Age-related changes in adipose tissue metabolomics and inflammation, cardiolipin metabolism, and ferroptosis markers in female aged rat model

Wang, Zhuang-Zhi; Li, Fanghui; Ni, Pin-Shi; Sun, Lei; Zhang, Chen-Kai; Li, Bo-Ming; He, Jia-Han; Yu, Xiao-Ming; Liu, Yunqing

doi:10.1016/j.bbrc.2023.06.027

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…It can also be used for liquid nitrogen impact crushing and the use of French Press (for plant tissue). The frozen powder tissue was then extracted by cold methanol (4 v/g) or 0.1% perchloric acid to precipitate and inactivate the enzyme [27], and the precipitated protein was removed by centrifugation. Add chloroform and water to remove lipids [28,29].…”

Section: Whole Tissuesmentioning

confidence: 99%

Review on analytical technologies and applications in metabolomics

MENG,

LIU,

et al. 2024

BIOCELL

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Over the past decade, the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry, nuclear magnetic resonance, and multivariate statistics. Currently, metabolomics garners widespread application across diverse fields including drug research and development, early disease detection, toxicology, food and nutrition science, biology, prescription, and chinmedomics, among others.Metabolomics serves as an effective characterization technique, offering insights into physiological process alterations in vivo. These changes may result from various exogenous factors like environmental conditions, stress, medications, as well as endogenous elements including genetic and protein-based influences. The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods, poised to further broaden the scope of this domain. Today, metabolomics has evolved into a valuable and widely accepted instrument in the life sciences. However, comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant. This review aims to fill that gap, providing an overview of current trends and recent advancements in metabolomics. Particular emphasis is placed on sample preparation, sophisticated analytical techniques, and their applications in life science research.

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Section: Whole Tissuesmentioning

confidence: 99%

Review on analytical technologies and applications in metabolomics

MENG,

LIU,

et al. 2024

BIOCELL

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Iron: The silent culprit in your adipose tissue

Moreno‐Navarrete,

Fernández‐Real

2023

Obesity Reviews

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SummaryIron plays a vital role in essential biological processes and requires precise regulation within the body. Dysregulation of iron homeostasis, characterized by increased serum ferritin levels and excessive accumulation of iron in the liver, adipose tissue, and skeletal muscle, is associated with obesity and insulin resistance. Notably, iron excess in adipose tissue promotes adipose tissue dysfunction. As optimal adipose tissue function is crucial for maintaining a healthy phenotype in obesity, a comprehensive understanding of iron homeostasis in adipose tissue is imperative for designing new therapeutic approaches to improve and prevent adipose tissue dysfunction. Here, we conducted a review of relevant studies, focusing on and providing valuable insights into the intricate interplay between iron and adipose tissue. It sheds light on the impact of iron on adipogenesis and the physiology of both white and brown adipose tissue. Furthermore, we highlight the critical role of key modulators, such as cytosolic aconitase, mitochondria, and macrophages, in maintaining iron homeostasis within adipose tissue.

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Age-related changes in adipose tissue metabolomics and inflammation, cardiolipin metabolism, and ferroptosis markers in female aged rat model

Cited by 2 publications

References 59 publications

Review on analytical technologies and applications in metabolomics

Review on analytical technologies and applications in metabolomics

Iron: The silent culprit in your adipose tissue

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