Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline

Shur, Natalie F.; Creedon, L.; Skirrow, S. Z.; Atherton, Philip J.; Macdonald, Ian A.; Lund, Jonathan N.; Greenhaff, Paul L.

doi:10.1016/j.arr.2021.101344

Cited by 63 publications

(44 citation statements)

References 79 publications

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“…Muscular strength was included in this study to verify the impact of social isolation on the physical health of elderly. It is known that restrictions to the practice of phys-ical activity tend to affect muscular components and intensify physiological changes of aging [25].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Impact of Social Isolation on the Physical and Mental Health of Older Adults: A Follow-Up Study at the Apex of the COVID-19 Pandemic in Brazil

Bravalhieri

Rodrigues

Batiston

et al. 2022

Dement Geriatr Cogn Disord

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Introduction: The COVID-19 pandemic has affected people’s lives and caused changes in habits. The World Health Organization recommends social isolation as a way of minimizing the risk of contagion of the disease. Objective: The aim of the study was to assess the impact of social isolation due to COVID-19 pandemic on the physical and mental health of older adults and to investigate how anthropometric, functional, and clinical aspects are associated with this process. Methods: Fifty healthy older adults were followed-up during 5 months. The subjects had their physical and mental health assessed during social isolation (pre-vaccine situation) and after the opening of stores and activities in the municipality (post-vaccine situation). Physical evaluation was performed using the 30-s sit and stand test. Participants’ mental health was assessed with the Geriatric Depression Scale and the Loneliness Index. In this methodological design, muscle strength, depressive symptoms, and loneliness index were subject to pre-post analyses. In addition, these variables were included as outcomes in linear regression models. Participants’ anthropometric, functional, and clinical factors were included as predictors of the statistical model. Results: Participants’ scores at baseline were consistent with mild depressive symptoms and low loneliness. The muscle strength of the subjects was appropriate to their ages. After 5 months of social isolation, all variables declined, but with statistical significance only for depressive symptoms (p = 0.017, effect size of 0.11). Anthropometric, functional, and clinical factors explained 42.8% of depressive symptoms, 22.3% of loneliness, and 30.2% of muscle strength in the elderly. Discussion/Conclusion: Older adults presented baseline scores consistent with mild depressive symptoms and low loneliness. The muscular strength of the subjects was appropriate for their ages. After 5 months of social isolation, all variables declined. Anthropometric, functional, and clinical factors explained a substantial part of the depressive symptoms, loneliness, and muscular strength in the elderly. Health care professionals should be aware of performing a wide assessment in subjects’ lives to ensure better health status.

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Section: Discussion/conclusionmentioning

confidence: 99%

Impact of Social Isolation on the Physical and Mental Health of Older Adults: A Follow-Up Study at the Apex of the COVID-19 Pandemic in Brazil

Bravalhieri

Rodrigues

Batiston

et al. 2022

Dement Geriatr Cogn Disord

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“…is outcome was congruent with previous studies [21][22][23], in which older adults showed a more sedentary lifestyle. Age-related changes in muscle architecture and metabolism [39] may lead to physical inactivity, which is a concern with the aging society and the burden of KOA in Taiwan. Further studies are needed to develop an effective PA program to improve health and avoid adverse outcomes for older people, especially those with KOA.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Physical Activity of People with Knee Osteoarthritis in Southern Taiwan: A Multiple Logistic Regression Analysis

Hsu

Hsieh

Chiu

2022

International Journal of Clinical Practice

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Background. Physical activity (PA) is a basic and initiative conservative management for people with knee osteoarthritis (KOA). This study aimed to explore the potential indicators of PA levels in people with KOA. Methods. We designed a cross-sectional study where people with KOA were consecutively approached by the Orthopedic Outpatient Department in a hospital in southern Taiwan. People older than 50 years that could communicate and consent to the present study were enrolled. As a dependent variable, the Chinese version of the Physical Activity Scale for the Elderly (PASE-C) was used to assess the participant’s PA levels. Considering differences in sex, a PASE-C score cut-off point of 140 for men and 120 for women was used. Participants were then divided into “active” and “inactive” groups. We measured independent variables consisting of the demographic and clinical characteristics, such as comorbidities measured by the Charlson Comorbidity Index (CCI), depression status measured by the Geriatric Depression Scale-5, body mass index, KOA history (<5, 5–<10, and ≥10 years), knee pain (unilateral or bilateral), the severity of symptoms measured by the Western Ontario and McMaster Universities Osteoarthritis Index, and 6-meter preferred walking speed. Multiple logistic regression was performed to identify significant relationships between PA among people with KOA. Results. We analyzed a total of 188 people with KOA (56 men and 132 women) with a mean age of 69.4 ± 7.9 (range: 51 to 90 years). Approximately 72.9% (n = 137) were categorized as “inactive PA,” while 27.1% (n = 51) of participants were categorized as “active PA” (male: 32.1%; female: 25.0%). Multiple logistic regression showed a positive association of 6-meter preferred walking speed with active PA (OR: 7.08; 95% CI:1.14–44.13), whereas advanced age and comorbidity (CCI≥1 vs. CCI<1) were negatively associated with active PA with an OR (95% CI) score of 0.91 (0.86–0.97) and 0.37 (0.15–0.87), respectively. Conclusions. People with KOA require appropriate lifestyle management to increase PA. Walking speed may be an effective factor for predicting PA among people with KOA. Healthcare providers treating KOA patients should be aware of their PA levels, especially those at risk.

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“…Within sedentary individuals, YC had a better performance than SC probably attributable to a significantly higher muscle power, suggesting again that aging negatively affects muscle power [ 27 ]. In conclusion, both aging and sedentarism result in a decreased muscle power in the M1LH test, but lifelong training could be associated to a counterbalance of the effects of aging [ 28 , 29 , 30 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Aging and Fitness on Hopping Biomechanics

Sánchez-Trigo

Zange

Sies

et al. 2022

IJERPH

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Physical exercise promotes healthy aging and is associated with greater functionality and quality of life. Muscle strength and power are established factors in the ability to perform daily tasks and live independently. Stiffness, for mechanical reasons, is another important constituent of running performance and locomotion. This study aims to analyze the impact of age and training status on one-legged hopping biomechanics and to evaluate whether age-related power decline can be reduced with regular physical exercise. Forty-three male subjects were recruited according to their suitability for one of four groups (young athletes, senior athletes, young controls and senior controls) according to their age (young between 21 and 35, vs. older between 59 and 75) and training status (competing athletes vs. non-physically active). The impact of age and training status on one-legged hopping biomechanics were evaluated using the two-way analysis of variance (ANOVA) method. Significant differences among groups were found for hopping height (p < 0.05), ground contact time (p < 0.05), peak ground reaction force (p < 0.05) and peak power (p < 0.01). No differences among groups were found in ground-phase vertical displacement and vertical stiffness (p > 0.05). Young athletes and older non-physically active people achieved the best and worst performance, respectively. Interestingly, there were not any differences found between young non-physically active people and senior athletes, suggesting that chronic training can contribute to partly offset effects that are normally associated with aging.

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Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline

Cited by 63 publications

References 79 publications

Impact of Social Isolation on the Physical and Mental Health of Older Adults: A Follow-Up Study at the Apex of the COVID-19 Pandemic in Brazil

Impact of Social Isolation on the Physical and Mental Health of Older Adults: A Follow-Up Study at the Apex of the COVID-19 Pandemic in Brazil

Factors Affecting Physical Activity of People with Knee Osteoarthritis in Southern Taiwan: A Multiple Logistic Regression Analysis

Effects of Aging and Fitness on Hopping Biomechanics

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