 phase 3 and 1 phase 4 study. Safety assessments included the incidence and severity of AEs and analysis of discontinuations due to AEs. Multivariable, logistic regression analyses examined predictors of AE reporting and discontinuations due to AEs.Results:In total, 53.2% of patients reported any AE, and 12.9% discontinued because of AEs. Both AE incidence and treatment discontinuations decreased rapidly during the 2-week titration to sustained, low levels. The probability to report any AE was 0.6 for females versus 0.4 for males, whereas there were no differences in probabilities for age (less than 75 vs. 75 y and older) and race (nonwhite vs. white). Consistent with this, only female sex was a significant (P=0.0006) predictor of AE reporting. Experiencing moderate (P≤0.0001) or severe (P=0.0006) AEs, but not patient demographics, was predictive of treatment discontinuations. The probability of discontinuation due to moderate AEs was 0.4 and 0.5 for severe AEs.Discussion:The tolerability of G-GR was not affected by patient age, but was affected by AE severity. Although being female was predictive of reporting AEs, it did not influence treatment discontinuation. Given that PHN is a disease for which the risk and duration of PHN increases with age and with being female, G-GR appears to be a well-suited treatment option for PHN.

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Age-related change in kidney function, its influencing factors, and association with asymptomatic carotid atherosclerosis in healthy individuals—A 5-year follow-up study

Cited by 25 publications

References 30 publications

The Aging Kidney: Increased Susceptibility to Nephrotoxicity

The Aging Kidney: Increased Susceptibility to Nephrotoxicity

Age-Related Changes in the Cardiometabolic Profiles in Singapore Resident Adult Population: Findings from the National Health Survey 2010

Relationships Among Adverse Events, Disease Characteristics, and Demographics in Treatment of Postherpetic Neuralgia With Gastroretentive Gabapentin

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