Age-related changes in detection of spatial novelty

Maasberg, David W.; Shelley, Laura E.; Gilbert, Paul E.

doi:10.1016/j.bbr.2011.12.024

Cited by 5 publications

(6 citation statements)

References 45 publications

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“…This may be related to the fact that with the movement of the already familiar object a less subtle spatial and/or environmental change took place. Studies reporting age‐related short‐term deficits in the object place task, however, also have been reported though in a different rat strain, testing procedure and mainly in a much older cohort (Shukitt‐Hale et al, ; Maasberg et al, ). It implies that the sensitivity of detected age‐related deficits may rely on the specific rat strain, test and aging stage.…”

Section: Discussionmentioning

confidence: 99%

“…Male Wistar rats (7‐8 weeks and 7‐8 months old) were housed in groups of four and maintained on a 12‐h light/12‐h dark cycle. Seven‐to eight‐month‐old rats were considered “older” to distinguish them from work conducted with “aged” rats of more than 20 months (Shukitt‐Hale et al, ; Maasberg et al, ). The animals were assessed in parallel as two separate cohorts.…”

Section: Methodsmentioning

confidence: 99%

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Early age‐dependent impairments of context‐dependent extinction learning, object recognition, and object‐place learning occur in rats

2013

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The hippocampus is vulnerable to age-dependent memory decline. Multiple forms of memory depend on adequate hippocampal function. Extinction learning comprises active inhibition of no longer relevant learned information concurrent with suppression of a previously learned reaction. It is highly dependent on context, and evidence exists that it requires hippocampal activation. In this study, we addressed whether context-based extinction as well as hippocampus-dependent tasks, such as object recognition and object-place recognition, are equally affected by moderate aging. Young (7-8 week old) and older (7-8 month old) Wistar rats were used. For the extinction study, animals learned that a particular floor context indicated that they should turn into one specific arm (e.g., left) to receive a food reward. On the day after reaching the learning criterion of 80% correct choices, the floor context was changed, no reward was given and animals were expected to extinguish the learned response. Both, young and older rats managed this first extinction trial in the new context with older rats showing a faster extinction performance. One day later, animals were returned to the T-maze with the original floor context and renewal effects were assessed. In this case, only young but not older rats showed the expected renewal effect (lower extinction ratio as compared to the day before). To assess general memory abilities, animals were tested in the standard object recognition and object-place memory tasks. Evaluations were made at 5 min, 1 h and 7 day intervals. Object recognition memory was poor at short-term and intermediate time-points in older but not young rats. Object-place memory performance was unaffected at 5 min, but impaired at 1 h in older but not young rats. Both groups were impaired at 7 days. These findings support that not only aspects of general memory, but also context-dependent extinction learning, are affected by moderate aging. This may reflect less flexibility in revising hard-wired knowledge or reduced adaptability to new learning challenges.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Early age‐dependent impairments of context‐dependent extinction learning, object recognition, and object‐place learning occur in rats

2013

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“…Additionally, age-related structural and physiological changes in the neural system involved in spatial recognition memory, such as hippocampal formation ( Akkerman et al 2012 ; Maasberg et al 2012 ), can be a main target of EGb through modulating molecular mechanisms related to memory loss. We have demonstrated that 1.0 g/kg EGb improved short-term spatial memory and preventive effects in the prefrontal cortex in middle-aged rats ( Ribeiro et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Standardized extract ofGinkgo bilobatreatment and novelty on the weak encoding of spatial recognition memory in rats

2023

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Long-term memory (LTM) formation is dependent on neurochemical changes that guarantee that a recently formed memory (short-term memory [STM]) remains in the specific neural circuitry via the consolidation process. The persistence of recognition memory has been evidenced by using behavioral tagging in young adult rats, but it has not been effective on aging. Here, we investigated the effects of treatment with a standardized extract ofGinkgo biloba(EGb) associated with novelty on the consolidation of object location memory (OLM) and its persistence after weak training of spatial object preference in young adult and aged rats. The object location task used in this study included two habituation sessions, training sessions associated or not associated with EGb treatment and contextual novelty, and short-term or long-term retention testing sessions. Altogether, our data showed that treatment with EGb associated with novelty close to the time of encoding resulted in STM that lasted for 1 h and persisted for 24 h for both young adult and aged rats. In aged rats, the cooperative mechanisms induced robust long-term OLM. Our findings support and extend our knowledge about recognition memory in aged rats and the modulating effects of EGb treatment and contextual novelty on the persistence of memory.

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“…A recent study with animals aimed at examining age-related changes in the detection of spatial novelty (e.g., M et al 3 ), namely, verifying if old rats showed signi cant de cits compared to young rats in detecting spatial displacement of objects, showed that aged rats do not detect changes in object-place associations when exploring an environment. In this regard, some studies in elderly and young population investigating the neural correlates of aging-related changes during encoding and retrieval of spatial contextual memory (e.g., K et al 4 ) and aspects of episodic memory (e.g., P et al…”

Section: Introductionmentioning

confidence: 99%

Visuomotor memory in elderly: effect of a physical exercise program

Silva

Carvalho

Rodrigues

et al. 2014

Rev. bras. educ. fís. esporte

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Memory, namely visuomotor memory, is one of the most essential cognitive functions in elder's life. Among others, regular exercise seems to be an important factor in counteracting age-related-cognitive skills changes and thus prevent memory loss. However, in spite of the importance of visuomotor memory, the results of the scarce studies concerning the infl uence of exercise on this capacity are contradictory. The aim of this study was to investigate the effect of physical exercise (PE) in visuomotor memory (VMM) of elderly adults in function of gender and age. VMM (time spent in performing the test and errors during the execution) of 74 subjects aged 60-90 years, being 36 practitioners of PE (P -mean age of 70.22 ± 0.90 years) and 38 non-practitioners (NP -mean age of 68.26 ± 1.12 years) were assessed by VMM Test. The results showed that: a) P presented a better performance in the time of performing the test and in the number of errors committed compared to NP; b) Gender and age did not infl uence the VMM performance. Data suggest that PE seems to have positive effect in the VMM, independently of gender and age.

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Age-related changes in detection of spatial novelty

Cited by 5 publications

References 45 publications

Early age‐dependent impairments of context‐dependent extinction learning, object recognition, and object‐place learning occur in rats

Early age‐dependent impairments of context‐dependent extinction learning, object recognition, and object‐place learning occur in rats

Standardized extract ofGinkgo bilobatreatment and novelty on the weak encoding of spatial recognition memory in rats

Visuomotor memory in elderly: effect of a physical exercise program

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