Age-related changes in sensitivity of rat urinary bladder to atonomic agents

Kolta, Malak G.; Wallace, Lane J.; Gerald, Michael C.

doi:10.1016/0047-6374(84)90043-5

Cited by 66 publications

(36 citation statements)

References 3 publications

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“…In accordance with the contraction study, the muscarinic receptor density (B max ) and its affinity (K d ) were not altered in the aged rat. In contrast to our present result, Kolta et al (1984) reported the age-related increase in muscarinic receptor of 7, 17 and 29 month-old-rats [6]. On the other hand, Hayes et al (1983) reported no age-related changes in muscarinic receptor of Sprague-Dawley rats [17].…”

Section: Changes In Muscarinic Receptors In Aged Body and Trigonecontrasting

confidence: 55%

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Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Aita¹,

Ishihata²,

Yamada³

et al. 2012

Health

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The urinary bladder is innervated and functionally regulated by the autonomic nervous system. In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. The binding characteristics of [ 3 H]quinuclidinyl benzilate (QNB) to muscarinic cholinoceptors were compared in young and aged bladder. Bladders from young (2 -3 month-old) and aged (27 month-old) male Fischer 344 rats were isolated, cut into strips and mounted in the organ bath, then the developed tension was recorded. Histologically, the aged bladder did not show pathologic changes such as inflammation and hypertrophy. Carbachol-induced contraction in aged rat bladder was identical to that obtained in young rat. In the receptor binding assay, [ 3 H]QNB maximal binding capacity and Kd value were not significantly changed in aged bladder. In contrast, a selective α-adrenergic agonist phenylephrine, elicited greater contractions both in the aged body and trigone than those in young rats. The augmentation of α-adrenoceptor-mediated contractions in aged bladder may induce urinary dysfunction such as voiding difficulty.

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Section: Changes In Muscarinic Receptors In Aged Body and Trigonecontrasting

confidence: 55%

“…Several reports indicated that both alpha-adrenergic receptor and muscarinic receptor existed not only in bladder body but also in trigone [6][7][8]. However, there are no confidential results whether α-adrenergic as well as muscarinic receptors play a role in age-related functional changes of urinary bladder.…”

Section: Discussionmentioning

confidence: 88%

Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Aita¹,

Ishihata²,

Yamada³

et al. 2012

Health

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“…There is a signifi cant variation in the reported results. Some studies show age-dependent raises (32,33) or reduction in ACh-induced responses (34), whereas others report no changes in carbachol stimulated contract ion (35,36). Our data showed that Ovx impairs Ach-evoked contractile response and estrogen treatment recovered the detrusor contraction by its effect on the oxidative stress and CF\SM ratio.…”

Section: Discussionsupporting

confidence: 55%

Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rat

Tasdemir¹,

Taşdemir²,

Vardı³

et al. 2014

BLL

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:Objective: The incidence of urinary bladder disturbances and renal structural changes and functional decline are found to increase with age. Methods: We investigated the effect of melatonin treatment in addition to estrogen replacement therapy in pinealectomized (Px) and ovariectomized (Ovx) rats. 56 female Wistar rats were divided into seven groups, each containing eight animals: Sham, (Ovx), (Px), Px+Ovx, Px+Ovx receiving estrogen (Px+Ovx+E), Px+Ovx receiving melatonin (Px+Ovx+M) and Px+Ovx estrogen and melatonin supplemented (Px+Ovx+EM) group (EM group). We evaluated reduced glutathione (GSH) levels and malondialdehyde (MDA) levels. The mean collagen fi ber (CF)/smooth muscle (SM) ratio in the bladder wall and structure of the kidney were examined histolologically. We aleso recorded response of the bladder contractility to acetylcholine (Ach). Results: Px and Ovx groups showed statistically signifi cant reductions of antioxidant defenses, impaired Achevoked contraction, histological changes compared with the control group. Also, these changes were prominent in Px+Ovx group compared with all other groups. Both estrogen and melatonin reversed these changes however best restoration was observed in the EM group. Conclusions: Px performed in addition to Ovx led to a distinct increase in oxidative damage in bladder and renal tissue and deteriorate of the detrussor function. Either estradiol or melatonin replacement alone or in combination prevents signifi cant alterations of tissue histology and bladder contractility following Ovx and Px. Thus, combination treatment appears to be the best method to restore both contractility and histomorphology of bladder and kidney tissues after Ovx and Px (Tab. 3, Fig. 4, Ref. 44). Text in PDF www.elis.sk.

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“…Surprisingly, there have been only a few reports that age affects mus carinic cholinergic receptors in the rat prostate. Three reports (29)(30)(31) have examined muscarinic receptors in the aging rat urinary bladder. Two showed an increase (29,30) in the density of receptors, while the other showed no change (31).…”

Section: Discussionmentioning

confidence: 99%

“…Three reports (29)(30)(31) have examined muscarinic receptors in the aging rat urinary bladder. Two showed an increase (29,30) in the density of receptors, while the other showed no change (31). However, these discrepancies might be explained by possible differences in the nature of the tissue samples and/or rat strain.…”

Section: Discussionmentioning

confidence: 99%

Potentiation of β-Adrenergic Function by Saiboku-To and Bakumondo-To in Canine Bronchial Smooth Muscle

Yazawa

Honda

1993

Japanese Journal of Pharmacology

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Age-related changes in sensitivity of rat urinary bladder to atonomic agents

Cited by 66 publications

References 3 publications

Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rat

Potentiation of β-Adrenergic Function by Saiboku-To and Bakumondo-To in Canine Bronchial Smooth Muscle

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Age-related changes in sensitivity of rat urinary bladder to atonomic agents

Cited by 66 publications

References 3 publications

Selective changes in the &lt;i&gt;α&lt;/i&gt;-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Selective changes in the &lt;i&gt;α&lt;/i&gt;-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Combined usage of estrogen and melatonin restores bladder contractility and reduces kidney and bladder damage in ovariectomized and pinealectomized rat

Potentiation of β-Adrenergic Function by Saiboku-To and Bakumondo-To in Canine Bronchial Smooth Muscle

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Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder

Selective changes in the <i>α</i>-adrenoceptor-mediated contraction in the senescent rat urinary bladder