Age-related changes in sleep in inbred mice are genotype dependent

Hasan, Sibah; Dauvilliers, Yves; Mongrain, Valérie; Franken, Paul; Tafti, Mehdi

doi:10.1016/j.neurobiolaging.2010.05.010

Cited by 84 publications

(108 citation statements)

References 65 publications

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“…This is very similar to the effects of age on sleep in rodents (Welsh et al 1986;Stone 1989;Hasan et al 2012;Wimmer et al 2013). It has been suggested that these changes in sleep contribute to age-related cognitive decline, including deficits in the consolidation of episodic, hippocampusdependent memories (Pace-Schott and Spencer 2014).…”

Section: Sleep Deprivation In Aged Animals Causes Memory Impairments supporting

confidence: 69%

“…In contrast, young and old mice both showed clear deficits in memory due to acute post-training SD. Although old mice tend to have reductions in sleep compared with young mice, they still obtain substantial amounts of sleep, whereas gentle handling SD has been shown to be highly effective at eliminating all sleep during the SD period (Hasan et al 2012). Consistent with this view, a study in humans found that episodic memory in both young and old subjects was better preserved across a period of sleep than a period of wakefulness, demonstrating that the sleep older people obtain is still beneficial for memory (Aly and Moscovitch 2010).…”

Section: Sleep Deprivation In Aged Animals Causes Memory Impairments mentioning

confidence: 99%

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Effects of sleep deprivation and aging on long-term and remote memory in mice

et al. 2015

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Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a month after training, sleep-deprived and control aged animals performed similarly, primarily due to remote memory decay in the control aged animals. Gene expression analysis supported the finding that SD has similar effects on the hippocampus in young and aged mice.

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Section: Sleep Deprivation In Aged Animals Causes Memory Impairments supporting

confidence: 69%

Section: Sleep Deprivation In Aged Animals Causes Memory Impairments mentioning

confidence: 99%

Effects of sleep deprivation and aging on long-term and remote memory in mice

et al. 2015

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“…This maturation of sleep characteristics as an organism develops from embryo to mature adult is referred to as sleep ontogeny or ontogenetic sleep changes. Similar trends, where the amount of total sleep, or vertebrate REM sleep, is highest early in development, have been observed in mammals, fish, birds, insects, and nematodes (Jouvet-Mounier et al 1970;McGinty et al 1977;Szymczak 1987;Shaw et al 2000;Kirov and Moyanova 2002;Paredes et al 2006;Raizen et al 2008;Hasan et al 2012;Todd et al 2012;Sorribes 2013). These findings led to the hypothesis that during early life, REM sleep and invertebrate sleep may play an important role in the development of the nervous system, by establishing a period of globally heightened plasticity and/ or providing endogenous, specialized activity in certain neural circuits (O'Donovan 1999;Blumberg 2008, 2010;Blumberg et al 2013;Corner 2013).…”

supporting

confidence: 61%

“…There are many arguments in support of the universality of sleep, but conservation of ontogenetic sleep changes with an active role in the developing nervous system is emerging as one of the strongest (Roffwarg et al 1966;Jouvet-Mounier et al 1970;McGinty et al 1977;Shaw et al 2000;Kirov and Moyanova 2002;Raizen et al 2008;Hasan et al 2012;Todd et al 2012;Sorribes 2013;Kayser et al 2014). The observation that sleep amount is highest during developmental periods across species has led to extensive and ongoing explorations of the ontogenetic hypothesis, suggesting that sleep promotes normal brain development by providing necessary endogenous activity (Roffwarg et al 1966;Jouvet-Mounier et al 1970;Oksenberg et al 1996;Shaffery et al 1999;Frank 2011;Blumberg et al 2013;Kayser et al 2014;Tononi and Cirelli 2014).…”

Section: A Link Between Development and The Ubiquity Of Sleep?mentioning

confidence: 99%

Sleep and Development in Genetically Tractable Model Organisms

Kayser

Biron

2016

Genetics

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Sleep is widely recognized as essential, but without a clear singular function. Inadequate sleep impairs cognition, metabolism, immune function, and many other processes. Work in genetic model systems has greatly expanded our understanding of basic sleep neurobiology as well as introduced new concepts for why we sleep. Among these is an idea with its roots in human work nearly 50 years old: sleep in early life is crucial for normal brain maturation. Nearly all known species that sleep do so more while immature, and this increased sleep coincides with a period of exuberant synaptogenesis and massive neural circuit remodeling. Adequate sleep also appears critical for normal neurodevelopmental progression. This article describes recent findings regarding molecular and circuit mechanisms of sleep, with a focus on development and the insights garnered from models amenable to detailed genetic analyses.

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“…In addition, dementia, sleep complaints, and sleep-related problems are known to increase with age (Wolkove et al 2007a, b;Bastos Leite et al 2004;Plassman et al 2007;Wu and Swaab 2007). Although there is sufficient evidence from humans and experimental animals on the association between sleep disorders and dementia, these topics have not yet been explored in the very elderly population (Rose et al 2010;Riegel and Weaver 2009;Yu et al 2009;Haimov et al 2008;Benito-León et al 2009;Hasan et al 2012). Therefore, it is important to clarify the association between sleep disorders and dementia in this age group.…”

Section: Introductionmentioning

confidence: 99%

Association of sleep quality and dementia among long-lived Chinese older adults

Yue

Huang

Wang

et al. 2012

AGE

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In this study, we examined the existence of relationship between sleep quality and dementia in subjects aged 90 years and above. The sample included 216 men and 444 women. Dementia and sleep quality were measured with 30-item mini-mental state examination (MMSE) and the Pittsburgh sleep quality index, respectively. Subjects with dementia had higher sleep quality score (7.83 ± 2.15 vs. 5.22 ± 2.49; P < 0.0001), longer sleep latency (50.97 ± 21.33 vs. 37.61 ± 12.53; P < 0.0001), and a lower sleep efficiency percentage (73.95 ± 8.783 vs. 81.32 ± 10.21; P < 0.0001) and more likely to report poor sleep quality (25.42 vs.17.13 %; P 0 0.035). Subjects with poor sleep quality had significantly lower MMSE scores (P 0 0.007) and higher prevalence of dementia (P 0 0.042). Multiple logistic regressions were performed by adjusting clinical factors that are thought to be associated with dementia or sleep quality. We found that poor sleep quality was a risk factor for dementia (unadjusted odds ratio (OR) 1.719, 95 % confidence interval (CI) 1.138-2.597; adjusted OR 1.759, 95 % CI 1.012-3.057). There was no significant difference in MMSE scores (11.25 ± 3.40, 16.26 ± 5.14, and 15.43 ± 5.51; P 0 0.105) among participants with daily average sleep durations of <5, 5-9, and >9 h, respectively. Among Chinese nonagenarians and centenarians, dementia was correlated with poor sleep quality, longer sleep latency, and lower sleep efficiency percentage.

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Age-related changes in sleep in inbred mice are genotype dependent

Cited by 84 publications

References 65 publications

Effects of sleep deprivation and aging on long-term and remote memory in mice

Effects of sleep deprivation and aging on long-term and remote memory in mice

Sleep and Development in Genetically Tractable Model Organisms

Association of sleep quality and dementia among long-lived Chinese older adults

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