Age-related changes in saccadic eye movements in healthy subjects and patients with Parkinson’s disease

Litvinova, A. S.; Ратманова, П. О.; Евина, Е И; Богданов, Р. Р.; Kunitsyna, A.; Напалков, Д. А.

doi:10.1134/s0362119711010117

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…While one study reported that the incidence of MSS increased significantly after the age of 60 (Litvinova et al, 2011), our results show that the incidence of MSS was positively and linearly correlated with age from 20 to 79 years old (Figure 3A), indicating that the incidence of MSS increases following natural degeneration. Conversely, a negative correlation was found between the incidence of MSS and age from childhood to young adulthood (Van Donkelaar et al, 2007), indicating that the incidence of MSS decreases following natural development.…”

Section: The Effects Of Age On the Incidences Of Multiple Step Saccad...contrasting

confidence: 58%

“…Since PD is the second most common neurodegenerative disease, understanding the general effect of aging on the incidence of MSS will provide important information for understanding the mechanisms of MSS in PD. Surprisingly, while seeking the relevant literature, we only found two papers that studied the effect of age on the incidence of MSS ( Van Donkelaar et al, 2007 ; Litvinova et al, 2011 ). While one study reported that the incidence of MSS gradually decreased following the development of the brain from childhood to young adulthood ( Van Donkelaar et al, 2007 ), another study reported that the incidence of MSS increased significantly after the age of 60 ( Litvinova et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

“…Surprisingly, while seeking the relevant literature, we only found two papers that studied the effect of age on the incidence of MSS ( Van Donkelaar et al, 2007 ; Litvinova et al, 2011 ). While one study reported that the incidence of MSS gradually decreased following the development of the brain from childhood to young adulthood ( Van Donkelaar et al, 2007 ), another study reported that the incidence of MSS increased significantly after the age of 60 ( Litvinova et al, 2011 ). However, there are some limitations in the second study due to the small number of healthy participants and the inclusion of CS as a part of MSS (see the following second paragraph for detail).…”

Section: Introductionmentioning

confidence: 99%

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The effects of age and sex on the incidence of multiple step saccades and corrective saccades

Zhang

2022

Front. Aging Neurosci.

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ObjectiveAlthough multiple step saccades (MSS) is occasionally observed in healthy subjects, it is more pronounced in patients with aging-related neurodegenerative diseases, particularly Parkinson’s disease (PD). Thus, MSS has been treated as a complementary biomarker for diagnosing PD. Despite the aforementioned knowledge, several questions remain unexplored: (1) How does aging affect MSS? (2) Is there a sex difference in MSS? (3) Are there differences in MSS between vertical and horizontal saccades? (4) Are MSS and corrective saccade (CS) the same behavior? (5) How do age and sex affect CS? The objectives of the present study are to address these questions.MethodFour hundred eighty healthy participants were recruited to perform a visually guided reactive saccade task. Participants were divided into six groups according to their ages. Each group consisted of 40 male and 40 female participants. Eye movements were recorded with infrared eye trackers.ResultsThe incidence of MSS increased as a function of age, whereas the incidence of CS first increased with age 20–49 and then decreased with age 50–79. The incidences of both MSS and CS did not show sex differences. The incidence of MSS in vertical saccades was significantly higher than that in horizontal saccades, and their difference increased with increasing age, whereas the incidence of CS showed a reversed pattern.ConclusionAge and saccadic direction affect the occurrences of MSS and CS differently, indicating that MSS and CS are different saccadic behaviors. In addition, measuring saccades could reliably reflect the function of human’s brain which is affected by aging.

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Section: The Effects Of Age On the Incidences Of Multiple Step Saccad...contrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of age and sex on the incidence of multiple step saccades and corrective saccades

Zhang

2022

Front. Aging Neurosci.

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“…To our knowledge, no difference has been reported in the statokinesigrams between 40 and 70 years old, either. Most changes in saccadic eye movement in healthy subjects occur after 60 years (38) and thus any age bias is expected to be minor.…”

Section: Discussionmentioning

confidence: 99%

Balance Impairment in Radiation Induced Leukoencephalopathy Patients Is Coupled With Altered Visual Attention in Natural Tasks

et al. 2019

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Background: Recent studies have shown that alterations in executive function and attention lead to balance control disturbances. One way of exploring the allocation of attention is to record eye movements. Most experimental data come from a free viewing of static scenes but additional information can be leveraged by recording eye movements during natural tasks. Here, we aimed to provide evidence of a correlation between impaired visual alteration in natural tasks and postural control in patients suffering from Radiation-Induced Leukoencephalopathy (RIL).Methods: The study subjects were nine healthy controls and 10 patients who were diagnosed with RIL at an early stage, with isolated dysexecutive syndrome without clinically detectable gait or posture impairment. We performed a balance evaluation and eye movement recording during an ecological task (reading a recipe while cooking). We calculated a postural score and oculomotor parameters already proposed in the literature. We performed a variable selection using an out-of-bag random permutation and a random forest regression algorithm to find: (i) if visual parameters can predict postural deficit and, (ii) which are the most important of them in this prediction. Results were validated using the leave-one-out cross-validation procedure.Results: Postural scores indeed were found significantly lower in patients with RIL than in healthy controls. Visual parameters were found able to predict the postural score of RIL patients with normalized root mean square error (RMSE) of 0.16. The present analysis showed that horizontal and vertical eye movements, as well as the average duration of the saccades and fixations influenced significantly the prediction of the postural score in RIL patients. While two patients with very low MATTIS-Attention sub score showed the lowest postural scores, no statistically significant relationship was found between the two outcomes.Conclusion: These results highlight the significant relationship between the severity of balance deficits and the visual characteristics in RIL patients. It seems that increased balance impairment is coupled with a reduced focusing capacity in ecological tasks. Balance and eye movement recordings during a natural task could be a useful aspect of multidimensional scoring of the dysexecutive syndrome.

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“…According to previous studies, SEM characteristics may indicate age-related changes in the nervous system [10,11]. In addition, in healthy adults, the latency of SEM increases significantly after the age of 60 years [12]. In addition, peak saccade velocity was significantly slower for amplitudes exceeding 20 degrees, and saccadic reaction times were prolonged in older adults [13].…”

Section: Introductionmentioning

confidence: 79%

Decreased Saccadic Eye Movement Speed Correlates with Dynamic Balance in Older Adults

Bae

2022

IJERPH

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This study aimed to determine the change in saccadic eye movement (SEM) speed according to age (young older; 65–72 years, middle older; 73–80 years, old older: over 81 years) in the elderly and identify the correlation between SEM speed and balance ability. We recruited 128 elderly individuals and measured their SEM speed and balance. The SEM speed was measured to allow the target to appear once every 2 s (0.5 Hz), twice per second (2 Hz), or thrice per second (3 Hz). The SEM performance time was 1 min with a washout period of 1 min. Balance ability was measured using the functional reach test (FRT), timed up-and-go test (TUG), and walking speed (WS). As age increased, FRT, TUG, and WS decreased and SEM speed was significantly decreased in old older than in young older adults at 3 HZ. In all participants, the 3 Hz SEM speed was significantly correlated with TUG and WS. Therefore, SEM speed may be inadequate or decreased in response to rapid external environmental stimuli and may be a factor that deteriorates the ability to balance in older adults.

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Age-related changes in saccadic eye movements in healthy subjects and patients with Parkinson’s disease

Cited by 7 publications

References 19 publications

The effects of age and sex on the incidence of multiple step saccades and corrective saccades

The effects of age and sex on the incidence of multiple step saccades and corrective saccades

Balance Impairment in Radiation Induced Leukoencephalopathy Patients Is Coupled With Altered Visual Attention in Natural Tasks

Decreased Saccadic Eye Movement Speed Correlates with Dynamic Balance in Older Adults

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