Age-related changes in cortical bone mass: data from a German female cohort

Abstract

To describe data from digital radiogrammetry (DXR) in an unselected German female cohort over a wide age range. Using a retrospective study design we analyzed radiographs of the hand from 540 German women (aged 5-96 years) using an automated assessment of cortical thickness, metacarpal index (MCI), and estimated cortical bone mineral density (DXR-BMD) on digitized radiographs. Both hands were radiographed in 97 women. In this group DXR-BMD and cortical thickness were significantly higher in the right metacarpals while there was no significant difference in MCI. To study the association with age we differentiated young (<20 years), middle-aged (20-45 years), and an older patients (>45 years). In young women all parameters increased significantly with age in a linear fashion (r=0.8 for DXR-BMD, r=0.7 for MCI). In those aged 25-45 years DXR-BMD and MCI were highest (peak bone mass). In women aged 45 or older all parameters decreased with age in an almost linear fashion with an annual change ranging from 0.7% to 0.9%. Our results for an unselected German female cohort indicate that DXR is a reliable, widely available osteodensitometric technique based on the refinement of conventional radiogrammetry. These findings are comparable to those from other studies and represent a valid resource for clinical application and for comparisons with other ethnic groups.

Age-related changes of bone strength phenotypes: observational follow-up study of hand bone mineral density

“…3). This threshold closely matches the data obtained from cross-sectional studies by several other teams on very ethnically different populations, sampled from the various regions of Europe and Asia [14,39,40]. However, our present study also suggests the existence of an additional threshold (at age 60), with a much slower reduction in BMD afterwards.…”

“…In our sample the age of peak bone mass observed in females was very similar to what was found in several other studies on various skeletal sites including the hand [14,39,40], but it contradicts the previous data of others [11,[41][42][43] regarding the peak bone mass. Despite two longitudinal studies that showed that BMD in a distal site increases up to age 50 in males [27] and females [17], our results support the notion [33,44] that bone loss starts during the third decade of life.…”

An update on the assessment of osteoporosis using radiologic techniques

“…Digital X-ray radiogrammetry (DXR) significantly reduced the intra-and inter-observer error and increased precision, whereas newer systems also provide texture analysis to measure BMD [30]. Normative data of DXR have been reported, suggesting its potential use as a screening tool [31]. It has been shown that DXR is able to predict femoral neck osteopenia as well as wrist and vertebral fractures [32,33].…”

Mini-İmplantların Devrilmesini Önlemede Yeni Bir Yaklaşım

“…Another study emphasized that special care should be taken when using mini-implants in patients with a high mandibular plane angle, because of potential thin cortical bone, in order not to have failures (8). Similar concerns are valid also for children, who would have lower bone mass than adults (27). Our results suggested that mini-implants inserted with MIR provided greater primary stability and increased anchorage values, as seen in the higher values of tangential loading test, than was provided by miniimplants alone.…”

“…Bir başka çalışmada, yüksek mandibular düzlem açısına sahip hastalarda potansiyel ince kortikal kemik varlığından dolayı başarısızlık olmaması için mini-implantların uygulanmasında özel dikkat gerektiği vurgulanmıştır (8). Benzer kaygılar, yetişkinlere göre daha az kemik yoğunluğuna sahip çocuk hastalar için de geçerlidir (27).…”