Age-related changes in intraocular pressure in a large japanese population

Nomura, Hideki; Shimokata, Hiroshi; Ando, Fujiko; Miyake, Yoichi; Kuzuya, Fumio

doi:10.1016/s0161-6420(99)90417-7

Cited by 141 publications

(155 citation statements)

References 30 publications

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“…40,45 Several Japanese studies adjusting for the effect of BP as we did here also report a negative correlation between age and IOP. 46,47 Previous studies have shown that BP has independent positive associations with both IOP and age, 48-51 which suggests that BP should be adjusted as an independent variable when investigating the relationship between age and IOP.We found diabetes and black race to be associated with higher IOP, which is consistent with previous reports. 39,48,49,[52][53][54][55] Male gender is associated with greater CDR, which is in agreement with the findings of a higher risk of POAG in the male gender reported by the Barbados Eye Study, Framingham Eye Study, and the Long Island Glaucoma Case-Control Study.…”

supporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Determinants and Heritability of Intraocular Pressure and Cup-to-Disc Ratio in a Defined Older Population

et al. 2005

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Purpose-To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design-Family-based cohort study.Participants-Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships.Methods-Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP.Main Outcome Measures-Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR.Results-We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004).Conclusions-In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.Primary open-angle glaucoma (POAG) is the second most common cause of blindness in the world 1 and affects approximately 2.2 million Americans. 2 Although the diagnosis of POAG centers on the characteristic excavation and atrophy of the optic nerve head and functional deficit measured by visual field (VF) change, 3 the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) have not been studied extensively thus far, despite the wellestablished role of heredity in POAG. In this study, we estimate the heritability of IOP and CDR from a cohort of sibships recruited through the Salisbury Eye Evaluation study. In addition, we also report the distribution of IOP and CDR among siblings of glaucomatous probands versus siblings of normal probands. Materials and Methods Subjects and General DesignBetween 1993 and 1995, a random sample of potential participants (ages 65 to 84 years) was chosen from the Health Care Financing Administration Medicare database and recruited from Salisbury, located on the Eastern Shore of Maryland, to engage in the population-based Salisbury Eye Evaluation study. 28 The cohort was invited for a follow-up examination including VF testing, optic nerve head imaging, and IOP measurement. All subjects with abnormal scr...

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supporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Determinants and Heritability of Intraocular Pressure and Cup-to-Disc Ratio in a Defined Older Population

et al. 2005

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“…Therefore, we assessed the influence of age on IOP with both cross-sectional and longitudinal analyses by enrolling a large population. 8 In the cross-sectional analysis, average IOP increased from 12.7 mm Hg in subjects in their 20s to 14.0 mm Hg in those in their 40s. The total slope of tendency showed a positive value of 0.038 in the cross-sectional study.…”

Section: Discussionmentioning

confidence: 93%

Longitudinal analysis of age-related changes in intraocular pressure in South Korea

Baek

Kee

Suh

2015

Eye

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Purpose To assess the changes in intraocular pressure (IOP) with age in South Korea Methods Subjects aged 20-79 who had been receiving health examinations at a university hospital were enrolled. They completed physical and ophthalmic examinations. Subjects with ocular disease that could possibly affect their IOP were excluded. The relationships between IOP and age, blood pressure, heart rate, body mass index, blood chemistry, and electrolyte were analyzed using a linear mixed model. Results Of the 33 712 subjects, 31 857 participants were enrolled. In a cross-sectional analysis, IOP also showed a negative correlation in all age groups (respectively, Po0.001). In particular, patients in their 60s~80s had a less steep decreasing slope of IOP with age than patients in their 20s~30s (correlation coefficient − 0.260 and − 0.168, respectively). In longitudinal analysis, negative trend was shown in the slope of tendency in total subjects. When analyzing the effect of gender on the relationship between age and IOP, females had a less steep decreasing slope of IOP with age than males by 0.05 mm Hg. With regard to systemic parameters, systolic blood pressure and heart rate were positively correlated with IOP (Po0.001). Conclusion IOP was significantly decreased with age, although the amount of change was small. In women and older age groups, IOP was less decreased than that of men and young age groups. In addition, IOP was positively associated with systolic blood pressure and heart rate.

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“…In several population-based studies BP and IOP have been reported to be positively associated in both healthy individuals [8-11] and open-angle glaucoma (OAG) subjects [12-17]. In some studies this association was found for systolic BP, but not for diastolic BP [10, 11].…”

Section: From Pp To Its Principal Components: Bp and Iopmentioning

confidence: 99%

“…In some studies this association was found for systolic BP, but not for diastolic BP [10, 11]. Also, most studies report a positive association between age and IOP [8, 9, 12, 13, 18, 19], while a negative association has been reported by few Japanese studies [11, 20].…”

Section: From Pp To Its Principal Components: Bp and Iopmentioning

confidence: 99%

Weighing in Ocular Perfusion Pressure in Managing Glaucoma

Topouzis

Founti²

2009

TOOPHTJ

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The role of vascular risk factors in glaucoma is increasingly being supported by the literature, with the association between low ocular perfusion pressure (PP) and glaucoma being the most consistent result. However, we need to be cautious when interpreting these results and consider all possible confounders in the observed associations. While we assess PP through its principal components, the weight of intraocular pressure (IOP) and blood pressure (BP) in the PP equation remains unknown. Also, the role of PP in glaucoma needs to be elucidated with regards to IOP and BP fluctuation during the 24hour period and the effect of IOP-lowering and BP-lowering treatment. The complexity of the interaction of PP with other potential risk factors for glaucoma means that PP cannot be currently considered in the assessment of an individual patient. The role of PP in glaucoma warrants further research and randomized clinical trials assessing PP should include vision and/or structure preservation as end-points and ideally address all of the above issues.

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Age-related changes in intraocular pressure in a large japanese population

Cited by 141 publications

References 30 publications

Determinants and Heritability of Intraocular Pressure and Cup-to-Disc Ratio in a Defined Older Population

Determinants and Heritability of Intraocular Pressure and Cup-to-Disc Ratio in a Defined Older Population

Longitudinal analysis of age-related changes in intraocular pressure in South Korea

Weighing in Ocular Perfusion Pressure in Managing Glaucoma

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