Age-Related Changes in Skeletal Muscle Oxygen Utilization

Salvatore, Sabrina S.; Zelenski, Kyle N.; Perkins, Ryan

doi:10.3390/jfmk7040087

Cited by 5 publications

(3 citation statements)

References 141 publications

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“…This contradicts the majority of existent evidence, whereby associations between muscle mass and CRF have consistently been demonstrated in both healthy and clinical cohorts. 6,28,29 Given the role of skeletal muscle in oxygen utilization, 30 the mechanistic basis of this association is fairly clear. One potential explanation for the lack of relationship reported herein may be the method used to assess muscle size.…”

Section: Discussionmentioning

confidence: 99%

Exploring the utility of bedside tests for predicting cardiorespiratory fitness in older adults

Carrick,

Doleman,

Wall

et al. 2023

Aging Medicine

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ObjectivesCardiorespiratory fitness (CRF) declines with advancing and has also, independent of age, been shown to be predictive of all‐cause mortality, morbidity, and poor clinical outcomes. In relation to the older patient, there is a particular wealth of evidence highlighting the relationship between low CRF and poor surgical outcomes. Cardiopulmonary exercise testing (CPET) is accepted as the gold‐standard measure of CRF. However, this form of assessment has significant personnel and equipment demands and is not feasible for those with certain age‐associated physical limitations, including joint and cardiovascular comorbidities. As such, alternative ways to assess the CRF of older patients are very much needed.MethodsSixty‐four participants (45% female) with a median age of 74 (65–90) years were recruited to this study via community‐based advertisements. All participants completed three tests of physical function: (1) a step‐box test; (2) handgrip strength dynamometry; and (3) a CPET on a cycle ergometer; and also had their muscle architecture (vastus lateralis) assessed by B‐mode ultrasonography to provide measures of muscle thickness, pennation angle, and fascicle length. Multivariate linear regression was then used to ascertain bedside predictors of CPET parameters from the alternative measures of physical function and demographic (age, gender, body mass index (BMI)) data.ResultsThere was no significant association between ultrasound‐assessed parameters of muscle architecture and measures of CRF. VO2peak was predicted to some extent from fast step time during the step‐box test, gender, and BMI, leading to a model that achieved an R2 of 0.40 (p < 0.001). Further, in aiming to develop a model with minimal assessment demands (i.e., using handgrip dynamometry rather than the step‐box test), replacing fast step time with non‐dominant HGS led to a model which achieved an R2 of 0.36 (p < 0.001). Non‐dominant handgrip strength combined with the step‐box test parameter of fast step time and BMI delivered the most predictive model for VO2peak with an R2 of 0.45 (p < 0.001).ConclusionsOur findings show that simple‐to‐ascertain patient characteristics and bedside assessments of physical function are able to predict CPET‐derived CRF. Combined with gender and BMI, both handgrip strength and fast step time during a step‐box test were predictive for VO2peak. Future work should apply this model to a clinical population to determine its utility in this setting and to explore if simple bedside tests are predictive of important clinical outcomes in older adults (i.e., post‐surgical complications).

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Section: Discussionmentioning

confidence: 99%

Exploring the utility of bedside tests for predicting cardiorespiratory fitness in older adults

Carrick,

Doleman,

Wall

et al. 2023

Aging Medicine

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“…Recommendations to reduce variability and errors in data collection, analysis and interpretation were also provided. Salvatore et al [ 5 ] summarized the effects of aging in healthy individuals and muscle O 2 utilization; aging reduces SmO 2 at rest, and during submaximal and maximal exercise, and extends the timeframe for restoration of SmO 2 following exercise. In 2021, Cornelis et al [ 6 ], summarizing the results of 11 clinical trials on the impact of exercise therapy on lower limb SmO 2 evaluated by NIRS in patients with lower-extremity artery disease, showed that exercise training improved the de-oxygenation and re-oxygenation patterns.…”

Section: Introductionmentioning

confidence: 99%

Muscle Oximetry in Sports Science: An Updated Systematic Review

Perrey,

Quaresima,

Ferrari

2024

Sports Med

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Background In the last 5 years since our last systematic review, a significant number of articles have been published on the technical aspects of muscle near-infrared spectroscopy (NIRS), the interpretation of the signals and the benefits of using the NIRS technique to measure the physiological status of muscles and to determine the workload of working muscles. Objectives Considering the consistent number of studies on the application of muscle oximetry in sports science published over the last 5 years, the objectives of this updated systematic review were to highlight the applications of muscle oximetry in the assessment of skeletal muscle oxidative performance in sports activities and to emphasize how this technology has been applied to exercise and training over the last 5 years. In addition, some recent instrumental developments will be briefly summarized. Methods Preferred Reporting Items for Systematic Reviews guidelines were followed in a systematic fashion to search, appraise and synthesize existing literature on this topic. Electronic databases such as Scopus, MEDLINE/PubMed and SPORTDiscus were searched from March 2017 up to March 2023. Potential inclusions were screened against eligibility criteria relating to recreationally trained to elite athletes, with or without training programmes, who must have assessed physiological variables monitored by commercial oximeters or NIRS instrumentation. Results Of the identified records, 191 studies regrouping 3435 participants, met the eligibility criteria. This systematic review highlighted a number of key findings in 37 domains of sport activities. Overall, NIRS information can be used as a meaningful marker of skeletal muscle oxidative capacity and can become one of the primary monitoring tools in practice in conjunction with, or in comparison with, heart rate or mechanical power indices in diverse exercise contexts and across different types of training and interventions. Conclusions Although the feasibility and success of the use of muscle oximetry in sports science is well documented, there is still a need for further instrumental development to overcome current instrumental limitations. Longitudinal studies are urgently needed to strengthen the benefits of using muscle oximetry in sports science.

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“…Prolonged and repetitive exposures to these risk factors may have biomechanical and physiological impacts such as restriction of the blood circulation to body parts and consequently reduction of supplied oxygen to the muscles [18]- [20]. Muscle and oxygen consumption in human skeletal muscles [21], [22]. This can lead to faster rate of fatigue, and prolonged physiological stresses may even lead to tissue damage and eventually musculoskeletal symptoms will start to emerge [23]- [25].…”

Section: Introductionmentioning

confidence: 99%

Effect of computer workstation set-ups on muscle oxygen saturation and perceived fatigue

Radin Umar,

Yin,

Ahmad

2024

IJPHS

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Multiple literatures show evidences of how office workstation set-ups can influence muscle activities. However, the relationship between the postural adoption due to workstation setup and its effect to muscle oxygen saturation among office workers is unclear. The aim of this study was to investigate trends of muscle oxygen saturation and perceived fatigue ratings between different upper limbs posture variations among representative computer users. A repeated measure experiment was conducted on 15 participants to compare the muscle oxygen saturation and perceived fatigue ratings between four different office work posture variations. Parametric and non-parametric statistical analyses were conducted to analyze significant differences on the dependent parameters. Data analysis showed statistically significant trends (p≤0.050) of lower muscle oxygen saturation in workstation set-ups in which participants were adopting raised shoulder and extended arm positions. In addition, the findings revealed that the perceived fatigue ratings on the shoulder, upper arm and lower arm are the lowest (p≤0.050) in workstation condition where subject can adopt neutral postures. The results highlight the effect of good office workstation setup and work postures to individual muscle oxygen saturation and fatigue levels.

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Age-Related Changes in Skeletal Muscle Oxygen Utilization

Cited by 5 publications

References 141 publications

Exploring the utility of bedside tests for predicting cardiorespiratory fitness in older adults

Exploring the utility of bedside tests for predicting cardiorespiratory fitness in older adults

Muscle Oximetry in Sports Science: An Updated Systematic Review

Effect of computer workstation set-ups on muscle oxygen saturation and perceived fatigue

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