Age-Related Changes in Trabecular Meshwork Imaging

Gold, Mark; Kansara, Seema; Nagi, Kundandeep S.; Bell, Nicholas P.; Blieden, Lauren S.; Chuang, Alice Z.; Baker, Laura A.; Mankiewicz, Kimberly A.; Feldman, Robert M.

doi:10.1155/2013/295204

Cited by 22 publications

(18 citation statements)

References 19 publications

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“…We speculate that this might be one reason that older individuals are more likely to develop glaucoma. Otherwise, no significant correlation between TM width and age was observed in our study, which is consistent with previous reports [ 19 , 20 ], and because we defined the TM width as the distance between the scleral spur and Schwalbe’s line, these anatomical landmarks as TM boundaries might not vary with increasing age.…”

Section: Discussionsupporting

confidence: 93%

Effect of age on the morphologies of the human Schlemm’s canal and trabecular meshwork measured with swept‑source optical coherence tomography

Chen

Sun

et al. 2018

Eye

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PurposeWe aimed to measure the sizes of Schlemm’s canal (SC) and the trabecular meshwork (TM) in healthy individuals and to evaluate variations with age from childhood to old age by using swept-source optical coherence tomography (OCT).MethodsAnterior chamber angle imaging of the superior, inferior, nasal, and temporal regions of the right and left eyes was performed with swept-source OCT. The diameter and area of SC and TM width and thickness were measured manually from OCT images.ResultsA total of 114 healthy individuals were enrolled and included 48 male subjects and 66 female subjects; their ages ranged from 7 to 83 years. Both the SC diameter and area in the four quadrants decreased significantly with aging (P < 0.001) and were wider in the nasal and temporal quadrants compared with the superior and inferior quadrants. Changes in SC size showed significant positive correlations with axial length (AL) and anterior chamber depth (P < 0.001). There was a significant positive association between age and TM thickness in the nasal and temporal quadrants (P < 0.05). The inferior quadrant TM width was the widest among the quadrants. The superior quadrant TM thickness was the thinnest among the quadrants. Changes in TM thickness in the nasal and temporal quadrants showed a significant negative correlation with AL (P < 0.05). There was no statistically significant correlation in SC and TM parameters with central corneal thickness, intraocular pressure, sex, or right or left eye (P > 0.05).ConclusionsWith aging, the SC diameter and area became smaller, TM thickness increased, and TM width seemed to remain constant. Measurements of the sizes of SC and the TM with swept-source OCT could assist in clinical assessments and treatment planning for glaucoma.

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Section: Discussionsupporting

confidence: 93%

Effect of age on the morphologies of the human Schlemm’s canal and trabecular meshwork measured with swept‑source optical coherence tomography

Chen

Sun

et al. 2018

Eye

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“…Notably, the results of some previously reported studies varied substantially from our results in that they did not show a trend of decrease in TM height with aging 12,17,18 . There may be several reasons for this variation.…”

Section: Discussioncontrasting

confidence: 98%

Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

Choi

Bae

Cho

et al. 2020

Sci Rep

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this study evaluated age-related trabecular meshwork (tM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography (AS-OCT). The distance from the scleral spur to Schwalbe's line in patients with normal open anterior chamber angle was measured using AS-OCT. Results were stratified based on patients' age group-≤40, 41-50, 51-60, 61-70, 71-80, and 81-92 years. Thereafter, the results were compared among the age groups. The mean TM height of the patients was 770.929 ± 76.776 μm. TM height was 853.188 ± 94.117 μm in patients aged ≤40 years; it was 815.309 ± 75.723, 798.115 ± 66.040, 770.942 ± 52.774, 726.716 ± 63.979, and 715.968 ± 63.403 μm in patients aged 41-50, 51-60, 61-70, 71-80, and 81-92 years, respectively. The tM height tended to decrease with increasing age (p < 0.001). TM height was significantly shorter in older patients than in younger ones. Therefore, TM height may change with age and may contribute to increased glaucoma risk and prevalence. Scientific RepoRtS | (2020) 10:7115 | https://doi.Mean TM height categorised by age and sex. The mean TM height of the patients in our study was 770.929 ± 76.776 μm. The mean TM height among men was 764.169 ± 85.300 μm and that among women was 776.938 ± 67.120 μm; there was no significant difference between the two groups (P = 0.1911). The mean TM height of patients aged ≤40 years was 853.188 ± 94.117 μm and those of patients aged 41-50, 51-60, 61-70, 71-80, and 81-92 years were 815.309 ± 75.723 μm, 798.115 ± 66.040 μm, 770.942 ± 52.774 μm, 726.716 ± 63.979 μm, and 715.968 ± 63.403 μm, respectively. TM height tended to decrease with increasing patient age (P < 0.001).These results were validated with post-hoc analysis using the least significant difference (no correction value) and Bonferroni correction (correction value) methods (Table 2 and Fig. 1).Scientific RepoRtS | (2020) 10:7115 | https://doi.

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“…When Schwalbe's line was not visible, the measurement rings that mark 250, 500, and 750 μ m from the SSL were turned on. An angle was graded as “A” if the iris insertion was 500 μ m anterior to the SSL, as the length of the trabecular meshwork is approximately 500 μ m [16, 17]. Both readers examined all study images independently and were masked to the gonioscopy evaluation and FD ASOCT results from the other reader.…”

Section: Participants and Methodsmentioning

confidence: 99%

Agreement between Gonioscopic Examination and Swept Source Fourier Domain Anterior Segment Optical Coherence Tomography Imaging

Rigi

Bell

Lee

et al. 2016

Journal of Ophthalmology

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Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle was classified open or narrow by 2 of 5 glaucoma specialists using gonioscopy and imaged by FD ASOCT in the dark. The superior angle of each FD ASOCT image was graded as open or narrow by 2 masked readers. The same procedures were repeated within 6 months. Kappas for interobserver and intervisit agreements for each instrument and interinstrument agreements were calculated. Results. The mean age was 50.9 (±18.4) years. Interobserver agreements were moderate to good for both gonioscopy (0.57 and 0.69) and FD ASOCT (0.58 and 0.75). Intervisit agreements were moderate to excellent for both gonioscopy (0.53 to 0.86) and FD ASOCT (0.57 and 0.85). Interinstrument agreements were fair to good (0.34 to 0.63), with FD ASOCT classifying more angles as narrow than gonioscopy. Conclusions. Both gonioscopy and FD ASOCT examiners were internally consistent with similar interobserver and intervisit agreements for angle classification. Agreement between instruments was fair to good, with FD ASOCT classifying more angles as narrow than gonioscopy.

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Age-Related Changes in Trabecular Meshwork Imaging

Cited by 22 publications

References 19 publications

Effect of age on the morphologies of the human Schlemm’s canal and trabecular meshwork measured with swept‑source optical coherence tomography

Effect of age on the morphologies of the human Schlemm’s canal and trabecular meshwork measured with swept‑source optical coherence tomography

Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

Agreement between Gonioscopic Examination and Swept Source Fourier Domain Anterior Segment Optical Coherence Tomography Imaging

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