Age-related changes in intraventricular kinetic energy: a physiological or pathological adaptation?

Wong, James; Chabiniok, Radomí­r; deVecchi, Adelaide; Dedieu, Nathalie; Sammut, Eva; Schaeffter, Tobias; Razavi, Reza

doi:10.1152/ajpheart.00075.2015

Cited by 33 publications

(33 citation statements)

References 41 publications

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“…This increase in residual volume is consistent with the decreased through-plane flow in the apex (since residual flow pathlines are typically located in or near the apex) and with the notion of increased stasis post MI. Our control data have similar flow rates to those reported in 1995 [21] and similar KE values to those reported in 2015 [22] and 2016 [23] in healthy controls. Our control data however displays a greater fraction of flow in the direct flow compartment and less in the residual volume compartment than Eriksson et al found in 2010 [19] and 2013 [24].…”

Section: Discussionsupporting

confidence: 90%

Reduced regional flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI

et al. 2019

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BackgroundAcute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI.Methods4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66 ± 12yo; prospectively acquired in 2016–2017) and 19 healthy volunteers (10 males; 40 ± 16yo; retrospective from 2010 to 2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates.ResultsPeak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P = 0.01) and apex (fitted reduction = 1.4 L/min; P = 0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P = 0.01).ConclusionsA regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.

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Section: Discussionsupporting

confidence: 90%

Reduced regional flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI

et al. 2019

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“…Since these measures reflect the hemodynamics of the entire LV, and we found that the flow in the LV apex was most acutely affected in our anterior AMI cohort, it follows that the global KE measures would be less sensitive to post-MI flow changes in this cohort than regional flow measures in the apex. Our control data have similar flow rates to those reported in 1995 [20] and similar KE values to those reported in 2015 [21] and 2016 [22] in healthy controls. Peak systolic flow in the LV base was negatively correlated with heart rate and circumferential strain and positively correlated with stroke volume and ejection fraction.…”

Section: Discussionsupporting

confidence: 90%

Reduced flow in the left ventricular apex after anterior acute myocardial infarction: a case control study using 4D flow MRI

Corrado

Macdonald

François

et al. 2019

Preprint

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Purpose Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI. Materials and Methods 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66±12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40±16yo; retrospective from 2010-2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates. Results Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P=0.01) and apex (fitted reduction = 1.4 L/min; P=0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P=0.01). Conclusion A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced flow, particularly in the LV apex, relative to controls.

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“…Research by Wong et al . supports the finding that peak E-wave LV blood flow KE declines with age 19 , despite differences in study design to the present study. The current study is the first to compare 4D blood flow LV energetics with existing 2D standard mitral inflow metrics of diastolic function for their association to advancing age.…”

Section: Discussionsupporting

confidence: 89%

Impact of Age and Diastolic Function on Novel, 4D flow CMR Biomarkers of Left Ventricular Blood Flow Kinetic Energy

Crandon

Westenberg

Swoboda

et al. 2018

Sci Rep

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Two-dimensional (2D) methods of assessing mitral inflow velocities are pre-load dependent, limiting their reliability for evaluating diastolic function. Left ventricular (LV) blood flow kinetic energy (KE) derived from four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR) may offer improvements. It remains unclear whether 4D LV blood flow KE parameters are associated with physiological factors, such as age when compared to 2D mitral inflow velocities. Fifty-three healthy volunteers underwent standard CMR, plus 4D flow acquisition. LV blood flow KE parameters demonstrated good reproducibility with mean coefficient of variation of 6 ± 2% and an accuracy of 99% with a precision of 97%. The LV blood flow KEiEDV E/A ratio demonstrated good association to the 2D mitral inflow E/A ratio (r = 0.77, P < 0.01), with both decreasing progressively with advancing age (P < 0.01). Furthermore, peak E-wave KEiEDV and A-wave KEiEDV displayed a stronger association to age than the corresponding 2D metrics, peak E-wave and A-wave velocity (r = −0.51 vs −0.17 and r = 0.65 vs 0.46). Peak E-wave KEiEDV decreases whilst peak A-wave KEiEDV increases with advancing age. This study presents values for various LV blood flow KE parameters in health, as well as demonstrating that they show stronger and independent correlations to age than standard diastolic metrics.

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Age-related changes in intraventricular kinetic energy: a physiological or pathological adaptation?

Cited by 33 publications

References 41 publications

Reduced regional flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI

Reduced regional flow in the left ventricle after anterior acute myocardial infarction: a case control study using 4D flow MRI

Reduced flow in the left ventricular apex after anterior acute myocardial infarction: a case control study using 4D flow MRI

Impact of Age and Diastolic Function on Novel, 4D flow CMR Biomarkers of Left Ventricular Blood Flow Kinetic Energy

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