Age-Related Changes in Morphometric Parameters of Hippocampal Neurons in Humans

Shemyakov, S. E.; Nikolenko, V. N.; Sarkisyan, K. D.

doi:10.1007/s11055-017-0442-y

Cited by 3 publications

(1 citation statement)

References 7 publications

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“… 3 , 4 The hippocampus is a functional brain region involved in pattern recognition, emotion regulation, spatial learning, and memory. 5 Stress is an important biological reaction of the body when stimulated by various psychological, social, and environmental factors, which is now considered as one of the leading causes of depression. 6 Studies have found that long-term stress can lead to changes in the body’s neuroendocrine system and the immune system.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal miRNA-144 Modulates Depressive-Like Behaviors in Rats by Targeting PTP1B

Li¹,

Wang²,

Pan³

et al. 2021

NDT

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Background: Depression is the common mental disorder in the world. However, the pathophysiology mechanism underlying depression remains elusive. It has been reported that aberrant expression of miR-144 is closely related to depression. This study was to investigate whether and how miR-144 involves in depressive-like behaviors in a chronic unpredictable mild stress (CUMS) animal model. Methods: A rat model of CUMS was established, and qRT-PCR was performed to detect the expression of miR-144 in the hippocampus of a depressed rat. The lentiviral vector carried miR-144 (LV-miR-144) was injected into the hippocampus of the CUMS rat to investigate the effects of miR-144 on the behaviors and PTP1B/TrkB/BDNF signal transduction in the hippocampus of the rat. The interaction between miR-144 and PTP1B was investigated by biological analyses and dual-luciferase reporter assay. Results: The results showed that CUMS rats had typical depressive behaviors, and the expression of miR-144 in the hippocampus of CUMS rats was significantly lower than that of the control group. In addition, PTP1B protein expression was significantly up-regulated, while the expression of pTrkB and BDNF protein was significantly down-regulated in the hippocampus of CUMS rats. Moreover, PTP1B was a direct target of miR-144, and miR-144 could activate the downstream TrkB/BDNF signaling pathway by inhibiting the expression of PTP1B in primary hippocampus neurons. Conclusion: MiR-144 played an anti-depressive role in hippocampus dysfunction by inhibiting PTP1B and activating the TrkB/BDNF signaling pathway in the hippocampus of CUMS rats.

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Section: Introductionmentioning

confidence: 99%

Hippocampal miRNA-144 Modulates Depressive-Like Behaviors in Rats by Targeting PTP1B

Li¹,

Wang²,

Pan³

et al. 2021

NDT

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Morphological characteristics of the brain nervous tissue during aging

Magnaeva¹,

Gulevskaya²,

Anufriev³

et al. 2022

Arkh. patol.

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Pathogenetic mechanisms of mild traumatic brain injury in patients of different ages

Kurikeru,

Muravskiy,

Huk

2021

ECM

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This study was carried out to reveal the influence of mechanical energy, which triggers a whole cascade of pathological and compensatory processes of different depth and duration in the brain in traumatic brain injury (TBI). One of the most common consequences of TBI is impaired working memory – the ability to temporarily hold small pieces of information necessary for current mental activity. The aim of the work is to study the relationship between the TBI mechanism and the types of brain damage, as well as the consequences of trauma in patients of different ages. 95 case histories of patients with closed TBI were studied. All patients were treated in the Neurosurgical department of the Emergency hospital, Chernivtsi. Among them were 76 men and 19 women. The study found that TBI of patients in most cases was obtained as a result of traffic and others accidents. All patients had closed TBI. Contusion foci in all age groups were equally identified in the frontal, temporal and occipital lobes, less in the parietal lobe. The incidence of contusion increased slightly with increasing age of patients. In the presence of hemorrhages in patients, hemiparesis and liquor-hypertensive syndrome occurred. In men, TBI was more common than in women, and was expressed as moderate brain contusion, subacute and chronic compression of the brain. This TBI development was more common in young patients. It is promising to further study the nature of combined TBI in people of all ages and analyze the results of specialized neurosurgical care. Keywords: traumatic brain injury, neurosurgical care, liquor-hypertensive syndrome.

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Age-Related Changes in Morphometric Parameters of Hippocampal Neurons in Humans

Cited by 3 publications

References 7 publications

Hippocampal miRNA-144 Modulates Depressive-Like Behaviors in Rats by Targeting PTP1B

Hippocampal miRNA-144 Modulates Depressive-Like Behaviors in Rats by Targeting PTP1B

Morphological characteristics of the brain nervous tissue during aging

Pathogenetic mechanisms of mild traumatic brain injury in patients of different ages

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