Age Related Changes of GFR in a Population of Kerala

Abstract

BACKGROUND: Glomerular Filtration Rate (GFR) is the best index for assessing kidney function. Ethnicity has a potential influence on GFR. Anatomic and physiological changes of ageing kidney influences GFR. AIMS AND OBJECTIVES: To find age related variations of GFR in a population of Kerala. SUBJECTS AND METHODS: A total of 519 subjects of all ages from the community were screened. Blood pressure, diabetes, mellitus, proteinuria, serum creatinine being checked. Estimated GFR (e GFR) assessed using modification of diet in renal disease [MDRD formula]. RESULTS: The mean e GFR of the population was found to be 61.2±18.2ml/min. and the e GFR of normal subjects excluding diabetes, mellitus, blood pressure and proteinuria was found to be 64.49±20.5ml/min. e-GFR was more for males compared to females, 67.5± 20ml/min and 55.4±14ml/min respectively. e GFR showed a steady decline as the age advanced and it was statistically significant(p < 0.05). CONCLUSION: The age adjusted e GFR of keralite population is much less compared to western standards. A more detailed study in general population is needed.

Estimated Glomerular Filtration Rate (eGFR) in Healthy Kidney Donors

“…The donor profile in terms of age, female predominance in our study is with earlier reports from India. [1,2,4,5,7,9,10] The eGFR by DTPA method (Gates method) ranged from 56-117 ml/min, with mean and standard deviation of 84.56 ml/min and 11.60 respectively. The range and mean eGFR in our study is consistent with other India studies which reported the mean eGFR (Gates method) of 61 to 119.34 ml/min.…”

“…The range and mean eGFR in our study is consistent with other India studies which reported the mean eGFR (Gates method) of 61 to 119.34 ml/min. [1][2][3][4][5][6][7][8][9][10] The GFR in healthy Indian is lower than western population with different studies reporting the mean eGFR from 119 to 130 ml/min. [11,12] The mean eGFR in South Korean was reported as 77.1 ml/min with SD of 16.3, which is similar to mean eGFR from Indian studies.…”

“…[13] There was no significant difference in serum creatinine levels between the age groups; however, the eGFR showed a reducing trend with age, by all 3 methods, consistent with other studies. [1,6] The mean eGFR was higher in males than females by all 3 methods; however, the difference was eGFR was significant only in MDRD method. The insignificant difference in GFR by DTPA between males and females was also demonstrated in an earlier study.…”

“…We have limited data regarding normal eGFR ranges in Indian population. [1][2][3][4][5][6][7][8][9][10][11][12][13] This study was done to determine reference range of eGFR in healthy kidney donors from Kerala.…”

Recent development and future trends in coir fiber‐reinforced green polymer composites: Review and evaluation

“…Mechanical behavior of coir reinforced polyester composite was investigated by Kuriakose et al . They observed the effect of the reinforcement structure and its surface treatment on it.…”