Age-related changes in catalase activity and its inhibition by manganese (II) chloride in the brain of two species of poikilothermic vertebrates

Jena, B.S.; Nayak, Shivananda; Patnaik, B.K.

doi:10.1016/s0167-4943(97)00038-1

Cited by 15 publications

(5 citation statements)

References 35 publications

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“…Other studies showed that CAT enzyme activity levels were highly active in the liver and kidney, in contrast to the specific activity of brain CAT, which was found to be lower. Jena et al found that CAT activity was minimal in the brain tissue compared to other studied tissues [41].…”

Section: Discussionmentioning

confidence: 99%

The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats

2018

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Cisplatin is one of the most active cytotoxic agents in cancer treatment. To clarify the interaction with mitochondria, we hypothesize that the activities of mitochondrial electron transport chain (ETC) enzymes succinate dehydrogenase (SDH) and cytochrome c oxidase (COX), nucleotide levels, as well as levels of catalase (CAT) enzyme and membrane lipid peroxidation (LPO) can be affected by cisplatin. There was a significant decrease of both SDH and COX activities in the lung, heart, and brain tissues at the 1st day after cisplatin exposure, and the observed decreased levels of adenosine triphosphate (ATP) and adenosine diphosphate (ADP) in comparison with the control could be because of cisplatin-induced mitochondrial dysfunction. The investigations suggested that cisplatin inhibits SDH, COX, and ATP synthase. The higher LPO level in the studied tissues after 1 and 4 days post-exposure to cisplatin compared to control can be inferred to be a result of elevated electron leakage from the ETC, and reactive oxygen species (ROS) can lead to wide-ranging tissue damage such as membrane lipid damage. Consequently, it was observed that capsaicin may have a possible protective effect on ETC impairment caused by cisplatin. The activities of SDH and COX were higher in heart and brain exposed to cisplatin + capsaicin compared to cisplatin groups, while LPO levels were lower. The investigated results in the cisplatin + capsaicin groups suggested that the antioxidant capacity of capsaicin scavenges ROS and prevents membrane destruction.

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Section: Discussionmentioning

confidence: 99%

The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats

2018

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“…Particularly in fish, the development of antioxidant defences with ageing and longevity or MSLP has not been fully investigated. The extant data do not show a clear trend (Wdzieczak et al, 1982;Otto and Moon, 1996;Jena et al, 1998;Sanz et al, 2001).…”

Section: Brainmentioning

confidence: 97%

Relationship between brain and liver oxidative state and maximum lifespan potential of different fish species

Sanz¹,

Trenzado²,

Castro³

et al. 2013

Comparative Biochemistry and Physiology Part A: Molecular &

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“…SOD and GR activities in liver and extrahepatic tissues of trout were found to decrease with age, while changes in GPX and CAT with age were not evident in either species. Jena et al (1998) reported that brain catalase activity insignificantly changed with age in the freshwater murrel (Channa punctatus). However, these same authors (Nayak et al, 1999) indicated that peroxidase activity in the brain and liver of this fish declined only during maturation (young vs. middle-aged fish), whereas during senescence the enzyme activity increased in the liver but remained stable in the brain.…”

Section: Antioxidant Defenses and Agementioning

confidence: 99%

Antioxidant Defenses in Fish: Biotic and Abiotic Factors

Martínez‐Álvarez

Morales

Sanz

2005

Rev Fish Biol Fisheries

1,002

456

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Age-related changes in catalase activity and its inhibition by manganese (II) chloride in the brain of two species of poikilothermic vertebrates

Cited by 15 publications

References 35 publications

The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats

The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats

Relationship between brain and liver oxidative state and maximum lifespan potential of different fish species

Antioxidant Defenses in Fish: Biotic and Abiotic Factors

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