Age-Related Changes of Serum Soluble Interleukin 9 Receptor (sIL-9Rα) in Healthy Subjects

Abstract

Most cytokine receptors including interleukin (IL)-9 have soluble counterparts in body fluids. We planned to investigate the pathophysiological significance of the serum soluble IL-9 receptor (sIL-9R) level. We determined the serum sIL-9Ra chain (sIL-9Ra) levels in 96 healthy Japanese individuals to establish a control value by means of specific human sIL-9Ra ELISA, followed by a preliminary application in a patient with diarrhea positive hemolytic uremic syndrome. Age was negatively correlated with the sIL-9Ra level (Spearman r = -0.241, n = 96, p = 0.0180). The serum sIL-9Ra level showed a progressive decline to the normal adult level by the age of 30. The serum sIL-9Ra level of the patient with HUS was markedly higher than those of the age-matched control from the onset of the disease. Because of the remarkable age-dependent variability of sIL-9Ra in healthy subjects, disease-related changes, as well as therapy-dependent alterations, should be considered with caution. Thus, it is recommended that when the serum sIL-9Ra levels of patients are evaluated, the values should be compared with those of age-matched controls. The established control value will be used to discriminate between normal and the pathological conditions in our future studies.Keywords Soluble interleukin 9 receptor a chain (sIL-9Ra) Á Hemolytic uremic syndrome (HUS) Á ELISA

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An Update on Interleukin-9: From Its Cellular Source and Signal Transduction to Its Role in Immunopathogenesis

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