Age-related changes in the mechanics of the aorta and pulmonary artery of man.

Gozna, E. R.; Marble, A. E.; Shaw, Aidan; Jf, Holland

doi:10.1152/jappl.1974.36.4.407

Cited by 120 publications

(39 citation statements)

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“…23a accounts for the total content of elastin, i.e., both the undamaged and damaged parts. If we make use of the damage parameter of elastin (D), we can obtain f elast,eff as follows: ( 24) felast,eff is then substituted into constitutive Eq. 11 to derive the stress born by the undamaged part of elastin.…”

Section: Geometric Remodeling Induced By Augmented Pm and Elastin Framentioning

confidence: 99%

A constituent-based model of age-related changes in conduit arteries

Tsamis

Rachev

Stergiopulos

2011

American Journal of Physiology-Heart and Circulatory Physiology

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Tsamis A, Rachev A, Stergiopulos N. A constituent-based model of age-related changes in conduit arteries. Am J Physiol Heart Circ Physiol 301: H1286 -H1301, 2011. First published July 1, 2011; doi:10.1152/ajpheart.00570.2010.-In the present report, a constituent-based theoretical model of age-related changes in geometry and mechanical properties of conduit arteries is proposed. The model was based on the premise that given the time course of the load on an artery and the accumulation of advanced glycation end-products in the arterial tissue, the initial geometric dimensions and properties of the arterial tissue can be predicted by a solution of a boundary value problem for the governing equations that follow from finite elasticity, structure-based constitutive modeling within the constrained mixture theory, continuum damage theory, and global growth approach for stress-induced structure-based remodeling. An illustrative example of the age-related changes in geometry, structure, composition, and mechanical properties of a human thoracic aorta is considered. Model predictions were in good qualitative agreement with available experimental data in the literature. Limitations and perspectives for refining the model are discussed. arterial remodeling; vascular mechanics; elastin fatigue damage; collagen cross-linking AGING AFFECTS THE MECHANICAL FUNCTION of human conduit arteries such as the aorta, the iliac arteries, and the carotid arteries. It manifests as a change in the vessel geometry and material properties of the vascular tissue, accompanied by alterations in loading conditions. Geometric and structural alterations in the tissue of conduit vessels with progressing age cause a decrease in the total arterial compliance (66), which, in turn, leads to an increase in pulse pressure. The increase in pulse pressure has been shown to be the strongest predictor for cardiovascular mortality, for it augments the mechanical load on the left ventricle (9). Furthermore, the decrease in diastolic pressure observed in late middle age, which reduces the coronary arterial perfusion, raises the demands on the left ventricle (25).Geometric changes observed in aging are associated with an increase in arterial volume (7) characterized by increased lumen area (63) and wall thickening (43) and decreased axial stretch associated with loss in longitudinal stiffness (65). An increase in the opening angle has been observed, which was obtained after residual stress was relieved in an isolated arterial ring by a radial cut (54). Simultaneously, the content of collagen increases and the number of smooth muscle (SM) cells decreases (55). Furthermore, mean aortic pressure gradually increases with advanced age (27). The interrelation among the aforementioned processes is unknown. Additionally, the stiffness of the elastin structure gradually increases with advanced age due to a nonatherosclerotic mineralization mechanism called the medial elastocalcinosis (MEC), during which calcium salts bind to the elastin of the aortic media (15). Also, ela...

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Section: Geometric Remodeling Induced By Augmented Pm and Elastin Framentioning

confidence: 99%

A constituent-based model of age-related changes in conduit arteries

Tsamis

Rachev

Stergiopulos

2011

American Journal of Physiology-Heart and Circulatory Physiology

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“…[1][2][3][4][5] Stiffness represents the fundamental mechanical property of the large arteries responsible for the non-resistive component of left ventricular load and of vascular performance during diastole. Stiffness is translated to its functional effect, or compliance, via geometric factors.…”

Section: Introductionmentioning

confidence: 99%

The effect of age on vascular compliance in man: which are the appropriate measures?

et al. 1999

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“…They have the disadvantage of introducing a restraint on the vessel wall. Devices which do not affect the vessel wall are a photoelectrical apparatus, used only in vitro [21], X-ray angiography [2,6,14,16,22], intravascular ultrasound (IVUS) [29,30] and ultrasound wall-tracking techniques [8]. Angiography, IVUS and ultrasound walltracking techniques are expensive and the first two require labour-intensive analyses.…”

Section: Introductionmentioning

confidence: 99%

Determination of the mean cross-sectional area of the thoracic aorta using a double indicator dilution technique

Kornet

Jansen

Gussenhoven

et al. 1996

Pflügers Arch — Eur J Physiol

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A double indicator dilution technique for determining the mean cross-sectional area (CSA) of a blood vessel in vivo is presented. Analogous to the thermodilution method, dilution of hypertonic saline was measured by an electrical conductance technique. Because the change in conductance rather than absolute conductance was used to calculate CSA, pulsatile changes in shear rate of blood and conductance of surrounding tissues had no effect on the data. To calculate CSA from an ion mass balance, cardiac output was needed and estimated from the thermodilution curve using the same "cold" (hypertonic) saline injection. The mean CSA, obtained from this double indicator dilution method (CSA GD), was compared with the CSA obtained from the intravascular ultrasound method (IVUS) in 44 paired observations in six piglets. The regression line is close to the line of identity (CSAGD = -1.83 + 1.06 -CSAivus, r = 0.96). The difference between both CSAs was independent of the diameter of the vessel, on average -0.99 mm 2 + 2.64 mm2 (mean CSAGD = 46.84 ± 8.21 mm 2 , mean CSA,vus = 47.82 ± 9.08 mm 2) and not significant. The results show that the double indicator dilution method is a reliable technique for estimating the CSA of blood vessels in vivo.

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Age-related changes in the mechanics of the aorta and pulmonary artery of man.

Cited by 120 publications

References 0 publications

A constituent-based model of age-related changes in conduit arteries

A constituent-based model of age-related changes in conduit arteries

The effect of age on vascular compliance in man: which are the appropriate measures?

Determination of the mean cross-sectional area of the thoracic aorta using a double indicator dilution technique

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