Age-related changes for the predictors of benign prostatic hyperplasia in Chinese men aged 40 years or older

Zhang, Weidong; Shao, Weihao; Zheng, Caifang; Ge, Yongchao; Chen, Xiaorui; Zhang, Bowen; Wang, Gai-Li

doi:10.4103/aja202223

Cited by 9 publications

(3 citation statements)

References 28 publications

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“…With the continuous aging of the population, BPH has become an important public health issue, dragging down the economy and individual quality of life. [20,21] Although there are available treatment methods, their effectiveness and potential side effects are limited, which makes the task of researchers to develop more effective solutions to meet urgent needs. [22] According to the theory of Qi and blood in TCM, Qi deficiency should be tonified and blood stasis should be invigorated.…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study

Yang,

Ma,

Zhao

et al. 2024

Medicine

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Cinnamon and motherwort are traditional Chinese medicines and are often combined to treat benign prostatic hyperplasia; however, the specific therapeutic mechanisms involved remain unclear. Therefore, in this study, we applied a network pharmacology approach to investigate the potential mechanisms of action of the drug pair cinnamon and motherwort (PCM) for the treatment of benign prostatic hyperplasia. Relevant targets for the use of PCM to treat benign prostatic hyperplasia were obtained through databases. Protein–protein interactions were then identified by the STRING database and core targets were screened. Enrichment analysis was conducted through the Metascape platform. Finally, molecular docking experiments were carried out to evaluate the affinity between the target proteins and ligands of PCM. We identified 22 active ingredients in PCM, 315 corresponding targets and 130 effective targets of PCM for the treatment of benign prostatic hyperplasia. These targets were related to the PI3K-Akt, MAPK, FoxO, TNF, and IL-17 signaling pathways. Network pharmacology was used to identify the effective components and action targets of PCM. We also identified potential mechanisms of action for PCM in the treatment of benign prostatic hyperplasia. Our results provide a foundation for expanding the clinical application of PCM and provide new ideas and directions for further research on the mechanisms of action of PCM and its components for the treatment of benign prostatic hyperplasia.

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Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study

Yang,

Ma,

Zhao

et al. 2024

Medicine

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“…Shao et al pointed out that age is closely related to BPH. 20 In elderly men, kidney qi gradually becomes deficient, qi, blood, and body fluids lose the drive of healthy qi, manifesting symptoms such as soreness and weakness of the waist and knees and difficulty in urination. Jingui Shenqi Pill is used to tonify the kidney and assist yang and supplement kidney qi.…”

Section: Deficiency Of Healthy Qimentioning

confidence: 99%

Research Progress on the Treatment of Benign Prostatic Hyperplasia with Classical Prescriptions

Zhang,

Wang,

Liu

et al. 2024

Chinese medicine and natural products

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The main pathogenesis of benign prostatic hyperplasia (BPH) includes deficiency of healthy qi, blood stasis, and fluid retention. The root cause of BPH is the deficiency of healthy qi, for which Jingui Shenqi Pill and Zhenwu Decoction are used to nourish kidney qi and warm yang to promote diuresis. Blood stasis is the key pathogeneses of BPH, for which Guizhi Fuling Pill and Didang Decoction are used to dissipate blood stasis, relieve obstruction of orifices and facilitate bowel movement. Fluid retention is the most urgent symptom of BPH, for which Wuling Powder and Danggui Shaoyao Powder are used to transform qi and promote diuresis, addressing the urgent symptoms.

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“…Penelitian ini juga menyimpulkan bahwa usia diatas 61 tahun merupakan prediktor BPH. (Shao et al, 2023) Terdapat keterbatasan pada penelitian ini.…”

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Korelasi Usia, International Prostate Symptom Score, Benign Prostatic Hyperplasia Impact Index, Kualitas Hidup, dan Tingkat Keparahan Pada Penderita Benign Prostatic Hyperplasia di RSUD Ciawi

Soni,

Firmansyah,

Kurniawan

et al. 2023

Mal Health Stu J.

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Benign prostatic hyperplasia (BPH) is one of the common diseases in old male and is the common cause of lower urinary tract symptoms. The prevalence of this disease is not to be underestimated, reaching up to 80% in the age of 90 years. This disease also affects the quality of life of the patients. To find out the correlation of age, International Prostate Symptom Score (IPSS), Benign Prostatic Hyperplasia Impact Index (BII), quality of life, and severity of BPH patients. The study is done in urology clinic in Ciawi General Hospital on the period of June-July 2023. The samples are gathered with total sampling method, covering all the male patients with BPH that fulfilled the criteria. Data gathered through interview. Normality of the data is tested with Shapiro-wilk test. The correlation is tested with Pearson Correlation test or alternative of Spearman Correlation test. The study found a correlation of IPSS and BII (p-value = 0.005; r = 0.495), but no significance of age with IPSS and BII (p-value > 0.05). Strong correlation is found from quality of life with BII (p-value: < 0,001; r: 0,629), quality of life with severity based from IPSS (p-value: < 0,001; r: 0,655), and correlation between severity with IPSS and BII (p-value: 0,006; r: 0,487). Using IPSS and BII scores in clinical practice is valuable for describing a patient's severity and quality of life. We can use the results to assess the effectiveness of the treatment and measure the results. Keywords : BII, BPH, IPSS, Quality of Life ABSTRAK Pembesaran jinak prostat atau benign prostatic hyperplasia (BPH) adalah salah satu penyakit paling umum pada pria lanjut usia dan penyebab paling umum dari gejala saluran kemih bagian bawah. Angka prevalensi penyakit ini juga tidak dapat dipandang sebelah mata, mencapai 80% pada usia 90 tahun. Penyakit ini juga mempengaruhi kualitas hidup penderitanya. Mengetahui korelasi usia, skor International Prostate Symptom Score (IPSS), Benign Prostatic Hyperplasia Impact Index (BII), kualitas hidup, dan tingkat keparahan pada penderita BPH. Penelitian ini dilakukan di Poli Urologi RSUD Ciawi pada periode Juni – Juli 2023. Sampel pada penelitian ini diambil dengan metode total sampling, mencakup seluruh laki-laki yang menderita BPH yang memenuhi kriteria. Data diperoleh melalui wawancara. Uji normalitas data dilakukan dengan menggunakan uji Shapiro-Wilk. Uji korelasi pada penelitian ini menggunakan uji Pearson Correlation atau uji alternatif Spearman Correlation. Didapatkan bahwa terdapat korelasi cukup yang bermakna antara IPSS dengan BII (p-value : 0,005 dan r: 0,495), tetapi tidak terdapat korelasi yang bermakna secara statistik antara usia dengan IPSS dan BII (p-value > 0,05). Terdapat korelasi kuat yang bermakna secara signifikan antara kualitas hidup dengan BII (p-value: < 0,001; r: 0,629), kualitas hidup dengan tingkat keparahan menurut IPSS (p-value: < 0,001; r: 0,655), dan korelasi cukup pada tingkat keparahan menurut IPSS dengan BII (p-value: 0,006; r: 0,487).Penggunaan skor IPSS dan BII dalam praktik klinis membantu menggambarkan tingkat keparahan pasien, dan kualitas hidup pasien. Penelian ini membantu kita dalam mengobati dan mengevaluasi keberhasilan terapi. Kata Kunci: BII, BPH, IPSS, Kualitas Hidup

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Age-related changes for the predictors of benign prostatic hyperplasia in Chinese men aged 40 years or older

Cited by 9 publications

References 28 publications

Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study

Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study

Research Progress on the Treatment of Benign Prostatic Hyperplasia with Classical Prescriptions

Korelasi Usia, International Prostate Symptom Score, Benign Prostatic Hyperplasia Impact Index, Kualitas Hidup, dan Tingkat Keparahan Pada Penderita Benign Prostatic Hyperplasia di RSUD Ciawi

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