Age-related changes in the cytoarchitectonics of the human sensorimotor cortex

Шумейко, Н С

doi:10.1007/bf02464785

Cited by 4 publications

(3 citation statements)

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“…MPH is being prescribed to increasing numbers of children in the United States and Canada, as well as for longer treatment durations, often extending from childhood into adolescence (Klein, 1995;Minde, 1998;Solanto, 1998;Spencer et al, 1996). Neural development extends beyond adolescence into adulthood, with neural growth and differentiation continuing until 20 to 25 years of age (Benes, 1998;Giedd, 1999;Hockfield & Lombroso, 1998;Shumeiko, 1998). While there is considerable research on the neural and behavioral effects of in utero exposure to drugs (Dominguez, Vila-Coro, Slopis, & Bohan, 1991;Leonard, 1982;Loebstein & Koren, 1997), there is little research on the developmental effects of chronic childhood and adolescent psychopharmacotherapy (Carrey & Dursun, 1997;Vitiello, 1998).…”

Section: Introductionmentioning

confidence: 98%

Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice

McFadyen

Brown

Carrey³

2002

Developmental Psychobiology

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Methylphenidate hydrochloride (Ritalin, MPH) is frequently prescribed as a treatment for children with attention deficit hyperactivity disorder (ADHD), yet little research has been conducted to determine its potential long-term neurobehavioral effects. We assessed the effects of subchronic MPH administration (2.5, 5, 10, 20, 40, or 80 mg/kg) on male CD-1 mice treated from 26 to 32 days of age. When tested at 33 days of age in the open field and elevated plus maze, there were no significant differences in spontaneous locomotion, exploration, or fear- and anxiety-related behaviors. Testing from 34 to 37 days of age in a water maze task revealed no significant effects of any dose of MPH on learning in this simple paradigm. While it is difficult to extrapolate directly from these results to clinical effects in humans, our results indicate that preexposure of mice to MPH late in the postnatal developmental period does not appear to alter later behavior. We are currently conducting additional studies to further probe the potential effects of MPH administration during development and to examine various contributing factors including stage of development, duration of MPH administration, complexity of the task used to assess behavioral changes, and type of cognitive process being analyzed (attention, nonspatial working memory, etc.).

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Section: Introductionmentioning

confidence: 98%

Subchronic methylphenidate administration has no effect on locomotion, emotional behavior, or water maze learning in prepubertal mice

McFadyen

Brown

Carrey³

2002

Developmental Psychobiology

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“…However, the drugs that are used for treating psychiatric disorders in childhood and adolescence are designed primarily for adult patients. Neural development in children and adolescents is not yet complete, with neural growth and differentiation continuing up to 20 to 25 years of age (Benes, 1998;Giedd, 1999;Hock®eld & Lombroso, 1998;Shumeiko, 1998). The modulation of normal growth and neurochemical activity by childhood pharmacotherapy has the potential to lead to permanent organizational changes in the brain (Castner & Goldman-Rakic, 1999).…”

mentioning

confidence: 99%

Effects of chronic and acute methylphenidate hydrochloride (ritalin) administration on locomotor activity, ultrasonic vocalizations, and neuromotor development in 3‐ to 11‐day‐old CD‐1 mouse pups

Penner

McFadyen

Carrey

et al. 2001

Developmental Psychobiology

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The present study examined the effects of chronic and acute treatment with methylphenidate hydrochloride (Ritalin) on isolation-induced ultrasonic vocalizations, spontaneous locomotor activity, and neuromotor coordination in 3- to 11-day-old CD-1 mouse pups. In Experiment 1, 3- to 11-day-old pups received daily injections of saline, 5 mg/kg or 20 mg/kg of methylphenidate hydrochloride, or no injection and were tested on postnatal Days 3, 5, 7, 9, and 11. Both doses of methylphenidate resulted in significant increases in locomotor activity at all ages, but had no significant effect on body weight, neuromotor development, or emission of ultrasonic vocalizations. In Experiment 2, pups were given a single dose of methylphenidate (5 or 20 mg/kg), saline, or no injection on one of postnatal Days 5, 7, 9, or 11. This acute methylphenidate treatment increased locomotor activity, but had no significant effects on ultrasonic vocalizations or neuromotor coordination. These results indicate that short-term, chronic methylphenidate treatment elevates locomotor responses, but has no immediate effects on anxietylike responses or on the development of neuromotor behavior of CD-1 mice in the first 11 days of life.

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“…It is important to note that the Brodmann classification is based on adult brains and so were anatomically and neurophysiologically fully d e v e l o p e d . I t h a s b e e n s h o w n t h a t t h e cytoarchitecture of the sensorimotor cortex is subject to considerable modifications from birth (or even before) until the age of 20 (Shumeiko, 1998). Today, it is not clear how the cytoarchitecture of the cortex depends on its functional development.…”

Section: Anatomical Organization Of the Primary Areasmentioning

confidence: 99%