Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus

Favrelière, Sylvie; Stadelmann-Ingrand, Sabrina; Huguet, François; Javel, Dominique de; Piriou, Alain; Tallineau, C.; Durand, Georges

doi:10.1016/s0197-4580(00)00170-6

Cited by 111 publications

(75 citation statements)

References 49 publications

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“…In agreement with this suggestion, one study reported a decrease in brain mRNA expression of DHA-selective iPLA 2 in 24-and 30-month-old rats compared to 4-month-old animals and an increase in pro-inflammatory thromboxane A 2 concentration (Aid and Bosetti 2007), suggesting increased brain DHA half-life due to reduced consumption and upregulated AA metabolism during aging, respectively (DeMar et al 2004). The implication of altered brain AA and DHA metabolism with age on brain PUFA concentrations is controversial since some but not all studies reported age-related changes in PUFA composition in rodents and postmortem human brain (Soderberg et al 1990;Lopez et al 1995;Favrelere et al 2000;Giusto et al 2002).…”

Section: Ementioning

confidence: 99%

“…With age, levels of DHA in rat and human brain have been reported to decrease in some but not all studies (Soderberg et al 1990;Lopez et al 1995;Favrelere et al 2000;Giusto et al 2002), and in humans, a low plasma DHA concentrations was associated with age-related cognitive impairment (Conquer et al 2000). One explanation for these observations is that the liver's capacity to synthesize DHA from its dietary available precursor α-LNA is reduced because of reduced activity of some enzymes involved in DHA biosynthesis (Horrobin 1981;Bordoni et al 1988;Bourre and Piciotti 1992).…”

mentioning

confidence: 99%

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RETRACTED ARTICLE: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver

Gao

Taha

et al. 2012

AGE

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Docosahexaenoic acid (DHA,, an n-3 polyunsaturated fatty acid (PUFA) found at high concentrations in brain and retina and critical to their function, can be obtained from fish products or be synthesized from circulating α-linolenic acid (α-LNA, 18:3n-3) mainly in the liver. With aging, liver synthetic enzymes are reported reduced or unchanged in the rat. To test whether liver synthesis-secretion of DHA from α-LNA changes with age, we measured whole-body DHA conversion coefficients and rates in unanesthetized adult male Fischer-344 rats aged 10, 20, or 30 months, fed an eicosapentaenoic acid (EPA, 20:5n-3)-and DHAcontaining diet. Unesterified [U-13 C]α-LNA bound to albumin was infused intravenously for 2 h, while [ 13 C]-esterified n-3 PUFAs were measured in arterial plasma, as were unlabeled unesterified and esterified PUFA concentrations. Plasma unesterified n-3 PUFA concentrations declined with age, but esterified n-3 PUFA concentrations did not change significantly. Calculated conversion coefficients were not changed significantly with age, whereas synthesis-secretion rates (product of conversion coefficient and unesterified plasma α-LNA concentration) of esterified DHA and n-3 DPA were reduced. Turnovers of esterified n-3 PUFAs in plasma decreased with age, whereas half-lives increased. The results suggest that hepatic capacity to synthesize DHA and other n-3 PUFAs from circulating α-LNA is maintained with age in the rat, but that reduced plasma α-LNA availability reduces net synthesis-secretion. As unesterified plasma DHA is the form that is incorporated preferentially into brain phospholipid, its reduced synthesis may be deleterious to brain function in aged rats.

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Section: Ementioning

confidence: 99%

mentioning

confidence: 99%

RETRACTED ARTICLE: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver

Gao

Taha

et al. 2012

AGE

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“…94)), two families of lipid signals with marked anti-inflammatory and neuroprotective effects [95][96][97] ; and a free-radical-mediated peroxidation pathway that leads to the production of neuroprostanes, which are involved in oxidative stress 98 . Both mechanisms may be relevant to the alterations in docosahexaenoic acid levels observed in aging and Alzheimer's disease [95][96][97][99][100][101][102] . Lipids might act as direct effectors of signal transduction by directly binding to G-protein-coupled receptors (green oval shape) and nuclear receptors (blue oval shape).…”

Section: Signalling On Demandmentioning

confidence: 99%

A neuroscientist's guide to lipidomics

2007

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| Nerve cells mould the lipid fabric of their membranes to ease vesicle fusion, regulate ion fluxes and create specialized microenvironments that contribute to cellular communication. The chemical diversity of membrane lipids controls protein traffic, facilitates recognition between cells and leads to the production of hundreds of molecules that carry information both within and across cells. With so many roles, it is no wonder that lipids make up half of the human brain in dry weight. The objective of neural lipidomics is to understand how these molecules work together; this difficult task will greatly benefit from technical advances that might enable the testing of emerging hypotheses.

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“…Most of the studies on aging report a significant decrease in the level and turnover of PUFA [40,98,117,130], especially in the hippocampus, cortex, striatum and hypothalamus. During aging, there is a significant change in the transition temperature (see above), a change which is more profound in Alzheimer patients [46].…”

Section: Role Of Fatty Acids In Aging Neuronal Membranementioning

confidence: 99%

The role of polyunsaturated fatty acids in restoring the aging neuronal membrane

Yehuda¹,

Rabinovitz²,

Carasso³

et al. 2002

Neurobiology of Aging

353

200

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In addition to a gradual loss of neurons in various brain regions, major biochemical changes in the brain affect the neuronal membrane that is the "site of action" for many essential functions including long-term potentiation (LTP), learning and memory, sleep, pain threshold, and thermoregulation. Normal physiological functioning includes the transmission of axonal information, regulation of membrane-bound enzymes, control of ionic channels and various receptors. All are highly dependent on membrane fluidity, where rigidity is increased during aging. The significantly higher level of cholesterol in aging neuronal membrane, the slow rate of cholesterol turnover, and the decreased level of total polyunsaturated fatty acids (PUFA) may result from poor passage rate via the blood-brain barrier, or from a decreased rate of incorporation into the membrane, or a decrease in the activities of delta-6 and delta-9 desaturase enzymes. The added oxidative stress, which leads to an increase of free radicals leading to a decrease in membrane fluidity, may respond to a restricted diet, and thereby overcome the damaging effects of the free radicals. A central focus of this review is that a specific ratio of n-3/n-6 PUFA can restore many of these age-related effects.

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Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus

Cited by 111 publications

References 49 publications

RETRACTED ARTICLE: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver

RETRACTED ARTICLE: Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver

A neuroscientist's guide to lipidomics

The role of polyunsaturated fatty acids in restoring the aging neuronal membrane

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