Age‐related changes in childhood wheezing characteristics: A whole population study

Jurca, Maja; Pescatore, Aniña M.; Goutaki, Myrofora; Spycher, Ben D.; Beardsmore, Caroline; Kuehni, Claudia E.

doi:10.1002/ppul.23783

Cited by 17 publications

(20 citation statements)

References 40 publications

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“…Our finding that 28% of the 12‐year‐old asthmatics only had asthma with a cold is notable and was higher than we expected. However, the percentage was in line with British findings . In a large population‐based cohort of children from Leicestershire, UK, Jurca et al found that the relative prevalence of episodic viral wheeze in the children aged 10–13 was 40%.…”

Section: Discussionsupporting

confidence: 75%

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Antibiotics in the first week of life were associated with atopic asthma at 12 years of age

et al. 2018

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AimThis study explored the prevalence of atopic and nonatopic asthma in 12‐year‐old children and whether they were associated with different risk factors. In particular, we wanted to analyse whether receiving antibiotics during the first week of life was associated with asthma at that age.MethodsData were obtained from a longitudinal cohort study of 5654 Swedish children born in 2003. The parents answered questionnaires from the age of six months until 12 years. The response rate at 12 years was 3637/4777 (76%).ResultsAt 12 years, 6.4% reported current doctor‐diagnosed asthma. Treatment with antibiotics during the first week of life was associated with an increased risk of atopic asthma, with an adjusted odds ratio of 2.2 and 95% confidence interval of 1.2–4.2. Being born small for gestational age was associated with an increased risk of nonatopic asthma, with an adjusted odds ratio of 3.8 and 95% confidence interval of 1.1–13.7. Asthma that only occurred with colds was reported by 28%.ConclusionAntibiotic treatment during the first week of life was associated with an increased risk of atopic asthma at 12 years, suggesting an immune‐mediated effect. Being born small for gestational age increased the risk of nonatopic asthma.

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Section: Discussionsupporting

confidence: 75%

“…However, the percentage was in line with British findings . In a large population‐based cohort of children from Leicestershire, UK, Jurca et al found that the relative prevalence of episodic viral wheeze in the children aged 10–13 was 40%. That means that four in 10 children with wheeze only wheezed during respiratory infections.…”

Section: Discussionsupporting

confidence: 75%

Antibiotics in the first week of life were associated with atopic asthma at 12 years of age

et al. 2018

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“…Acute wheezing with bronchoconstriction is most common before school age compared to any other age group . Furthermore, acute exacerbations of asthma account for approximately 10% of emergency visits in children and result in hospitalization of 20% to 40% of cases .…”

Section: Introductionmentioning

confidence: 99%

In vitro drug delivery performance of five valved holding chambers with and without facemasks

Csonka

Lehtimäki

2019

Pediatric Pulmonology

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Background Valved holding chambers (VHCs) are essential for efficient pulmonary delivery of inhaled medication in preschool children. The numerous devices in the market vary in material, aerodynamic characteristics, volume, valve properties, and mask design. Drug delivery is affected by the VHC characteristics as well as by the age and breathing pattern of the child. Methods We measured the drug delivery efficacy of five VHCs widely available in the market, evaluated the effect of facemasks and tested the differences between manufacturing lots. A breathing simulator was used to mimic normal (respiratory rate [RR] 25/minute and tidal volume (VT) 200 mL) and obstructive (RR 50/minute and VT 50 mL) breathing of infants and toddlers. Results Salbutamol output was significantly higher with a normal breathing pattern compared to the obstructive breathing pattern in most VHCs. Without masks, the differences in the median in vitro filter doses of salbutamol were mainly from 2 to 10‐fold among different types of VHCs. With masks, there was a greater than 20‐fold difference in drug delivery capacity between the most and least effective devices. Most VHCs had a notable variation of performance between individual devices from different lots within the same brand. Conclusions There was an extreme variation in the salbutamol delivery performance among different types of VHCs for both normal and obstructive pediatric breathing patterns with and without masks. This magnitude of performance variability can have significant and unpredictable clinical implications.

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“…In children, the prevalence of current wheezing varies significantly by geography and may be as high as 30% while the prevalence of reported “wheeze ever” may reach close to 50% . A recent study of a large population‐based cohort of children ( n = 7670) found “current wheeze” most commonly reported in 1‐year‐olds (36%), decreasing to 17% in adolescents at 14‐17 years of age …”

Section: Introductionmentioning

confidence: 99%

The highs and lows of wheezing: A review of the most popular adventitious lung sound

Pasterkamp

2017

Pediatric Pulmonology

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Wheezing is the most widely reported adventitious lung sound in the English language. It is recognized by health professionals as well as by lay people, although often with a different meaning. Wheezing is an indicator of airway obstruction and therefore of interest particularly for the assessment of young children and in other situations where objective documentation of lung function is not generally available. This review summarizes our current understanding of mechanisms producing wheeze, its subjective perception and description, its objective measurement, and visualization, and its relevance in clinical practice.

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Age‐related changes in childhood wheezing characteristics: A whole population study

Abstract: Knowledge of these age-related changes in wheezing illness is informative for health care planning and the design of future research projects and questionnaires.

Cited by 17 publications

References 40 publications

Antibiotics in the first week of life were associated with atopic asthma at 12 years of age

Antibiotics in the first week of life were associated with atopic asthma at 12 years of age

In vitro drug delivery performance of five valved holding chambers with and without facemasks

The highs and lows of wheezing: A review of the most popular adventitious lung sound

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