Age-Related Changes of Elements in the Coronary Arteries of Monkeys in Comparison with Those of Humans

Tohno, Yoshiyuki; Tohno, Setsuko; Laleva, Lili; Ongkana, Nutcharin; Minami, Takeshi; Satoh, Hiroyuki; Oishi, Takao; Hayashi, Michihiro; Sinthubua, Apichat; Suwannahoy, Patipath; Mahakkanukrauh, Pasuk

doi:10.1007/s12011-008-8167-y

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…Rhesus monkeys have been considered as a most valuable non-human primate animal model for experimental studies of human physiology and pathogenesis because of their close similarity to humans in many physiological aspects [15]. For the studies of cardiovascular diseases, especially heart disease, Rhesus monkeys are important substitutes for humans.…”

Section: Introductionmentioning

confidence: 99%

Electrocardiographic Characterization of Rhesus Monkey Model of Ischemic Myocardial Infarction Induced by Left Anterior Descending Artery Ligation

et al. 2011

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Myocardial infarction is a leading cause for morbidity and mortality in the modern society. Rhesus monkeys are excellent animal models for experimental and translational studies of cardiovascular diseases in humans. However, some detailed characterizations of cardiovascular disease, such as myocardial infarction, in Rhesus monkeys have not been available. The present study was undertaken to examine the progressive electrocardiographic changes in Rhesus monkeys after left anterior descending (LAD) artery ligation. Male Rhesus monkeys, aged 2-3 years and weighed 4.5-6.0 kg, were subjected to LAD ligation along with sham-operated controls. At 1 week, 1 month, and 6 months after the LAD ligation, ECG recording was performed to detect the progressive changes in ECG. In addition, cardiac magnetic resonance imaging (MRI) and echocardiography were applied to detect the myocardial infarction induced by LAD ligation, and histopathological examination was performed at the end of the experiment to measure the morphological changes. The results showed that QRS and ST-T changed significantly within 1 month after LAD ligation, but recovered to normal at the end of the experiment. The most significant change was a progressive QTc prolongation, which occurred corresponding to the development of myocardial infarction. Both cardiac MRI and echocardiography detected the myocardial infarction that was confirmed by the histopathological examination. This detailed characterization of ECG changes along with the development of myocardial infarction induced by LAD ligation thus demonstrated that the Rhesus monkey model of ischemic myocardial infarction would be an excellent surrogate for human myocardial infarction. This model would also provide an excellent tool for drug discovery and development for cardiac disease.

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Section: Introductionmentioning

confidence: 99%

Electrocardiographic Characterization of Rhesus Monkey Model of Ischemic Myocardial Infarction Induced by Left Anterior Descending Artery Ligation

et al. 2011

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“…As for the tissues of monkeys, the authors investigated age-related changes of elements in the coronary arteries [1], cardiac valves [2], cardiac walls [3], sinoatrial node [4,5], and peroneus longus tendon [6] and found that in all of the four cardiac valves, cardiac walls of the left and right atria and ventricles, and sinoatrial node, the P content decreased significantly in childhood. With regard to the coronary arteries, the P content did not change significantly in the left and right coronary arteries with aging.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Decrease of the Phosphorus Content in the Ligamentum Capitis Femoris of Monkeys

Tohno

Oishi

et al. 2014

Biol Trace Elem Res

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To elucidate compositional changes of the ligament with aging, the authors investigated age-related changes of elements in the ligamentum capitis femoris (LCF) of monkeys with a wide range of ages by direct chemical analysis. Used rhesus and Japanese monkeys consisted of 9 males and 22 females, ranging in age from newborn to 31 years (average age = 10.4 ± 10.9 years). After incineration with nitric acid and perchloric acid, element contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that the P content decreased significantly in the LCFs of monkeys with aging, but other six element contents, Ca, S, Mg, Zn, Fe, and Na, did not change significantly with aging. Assuming that the P content indicated the active cell density and the S content indicated the protein amount, an age-related change of the mass ratio of P/S was examined in the LCFs. The mass ratio of P/S decreased significantly in the LCFs in childhood. Regarding the relationships among elements, significant direct correlations were found among the Ca, P, S, and Mg contents in the LCFs. It was suggested that the active cell density of the connective tissue cells might decrease significantly in the LCF in childhood.

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“…To elucidate compositional changes of the coronary arteries with aging, the authors [1][2][3] investigated age-related changes of elements in the coronary arteries of Japanese, Thais, and monkeys and found that a high accumulation of Ca and P occurred in the left coronary arteries of Japanese and Thais in old age, but did not occur in the left coronary arteries of monkeys in old age. To clarify the manner of accumulation of Ca and P in the human coronary artery, the authors [4] investigated age-related changes of elements in the left coronary artery in comparison with the ascending aorta, aortic valve, and mitral valve and found that the accumulation of Ca and P occurred earlier in the left coronary artery than in all the ascending aorta, aortic valve, and mitral valve.…”

Section: Introductionmentioning

confidence: 99%

Gender Difference in Accumulation of Calcium and Phosphorus in the Left Coronary Arteries of Thais

Tohno

Mahakkanukrauh

et al. 2011

Biol Trace Elem Res

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To examine whether there were gender differences in compositional changes of the coronary artery with aging, the authors investigated the gender difference in age-related changes of elements in the left coronary arteries of Thais by direct chemical analysis. After ordinary dissections by students at Chiang Mai University were finished, the left coronary arteries were resected from Thai subjects. The Thai subjects consisted of 69 men and 34 women. The ages of the male subjects ranged from 25 to 87 years (average age = 62.6 ± 11.4 years) and of the female subjects from 24 to 86 years (average age = 59.4 ± 14.6 years). After incinerating the arteries with nitric acid and perchloric acid, the element content was determined by inductively coupled plasma-atomic emission spectrometry. The Ca and P contents tended to increase in the left coronary arteries of men with age, but the increases were not statistically significant. In the left coronary arteries of women, the Ca and P contents increased significantly and progressively with aging. In addition, the Na content increased significantly in the left coronary arteries of both men and women with aging. The differences in the average contents of Ca and P by age group were observed between the left coronary arteries of men and women. With Student's t test, significant gender differences in the average contents of Ca and P were found in both the 40s and the 70s. The Ca and P contents of the left coronary arteries in the 40s were significantly higher in men than in women. In contrast, the Ca and P contents in the 70s were significantly higher in women than in men. These results indicated that the accumulation of Ca and P in the left coronary arteries of Thais occurred at least 10 years earlier in men than in women, but a higher accumulation of Ca and P in old age occurred in the left coronary arteries of women compared with those of men. The present study revealed that there were significant gender differences in the left coronary arteries with regard to the accumulation of Ca and P with aging. It is reasonable to presume that taking clinical findings into consideration, the gender differences in the left coronary arteries may result from hormonal and/or genetic factors rather than lifestyle factors.

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Age-Related Changes of Elements in the Coronary Arteries of Monkeys in Comparison with Those of Humans

Cited by 17 publications

References 34 publications

Electrocardiographic Characterization of Rhesus Monkey Model of Ischemic Myocardial Infarction Induced by Left Anterior Descending Artery Ligation

Electrocardiographic Characterization of Rhesus Monkey Model of Ischemic Myocardial Infarction Induced by Left Anterior Descending Artery Ligation

Age-Related Decrease of the Phosphorus Content in the Ligamentum Capitis Femoris of Monkeys

Gender Difference in Accumulation of Calcium and Phosphorus in the Left Coronary Arteries of Thais

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