Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial

Przemska-Kosicka, Agnieszka; Childs, Caroline E.; Maidens, Catherine; Dong, Honglin; Todd, Susan; Gosney, Margot; Tuohy, Kieran; Yaqoob, Parveen

doi:10.3389/fimmu.2018.00591

Cited by 40 publications

(28 citation statements)

References 58 publications

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“…In addition, neither time (p=0.97) nor treatment group (mean vaccine: 6.50% (95% CI: 5.34%, 7.91%); mean placebo: 5.51% (95% CI: 4.51%, 6.74%), p=0.24) were independently associated with CD56 dim cell counts. For CD56 bright cell counts, time modified the effect of placebo and vaccine groups (p=0.01); wherein CD56 bright count increased by a factor of 1.25 (95% CI: 1.07, 1.46, p=0.01) in the vaccine group but the change in the placebo group was not statistically significant (Table 2), which is consistent with other vaccine studies (Berthoud et al, 2009;Scott-Algara et al, 2010;Przemska-Kosicka et al, 2018).…”

Section: Minimal Variation In Total Nk-cell Frequencies Over Timesupporting

confidence: 86%

Dynamic changes in natural killer cell subset frequencies in the absence of cytomegalovirus infection

Gyurova

Schlums

Sucharew

et al. 2019

Preprint

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Individuals lacking functional natural killer (NK) cells suffer severe, recurrent infections with cytomegalovirus (CMV), highlighting the critical role of NK cells in antiviral defense. Therefore, ongoing attempts to develop an efficacious vaccine to prevent CMV infection should potentially aim to elicit NK-cell antiviral responses as an accessory to conventional T-and B-cell based approaches. In this regard, CMV infection provokes marked phenotypic and functional differentiation of the NK-cell compartment, including development of adaptive NK cells that exhibit enhanced antiviral activity. We examined longitudinal blood samples collected from 40 CMV-seronegative adolescents to ascertain whether a CMV glycoprotein B (gB) vaccine in the absence of CMV infection can stimulate differentiation or expansion of CMV-associated subsets of NK cells. Study participants uniformly lacked the CMV-dependent NKG2C + subset of NK cells, suggesting that an adjuvanted CMV gB vaccine alone is an inadequate stimulus for sustained expansion of these cells. In contrast, we observed unexpected dynamic fluctuations in the frequency of NK cells lacking FcR, EAT-2, and SYK, which were independent of vaccination or CMV infection. Whereas FcR neg NK cells in CMV infection are reported to express increased levels of the maturation marker CD57, the FcR neg NK cells observed in our CMV-negative vaccine cohort express less CD57 than their FcR + counterparts. The FcR neg NK cells in CMV-negative individuals were also functionally distinct from this subset in CMV infection, exhibiting comparable IFN- production and degranulation as FcR + NK cells in response to cytokine or antibody-dependent stimuli. These results suggest that frequencies of some NK cell subsets may increase in response to unknown environmental or inflammatory cues distinct from that which occurs after CMV infection. Greater understanding of the nature of the signals driving CMVindependent accumulation of these subsets should permit development of mechanisms to facilitate vaccine-driven expansion of CMV-reactive NK cells.Vaccine | HCMV | Innate lymphoid cell | NK cell | Memory | CD56 | CD57 | FcR | SYK | NKG2C | EAT-2

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Section: Minimal Variation In Total Nk-cell Frequencies Over Timesupporting

confidence: 86%

Dynamic changes in natural killer cell subset frequencies in the absence of cytomegalovirus infection

Gyurova

Schlums

Sucharew

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…In contrast, in another study, B. longum bv. Infantis CCUG 52486, combined with a prebiotic GOS, failed to reduce age-related changes in the NK cell response to seasonal influenza vaccination in elderly compared to young individuals [154]. There were only insignificant effects on B-and T-cell profiles in older subjects compared to those of younger counterparts [155].…”

Section: Synbioticsmentioning

confidence: 89%

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

et al. 2020

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Viral respiratory infections (VRIs) can spread quickly and cause enormous morbidity and mortality worldwide. These events pose serious threats to public health due to time lags in developing vaccines to activate the acquired immune system. The high variability of people’s symptomatic responses to viral infections, as illustrated in the current COVID-19 pandemic, indicates the potential to moderate the severity of morbidity from VRIs. Growing evidence supports roles for probiotic bacteria (PB) and prebiotic dietary fiber (DF) and other plant nutritional bioactives in modulating immune functions. While human studies help to understand the epidemiology and immunopathology of VRIs, the chaotic nature of viral transmissions makes it difficult to undertake mechanistic study where the pre-conditioning of the metabolic and immune system could be beneficial. However, recent experimental studies have significantly enhanced our understanding of how PB and DF, along with plant bioactives, can significantly modulate innate and acquired immunity responses to VRIs. Synbiotic combinations of PB and DF potentiate increased benefits primarily through augmenting the production of short-chain fatty acids (SCFAs) such as butyrate. These and specific plant polyphenolics help to regulate immune responses to both restrain VRIs and temper the neutrophil response that can lead to acute respiratory distress syndrome (ARDS). This review highlights the current understanding of the potential impact of targeted nutritional strategies in setting a balanced immune tone for viral clearance and reinforcing homeostasis. This knowledge may guide the development of public health tactics and the application of functional foods with PB and DF components as a nutritional approach to support countering VRI morbidity.

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“…With the clear immune modulatory effects observed, we hypothesized that B. bronchiseptica carriage had the potential to also affect responses to unrelated immunological stimuli, such as vaccination and infection. Of note, possible influences of microbial carriage on vaccination efficiencies are currently being discussed [ 44 , 45 , 46 , 47 , 60 ]. However, we found that B. bronchiseptica carriers mounted a full humoral response to subcutaneous vaccination with a model antigen.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4+CD25+ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice

Jeron

Boehme

Volckmar

et al. 2018

IJMS

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The respiratory tract is constantly exposed to the environment and displays a favorable niche for colonizing microorganisms. However, the effects of respiratory bacterial carriage on the immune system and its implications for secondary responses remain largely unclear. We have employed respiratory carriage with Bordetella bronchiseptica as the underlying model to comprehensively address effects on subsequent immune responses. Carriage was associated with the stimulation of Bordetella-specific CD4+, CD8+, and CD4+CD25+Foxp3+ T cell responses, and broad transcriptional activation was observed in CD4+CD25+ T cells. Importantly, transfer of leukocytes from carriers to acutely B. bronchiseptica infected mice, resulted in a significantly increased bacterial burden in the recipient’s upper respiratory tract. In contrast, we found that respiratory B. bronchiseptica carriage resulted in a significant benefit for the host in systemic infection with Listeria monocytogenes. Adaptive responses to vaccination and influenza A virus infection, were unaffected by B. bronchiseptica carriage. These data showed that there were significant immune modulatory processes triggered by B. bronchiseptica carriage, that differentially affect subsequent immune responses. Therefore, our results demonstrated the complexity of immune regulation induced by respiratory bacterial carriage, which can be beneficial or detrimental to the host, depending on the pathogen and the considered compartment.

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Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial

Cited by 40 publications

References 58 publications

Dynamic changes in natural killer cell subset frequencies in the absence of cytomegalovirus infection

Dynamic changes in natural killer cell subset frequencies in the absence of cytomegalovirus infection

Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives

Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4+CD25+ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice

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