Age-related changes of ocular parameters in Korean subjects

Abstract

Aims:To evaluate the age-related variations of ocular parameters in Korean subjects.Methods:We recruited 314 normal subjects who visited the department of Ophthalmology between January 2007 and October 2007. Refraction, axial length, corneal curvature, white-to-white distance, anterior chamber depth, corneal endothelial cell density, and retinal nerve fiber layer (RNFL) thickness were measured using auto-refractive keratometer, intraocular lens master, noncontact specular microscope, and optical coherence tomography.Result:In correlation analysis, from 19 to 82 years, hyperopic shift showed a strong positive statistical correlation with age (r = 0.553, P < 0.001). Corneal curvatures increased (r = 0.221, P < 0.001), while axial length (r = −0.506, P < 0.001), anterior chamber depth (r = −0.491, P < 0.001) and white-to-white distance (r = −0.205, P < 0.001) decreased with age. Also, corneal endothelial cell density was lower in older patients than in younger patients (r = −0.409, P < 0.001). Compared to younger patients, RNFL thickness was lower in the older patients as well, in all quadrants (superior, r = −0.283, P < 0.001; inferior, r = −0.230, P < 0.001; nasal, r = 0.025, P = 0.676; and temporal, r = −0.393, P < 0.001). According to multiple regression analysis, out of the six parameters measured, only hyperopic shift, anterior chamber depth and corneal endothelial cell density (P < 0.05) had statistically significant correlation with age.Conclusion:Some of the ocular parameters changed with aging. Hyperopic shift, shallowing anterior chamber depth, and reduction of corneal endothelial cell density were only definitely related to age.

Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles

“…Interestingly, Grosvenor et al 22 suggested an emmetropising mechanism in adults causing true decrease in AxL with age while Leighton et al 23 explained that this AxL change may contribute to shallow anterior chamber with age. However, Lee et al 24 in a larger study (n=314) did not find significant AxL reduction in multivariate analysis. All these studies were cross-sectional in nature, and evidence for true change in AxL with age may require carefully conducted longitudinal studies.…”

Reproducibility and age-related changes of ocular parametric measurements in rabbits

“…Many studies have elucidated the age-related changes in human ocular structures, such as the corneal curvature, endothelial cell density, refractive state, ACD and CCT [23-25]. However, there are only a limited number of similar studies that have been performed in animals, especially rabbits.…”

Development of Detailed Korean Adult Eye Model for Lens Dose Calculation

“…1 indicates the measurement locations for the listed nine parameters. The values of these parameters for the Korean eye model were determined by using the data given in scientific literatures [14][15][16][17] which measured the ocular pa- JRPR rameters in Korean adult subjects and Korean reference eye mass given in Choi et al [12]. The priority order of the data used for the determination of the nine parameters is summarized in Table 1.…”

“…Firstly, ACD, RAC, and CD were determined from the data given in Lee et al [14], which measured the ocular parameters from the largest number (i.e., 314) of subjects. Among these three parameters, ACD, which showed apparent correlations to age [14], was exceptionally determined as an age group specific population-weighted mean value by using the recent Korean population census data investigated in January 2020 by Statistics Korea (https://kostat.go.kr/). For this case, the data for the ages between 20 and 50 were exclusively considered for the consistency with the "adult" in ICRP Publication 89 [18].…”

“…For this case, the data for the ages between 20 and 50 were exclusively considered for the consistency with the "adult" in ICRP Publication 89 [18]. Note that it was confirmed by the author that the ACD values given in Lee et al [14] were assumed as the dimension measured from the anterior corneal surface to anterior lens surface, i.e., the sum of CT and ACD. RAC and CD, of which variation with age is negligible [14], were simply determined as the overall mean values.…”